Zobrazeno 1 - 10
of 18
pro vyhledávání: '"Haydn, Munford"'
Autor:
Louise S. Matheson, Georg Petkau, Beatriz Sáenz-Narciso, Vanessa D’Angeli, Jessica McHugh, Rebecca Newman, Haydn Munford, James West, Krishnendu Chakraborty, Jennie Roberts, Sebastian Łukasiak, Manuel D. Díaz-Muñoz, Sarah E. Bell, Sarah Dimeloe, Martin Turner
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-24 (2022)
Abstract The ZFP36 family of RNA-binding proteins acts post-transcriptionally to repress translation and promote RNA decay. Studies of genes and pathways regulated by the ZFP36 family in CD4+ T cells have focussed largely on cytokines, but their impa
Externí odkaz:
https://doaj.org/article/502be5987af14790b105142b3363eb12
Autor:
Alexander C. Dowell, Haydn Munford, Anshita Goel, Naheema S. Gordon, Nicholas D. James, K. K. Cheng, Maurice P. Zeegers, Douglas G. Ward, Richard T. Bryan
Publikováno v:
Frontiers in Oncology, Vol 11 (2021)
The use of immune checkpoint blockade, in particular PD-1 and PD-L1 inhibitors, is now commonplace in many clinical settings including the treatment of muscle-invasive bladder cancer (MIBC). Notwithstanding, little information exists regarding the ex
Externí odkaz:
https://doaj.org/article/a6407fd65c5047b08c56e5b712248dad
Autor:
Kate E.R. Hollinshead, Haydn Munford, Katherine L. Eales, Chiara Bardella, Chunjie Li, Cristina Escribano-Gonzalez, Alpesh Thakker, Yannic Nonnenmacher, Katarina Kluckova, Mark Jeeves, Robert Murren, Federica Cuozzo, Dan Ye, Giulio Laurenti, Wei Zhu, Karsten Hiller, David J. Hodson, Wei Hua, Ian P. Tomlinson, Christian Ludwig, Ying Mao, Daniel A. Tennant
Publikováno v:
Cell Reports, Vol 22, Iss 12, Pp 3107-3114 (2018)
Summary: Since the discovery of mutations in isocitrate dehydrogenase 1 (IDH1) in gliomas and other tumors, significant efforts have been made to gain a deeper understanding of the consequences of this oncogenic mutation. One aspect of the neomorphic
Externí odkaz:
https://doaj.org/article/26706adfa2534c22a56f1079550fabca
Publikováno v:
Journal of Pediatric Hematology/Oncology. 45:e82-e86
Cytomegalovirus (CMV) infection is a serious complication of pediatric hematopoietic stem cell transplant (HSCT). To date, antiviral therapy has been the mainstay of prophylaxis, with conflicting results regarding the benefits of CMV-specific immunog
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d5c2d2332131481a8c9e4919c7620a00
https://doi.org/10.1097/mph.0000000000002553
https://doi.org/10.1097/mph.0000000000002553
Autor:
Haydn Munford, Sarah Dimeloe
Publikováno v:
Frontiers in Molecular Biosciences, Vol 6 (2019)
T lymphocytes are a critical component of the adaptive immune system, with key roles in the immune response to infection and cancer. Their activity is fundamentally underpinned by dynamic, regulated changes in their metabolism. This ensures adequate
Externí odkaz:
https://doaj.org/article/f3846636261e47f4876a882103c22b1d
Autor:
Bishop Gudgeon, Hannah Giles, Emma L Bishop, Taylor Fulton-Ward, Cristina Escribano-Gonzalez, Haydn Munford, Anna James-Bott, Kane Foster, Farheen Karim, Dedunu Jayawardana, Ansar Mahmood, Adam Cribbs, Daniel A. Tennant, Supratik Basu, Guy Pratt, Sarah Dimeloe
Background Multiple Myeloma (MM) is a plasma cell malignancy that develops in the bone marrow. Function of T lymphocytes is impaired in patients with MM and the bone marrow microenvironment is described as hostile for T cell activity. Precise suppres
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8d4117b2efc677d07e9764a4e9e19364
https://doi.org/10.21203/rs.3.rs-2500541/v1
https://doi.org/10.21203/rs.3.rs-2500541/v1
Autor:
Thomas Brendan Smith, Kamlesh Patel, Haydn Munford, Andrew Peet, Daniel A. Tennant, Mark Jeeves, Christian Ludwig
Publikováno v:
Wellcome Open Research, Vol 3 (2018)
Tracing the fate of stable isotopically-enriched nutrients is a sophisticated method of describing and quantifying the activity of metabolic pathways. Nuclear Magnetic Resonance (NMR) spectroscopy offers high resolution data in terms of resolving met
Externí odkaz:
https://doaj.org/article/454994c018864c81a014a27e3875af60
Autor:
Thomas Brendan Smith, Kamlesh Patel, Haydn Munford, Andrew Peet, Daniel A. Tennant, Mark Jeeves, Christian Ludwig
Publikováno v:
Wellcome Open Research, Vol 3 (2018)
Tracing the fate of stable isotopically-enriched nutrients is a sophisticated method of describing and quantifying the activity of metabolic pathways. Nuclear Magnetic Resonance (NMR) offers high resolution data, yet is under-utilised due to length o
Externí odkaz:
https://doaj.org/article/f7772f58ab35446bb8f62653581dd6c8
Autor:
Nancy Gudgeon, Haydn Munford, Emma L. Bishop, James Hill, Taylor Fulton-Ward, David Bending, Jennie Roberts, Daniel A. Tennant, Sarah Dimeloe
Publikováno v:
Cell Reports. 40:111193
Succinate dehydrogenase (SDH) loss-of-function mutations drive succinate accumulation in tumor microenvironments, for example in the neuroendocrine tumors pheochromocytoma (PC) and paraganglioma (PG). Control of innate immune cell activity by succina
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dfbcb1520420d9ecf74f2c7e4ffa4815
https://doi.org/10.1016/j.celrep.2022.111193
https://doi.org/10.1016/j.celrep.2022.111193
Autor:
Nancy Gudgeon, Haydn Munford, Emma Bishop, James Hill, Taylor Fulton-Ward, David Bending, Jennie Roberts, Daniel Tennant, Sarah Dimeloe
Publikováno v:
SSRN Electronic Journal.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1f5591e6c1ac2192e4d9b99e2df4c6fc
https://doi.org/10.2139/ssrn.3992090
https://doi.org/10.2139/ssrn.3992090