Indole induces anxiety-like behaviour in mice mediated by brainstem locus coeruleus activation

Autor: Hayatte-Dounia Mir, Qingning Yang, Elise Maximin, Quentin Montardy, Shuqin Ji, Qi Cheng, Xiaochun Shan, Liping Wang, Laurent Naudon, Sylvie Rabot, Lei Li

Publikováno v: Neurobiology of Disease, Vol 200, Iss , Pp 106606- (2024)

The gut microbiota produces metabolites that enrich the host metabolome and play a part in host physiology, including brain functions. Yet the biological mediators of this gut-brain signal transduction remain largely unknown. In this study, the possi

Externí odkaz: https://doaj.org/article/1036f3eed220496e8935965f1d584fa5

The gut microbiota metabolite indole increases emotional responses and adrenal medulla activity in chronically stressed male mice

Autor: Sylvie Rabot, Alexandre Milman, Veronique Douard, Nathalie Castanon, Catherine Philippe, Agnès Aubert, Hayatte-Dounia Mir, Laurent Naudon, Sylvie Vancassel, Magali Monnoye, Nathalie C. Guérineau

Publikováno v: Psychoneuroendocrinology
Psychoneuroendocrinology, Elsevier, 2020, 119, pp.1-10. ⟨10.1016/j.psyneuen.2020.104750⟩
Psychoneuroendocrinology, Elsevier, 2020, 119, pp.104750. ⟨10.1016/j.psyneuen.2020.104750⟩
Psychoneuroendocrinology, 2020, 119, pp.104750. ⟨10.1016/j.psyneuen.2020.104750⟩

International audience; Background and aims: The gut microbiota produces metabolites that are an integral part of the metabolome and, as such, of the host physiology. Changes in gut microbiota metabolism could therefore contribute to pathophysiologic

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::529aca7018c7d1fec558dc6145050a63
https://hal.archives-ouvertes.fr/hal-02879931/document