Zobrazeno 1 - 7
of 7
pro vyhledávání: '"Hayden L Bell"'
Autor:
Hayden L. Bell, Helen J. Blair, Mankaran Singh, Anthony V. Moorman, Olaf Heidenreich, Frederik W. van Delft, John Lunec, Julie A. E. Irving
Publikováno v:
Cancer Cell International, Vol 23, Iss 1, Pp 1-14 (2023)
Abstract Background Outcomes for patients with relapsed acute lymphoblastic leukemia (ALL) are poor and there is a need for novel therapies to improve outcomes. Targeted inhibition of WEE1 with small-molecule inhibitor adavosertib (AZD1775) has emerg
Externí odkaz:
https://doaj.org/article/9deed2b8e0db4595931334af42559dac
Autor:
Friedrich Stölzel, Sarah E. Fordham, Devi Nandana, Wei-Yu Lin, Helen Blair, Claire Elstob, Hayden L. Bell, Brigitte Mohr, Leo Ruhnke, Desiree Kunadt, Claudia Dill, Daniel Allsop, Rachel Piddock, Emmanouela-Niki Soura, Catherine Park, Mohd Fadly, Thahira Rahman, Abrar Alharbi, Manja Wobus, Heidi Altmann, Christoph Röllig, Lisa Wagenführ, Gail L. Jones, Tobias Menne, Graham H. Jackson, Helen J. Marr, Jude Fitzgibbon, Kenan Onel, Manja Meggendorfer, Amber Robinson, Zuzanna Bziuk, Emily Bowes, Olaf Heidenreich, Torsten Haferlach, Sara Villar, Beñat Ariceta, Rosa Ayala Diaz, Steven J. Altschuler, Lani F. Wu, Felipe Prosper, Pau Montesinos, Joaquin Martinez-Lopez, Martin Bornhäuser, James M. Allan
Publikováno v:
JCI Insight, Vol 8, Iss 2 (2023)
Precision medicine can significantly improve outcomes for patients with cancer, but implementation requires comprehensive characterization of tumor cells to identify therapeutically exploitable vulnerabilities. Here, we describe somatic biallelic TET
Externí odkaz:
https://doaj.org/article/099cf4b757194708b07592874d0436b2
Autor:
Jill E. Hunter, Amy E. Campbell, Nicola L. Hannaway, Scott Kerridge, Saimir Luli, Jacqueline A. Butterworth, Helene Sellier, Reshmi Mukherjee, Nikita Dhillon, Praveen D. Sudhindar, Ruchi Shukla, Philip J. Brownridge, Hayden L. Bell, Jonathan Coxhead, Leigh Taylor, Peter Leary, Megan S.R. Hasoon, Ian Collins, Michelle D. Garrett, Claire E. Eyers, Neil D. Perkins
Publikováno v:
Biochemical Journal. 479:2063-2086
Previously, we discovered that deletion of c-Rel in the Eµ-Myc mouse model of lymphoma results in earlier onset of disease, a finding that contrasted with the expected function of this NF-κB subunit in B-cell malignancies. Here we report that Eµ-M
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::df12386d5171f9c615727f2b67ddab70
https://doi.org/10.1042/bcj20220102
https://doi.org/10.1042/bcj20220102
Autor:
Friedrich, Stölzel, Sarah E, Fordham, Devi, Nandana, Wei-Yu, Lin, Helen J, Blair, Claire J, Elstob, Hayden L, Bell, Brigitte, Mohr, Leo, Ruhnke, Desiree, Kunadt, Claudia, Dill, Daniel A, Allsop, Rachel E, Piddock, Emmanouela-Niki, Soura, Catherine Vida, Park, Mohd, Fadly, Thahira, Rahman, Abrar A, Alharbi, Manja, Wobus, Heidi, Altmann, Christoph, Röllig, Lisa, Wagenführ, Gail L, Jones, Tobias, Menne, Graham H, Jackson, Helen J, Marr, Jude, Fitzgibbon, Kenan, Onel, Manja, Meggendorfer, Amber, Robinson, Zuzanna, Bziuk, Emily, Bowes, Olaf, Heidenreich, Torsten, Haferlach, Sara, Villar, Beñat, Ariceta, Rosa, Ayala Diaz, Steven J, Altschuler, Lani, Wu, Felipe, Prosper, Pau, Montesinos, Joaquin, Martinez-Lopez, Martin, Bornhäuser, James M, Allan
Publikováno v:
JCI insight.
Precision medicine can significantly improve outcomes for cancer patients, but implementation requires comprehensive characterization of tumor cells to identify therapeutically exploitable vulnerabilities. Here we describe somatic biallelic TET2 muta
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::3118e95282b68b0294fbe97bd7863b76
https://pubmed.ncbi.nlm.nih.gov/36480300
https://pubmed.ncbi.nlm.nih.gov/36480300
Publikováno v:
Klinische Pädiatrie.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::fb2cff946a1924eb02783e58551a27ca
https://doi.org/10.1055/s-0039-1687172
https://doi.org/10.1055/s-0039-1687172
Autor:
John Lunec, Anthony V. Moorman, Julie Irving, Mankaran Singh, Hayden L Bell, Helen J. Blair, Frederik W. van Delft
Publikováno v:
Blood. 136:38-38
Outcomes for adult patients with acute lymphoblastic leukemia (ALL) are dismal and have not kept pace with their pediatric counterparts, with five-year survival rates of less than 45%. TP53 mutations are infrequent in ALL, but activity of the oncopro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0ab85b2e9f0ef28c33f0c568705e7132
https://doi.org/10.1182/blood-2020-139536
https://doi.org/10.1182/blood-2020-139536
Autor:
Edward T. Parkin, Hayden L Bell
Publikováno v:
International Journal of Cancer Therapy and Oncology, Vol 4, Iss 2 (2016)
The poor efficacy of many cancer chemotherapeutics, which are often non-selective and highly toxic, is attributable to the remarkable heterogeneity and adaptability of cancer cells. The Warburg effect describes the up regulation of glycolysis as the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9fe020e7f50d73c4b25aae776f906bcc
http://ijcto.org/index.php/IJCTO/article/view/509
http://ijcto.org/index.php/IJCTO/article/view/509