Zobrazeno 1 - 10
of 15
pro vyhledávání: '"Hayden Weng-Siong Tan"'
Publikováno v:
Liver Research, Vol 7, Iss 1, Pp 56-70 (2023)
Autophagy is a highly conserved process in which cytosolic contents are degraded by the lysosome, which plays an important role in energy and nutrient balance, and protein or organelle quality control. The liver is the most important organ for metabo
Externí odkaz:
https://doaj.org/article/cf7c6647f777429c8375a148196780e9
Autor:
Hayden Weng Siong Tan, Guang Lu, Han Dong, Yik-Lam Cho, Auginia Natalia, Liming Wang, Charlene Chan, Dennis Kappei, Reshma Taneja, Shuo-Chien Ling, Huilin Shao, Shih-Yin Tsai, Wen-Xing Ding, Han-Ming Shen
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-17 (2022)
The mechanisms underlying mitochondrial quality control are not fully understood. Here the authors identify a switch from degradative to secretory autophagy in the absence of the mATG8-conjugation system, termed Autophagic Secretion of Mitochondria.
Externí odkaz:
https://doaj.org/article/5faa98dd54e74eb38a71aec60636557b
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-10 (2017)
mTORC1 is a critical kinase that regulates cell growth and proliferation. Here the authors show that glutamine metabolism is sufficient to restore mTORC1 activity during prolonged amino acid starvation in an autophagy-dependent manner.
Externí odkaz:
https://doaj.org/article/baa64e48583c47e993cde6f66f813394
Publikováno v:
Mitochondrial Communications. 1:13-15
Autor:
Hayden Weng Siong Tan, Guang Lu, Han Dong, Yik-Lam Cho, Auginia Natalia, Liming Wang, Charlene Chan, Dennis Kappei, Reshma Taneja, Shuo-Chien Ling, Huilin Shao, Shih-Yin Tsai, Wen-Xing Ding, Han-Ming Shen
Publikováno v:
Nature communications. 13(1)
PINK1-Parkin mediated mitophagy, a selective form of autophagy, represents one of the most important mechanisms in mitochondrial quality control (MQC) via the clearance of damaged mitochondria. Although it is well known that the conjugation of mammal
Autor:
Chenxi Ouyang, Han-Ming Shen, Juan Yi, Yihua Wu, Liming Wang, Ruey-Hwa Chen, Nai-Di Yang, Guang Lu, Andrea Gubas, Man Wu, Shuo Deng, Tianru Wang, Ya-Ting Wang, Yi Ren, Hayden Weng Siong Tan, Sharon A. Tooze, Yin Shi, Dajing Xia
Macroautophagy/autophagy is a cellular process in which cytosolic contents are degraded by lysosome in response to various stress conditions. Apart from its role in the maintenance of cellular homeostasis, autophagy also involves in regulation of cel
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::38809a6e5616253acc6fc21281a827cd
Autor:
Rizwan Wahab, Yik-Lam Cho, Weifeng He, Han-Ming Shen, Javed Ahmad, Quaiser Saquib, Yi Ren, Boon-Huat Bay, Hayden Weng Siong Tan
Publikováno v:
Free radical biologymedicine. 153
Nickel oxide nanoparticles (NiO-NPs) are an important group of nanoparticles with increasing applications in many aspects of industry. At present, there is evidence demonstrating the cytotoxic characteristics of NiO-NPs, while the involvement of auto
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-10 (2017)
Nature Communications
Nature Communications
Activation of autophagy and elevation of glutamine synthesis represent key adaptations to maintain amino acid balance during starvation. In this study, we investigate the role of autophagy and glutamine on the regulation of mTORC1, a critical kinase
Lysosomes influence dynamic cellular processes such as nutrient sensing and transcriptional regulation. To explore novel transcriptional pathways regulated by lysosomes, we performed microarray analysis followed by qPCR validation in a mouse hepatocy
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a30537accebad3dc43be7ee42423cbe9
Autor:
Yih-Cherng Liou, Yin Shi, Hanry Yu, Jianbin Zhang, Han-Ming Shen, Shuo Deng, Liming Wang, Yik-Lam Cho, Guang Lu, Pornteera Pawijit, Boon-Huat Bay, Kah-Leong Lim, Hayden Weng-Siong Tan, Jingzi Zhang, Yajun Wu, Yihua Wu, Jigang Wang, Yancheng Tang, Celestial T. Yap, Yan Tong, Lei Fang, Hui-Ying Chan, Grace Gui-Yin Lim, Mallilankaraman Karthik, Jung Eun Park, Ritu Chawla, Siu Kwan Sze, Chunxin Wang
Publikováno v:
Cell Research
Mitophagy is an important type of selective autophagy for specific elimination of damaged mitochondria. PTEN-induced putative kinase protein 1 (PINK1)-catalyzed phosphorylation of ubiquitin (Ub) plays a critical role in the onset of PINK1–Parkin-me