Zobrazeno 1 - 9
of 9
pro vyhledávání: '"Hayde Sanchez"'
Publikováno v:
PLoS ONE, Vol 9, Iss 9, p e107359 (2014)
The intracellular mechanisms underlying memory reconsolidation critically involve cAMP signaling. These events were originally attributed to PKA activation by cAMP, but the identification of Exchange Protein Activated by cAMP (Epac), as a distinct me
Externí odkaz:
https://doaj.org/article/57e8a695aaca4598a84aebf2203d48f3
Publikováno v:
Neuropsychopharmacology. 42:587-597
Sustained abstinence from cocaine use is frequently compromised by exposure to environmental stimuli that have previously been strongly associated with drug taking. Such cues trigger memories of the effects of the drug, leading to craving and potenti
Autor:
Peter Olausson, Hayde Sanchez, Jane R. Taylor, James A. Bibb, Wendy J. Lynch, Eric J. Nestler
Publikováno v:
Proceedings of the National Academy of Sciences. 104:4147-4152
Neuronal adaptations in striatal dopamine signaling have been implicated in enhanced responses to addictive drugs. Cyclin-dependent kinase 5 (Cdk5) regulates striatal dopamine signaling and is a downstream target gene of the transcription factor ΔFo
Publikováno v:
Psychopharmacology. 177:391-399
Previously, we demonstrated that neonatal isolation increases acquisition of cocaine self-administration in adult male rats.Now we examine whether neonatal isolation enhances maintenance and cocaine-induced reinstatement of extinguished self-administ
Publikováno v:
PLoS ONE, Vol 9, Iss 9, p e107359 (2014)
PLoS ONE
PLoS ONE
The intracellular mechanisms underlying memory reconsolidation critically involve cAMP signaling. These events were originally attributed to PKA activation by cAMP, but the identification of Exchange Protein Activated by cAMP (Epac), as a distinct me
Publikováno v:
The Journal of neuroscience : the official journal of the Society for Neuroscience. 30(31)
Extinction therapy has been proposed as a method to reduce the motivational impact of drug-associated cues to prevent relapse. Cue extinction therapy, however, takes place in a novel context (e.g., treatment facility), and is unlikely to be effective
Publikováno v:
The Journal of neuroscience : the official journal of the Society for Neuroscience. 30(12)
Drug addiction is a chronic disorder associated with recurrent craving and relapse often precipitated by the presence of drug-associated stimuli. Pharmacological and behavioral treatments that disrupt drug-associated stimulus memories could be benefi
Publikováno v:
Psychoneuroendocrinology. 30(8)
We demonstrated that neonatal isolation (ISO) increases acquisition of cocaine self-administration and alters psychostimulant-induced ventral striatal dopamine and serotonin levels in female rats. Both dopamine and serotonin modulate the behavioral e
Publikováno v:
Behavioural brain research. 151(1-2)
We showed previously that neonatal isolation (ISO) enhances acquisition of cocaine self-administration in adult male rats without altering acquisition of food responding. Female rats show poorer performance in learning tasks and are differentially af