Zobrazeno 1 - 10
of 18
pro vyhledávání: '"Hayden R. Schmidt"'
Autor:
Yu Lan, Ping Bai, Zude Chen, Ramesh Neelamegam, Michael S. Placzek, Hao Wang, Stephanie A. Fiedler, Jing Yang, Gengyang Yuan, Xiying Qu, Hayden R. Schmidt, Jinchun Song, Marc D. Normandin, Chongzhao Ran, Changning Wang
Publikováno v:
Acta Pharmaceutica Sinica B, Vol 9, Iss 6, Pp 1204-1215 (2019)
The sigma-1 receptor (σ1R) is a unique intracellular protein. σ1R plays a major role in various pathological conditions in the central nervous system (CNS), implicated in several neuropsychiatric disorders. Imaging of σ1R in the brain using positr
Externí odkaz:
https://doaj.org/article/6f8047a7f7314da6b2b69e01ff50ae50
Autor:
Hayden R. Schmidt, Richard Benton
Publikováno v:
Open Biology, Vol 10, Iss 10 (2020)
Insects thrive in diverse ecological niches in large part because of their highly sophisticated olfactory systems. Over the last two decades, a major focus in the study of insect olfaction has been on the role of olfactory receptors in mediating neur
Externí odkaz:
https://doaj.org/article/7247468141ba47438b2502eb01b6fffa
Autor:
Meredith A. Skiba, Jacob R. Anderson, Hayden R. Schmidt, Daniel A. Greenfield, Andrew C. Kruse, Michael Mandler, Piotr Sliz
Publikováno v:
ACS Medicinal Chemistry Letters. 11:1555-1561
The σ1 receptor is a transmembrane protein implicated in several pathophysiological conditions, including neurodegenerative disease (J. Pharmacol. Sci.2015127 (1), 1729), drug addiction (Behav. Pharmacol.201627 (2-3 Spec Issue), 10015), cancer (Hand
Autor:
Jing Yang, Ramesh Neelamegam, Jinchun Song, Gengyang Yuan, Ping Bai, Chongzhao Ran, Marc D. Normandin, Changning Wang, Michael S. Placzek, Zude Chen, Hayden R. Schmidt, Stephanie A. Fiedler, Hao Wang, Yu Lan, Xiying Qu
Publikováno v:
Acta Pharmaceutica Sinica B, Vol 9, Iss 6, Pp 1204-1215 (2019)
Acta Pharmaceutica Sinica. B
Acta Pharmaceutica Sinica. B
The sigma-1 receptor (σ1R) is a unique intracellular protein. σ1R plays a major role in various pathological conditions in the central nervous system (CNS), implicated in several neuropsychiatric disorders. Imaging of σ1R in the brain using positr
Olfactory receptor repertoires exhibit remarkable functional diversity, but how these proteins have evolved is poorly understood. Through analysis of extant and ancestrally-reconstructed drosophilid olfactory receptors from the Ionotropic Receptor (I
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ea3fa1426c72a46698ba1767a35f82b1
https://doi.org/10.1101/2021.04.23.440888
https://doi.org/10.1101/2021.04.23.440888
Publikováno v:
eLife
eLife, Vol 10 (2021)
eLife, vol. 10, pp. e69732
eLife, Vol 10 (2021)
eLife, vol. 10, pp. e69732
Olfactory receptor repertoires exhibit remarkable functional diversity, but how these proteins have evolved is poorly understood. Through analysis of extant and ancestrally reconstructed drosophilid olfactory receptors from the Ionotropic receptor (I
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e369cdcd33ace09839aaf885cc11f8e3
Autor:
Daniel A, Greenfield, Hayden R, Schmidt, Meredith A, Skiba, Michael D, Mandler, Jacob R, Anderson, Piotr, Sliz, Andrew C, Kruse
Publikováno v:
ACS Med Chem Lett
[Image: see text] The σ(1) receptor is a transmembrane protein implicated in several pathophysiological conditions, including neurodegenerative disease (J. Pharmacol. Sci.2015127 (1), 172925704014), drug addiction (Behav. Pharmacol.201627 (2–3 Spe
Publikováno v:
European Journal of Medicinal Chemistry. 151:557-567
Substituted norbenzomorphans are known to display high affinity and selectivity for the two sigma receptor (σR) subtypes. In order to study the effects of simplifying the structures of these compounds, a scaffold hopping strategy was used to design
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 27:2912-2919
Fenpropimorph (1) is considered a "super high-affinity" σ1 receptor ligand (Ki=0.005nM for guinea pig σ1 receptors). Here, we examine the binding of 1 and several of its deconstructed analogs at human σ1 (hσ1) receptors. We monitored their subtyp