Zobrazeno 1 - 8
of 8
pro vyhledávání: '"Hayden A Homer"'
Autor:
Robert Gilchrist, Wing-Hong Jonathan Ho, Maria B Marinova, Dave R Listijono, Michael J Bertoldo, Dulama Richani, Kim Lynn-Jee, Amelia Brown, Angelique H Riepsamen, Safaa Cabot, Sonia Bustamante, Ling Zhong, Kaisa Selesniemi, Derek Wong, Dale M Goss, Catherine Li, Toshiyuki Araki, David J Livingston, Nigel Turner, David A Sinclair, Kirsty A Walters, Hayden A Homer, Lindsay E Wu
Publikováno v:
Fertility & Reproduction, Vol 05, Iss 04, Pp 518-518 (2023)
Background and Aims: Chemotherapy induced ovarian failure and infertility is an important concern in female cancer patients of reproductive age or younger, and non-invasive, pharmacological approaches to prevent chemotherapy induced infertility are u
Externí odkaz:
https://doaj.org/article/34e09bb2cf2c4adf92b3339f6ca9ecaf
Autor:
Chenxi Zhou, Hayden A. Homer
Publikováno v:
Cell Reports, Vol 39, Iss 5, Pp 110789- (2022)
Summary: Inactivation of cyclin-dependent kinase 1 (Cdk1), controlled by cyclin B1 proteolysis, orders events during mitotic exit. Here, we used a FRET biosensor to study Cdk1 activity while simultaneously monitoring anaphase II and pronuclear (PN) f
Externí odkaz:
https://doaj.org/article/5d79608cf18544518495266376ac9b5c
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-14 (2020)
Meiotic cell division in oocytes is asymmetric and requires microtubule spindle migration after anaphase-onset. Here, the authors show that Nampt, an enzyme of the Nicotinamide adenine dinucleotide (NAD) biosynthetic pathway, contributes to post-anap
Externí odkaz:
https://doaj.org/article/225ffd678086472ca6ac67cee6e2a022
Autor:
Hayden A. Homer
Publikováno v:
Frontiers in Genetics, Vol 12 (2021)
Early decline in ovarian function known as premature ovarian aging (POA) occurs in around 10% of women and is characterized by a markedly reduced ovarian reserve. Premature ovarian insufficiency (POI) affects ~1% of women and refers to the severe end
Externí odkaz:
https://doaj.org/article/25053d4082cb42f58fc455cd3ae2142f
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-15 (2018)
Female meiotic divisions are asymmetric with the formation of large oocytes and small polar bodies, thought to result from cortical spindle placement before anaphase. The authors find that Cdk1 inactivation triggers F-actin dependent post-anaphase sp
Externí odkaz:
https://doaj.org/article/db71a765213d4b4e883beac5d9417968
Autor:
Michael J. Bertoldo, Dave R. Listijono, Wing-Hong Jonathan Ho, Angelique H. Riepsamen, Dale M. Goss, Dulama Richani, Xing L. Jin, Saabah Mahbub, Jared M. Campbell, Abbas Habibalahi, Wei-Guo Nicholas Loh, Neil A. Youngson, Jayanthi Maniam, Ashley S.A. Wong, Kaisa Selesniemi, Sonia Bustamante, Catherine Li, Yiqing Zhao, Maria B. Marinova, Lynn-Jee Kim, Laurin Lau, Rachael M. Wu, A. Stefanie Mikolaizak, Toshiyuki Araki, David G. Le Couteur, Nigel Turner, Margaret J. Morris, Kirsty A. Walters, Ewa Goldys, Christopher O’Neill, Robert B. Gilchrist, David A. Sinclair, Hayden A. Homer, Lindsay E. Wu
Publikováno v:
Cell Reports, Vol 30, Iss 6, Pp 1670-1681.e7 (2020)
Summary: Reproductive aging in female mammals is an irreversible process associated with declining oocyte quality, which is the rate-limiting factor to fertility. Here, we show that this loss of oocyte quality with age accompanies declining levels of
Externí odkaz:
https://doaj.org/article/a90efaf77b4241cf832c48855e659c9a
Autor:
Pia Astbury, Goutham N. Subramanian, Jessica Greaney, Chris Roling, Jacqui Irving, Hayden A. Homer
Publikováno v:
Medical Sciences, Vol 8, Iss 1, p 4 (2020)
Here we investigate whether the presence of germinal vesicle-stage oocytes (GV− oocytes) reflects poor oocyte developmental competence (or quality). This was a prospective, non-randomised, cohort pilot-study involving 60 patients undergoing in vitr
Externí odkaz:
https://doaj.org/article/03e0ebd57741489ab39dfb8ad669fe76
Autor:
Yunan Ye, Hayden Anthony Homer
Publikováno v:
Cell Reports, Vol 43, Iss 3, Pp 113917- (2024)
Summary: Embryonic genome activation (EGA) marks the transition from dependence on maternal transcripts to an embryonic transcriptional program. The precise temporal regulation of gene expression, specifically the silencing of the Dux/murine endogeno
Externí odkaz:
https://doaj.org/article/442cbcb5bcf74205a8415af99dedb22b