Výsledky vyhledávání - "Hayato Ujihira"

Pharmacokinetic Study of the Structural Components of Adenosine Diphosphate-Encapsulated Liposomes Coated with Fibrinogenγ-Chain Dodecapeptide as a Synthetic Platelet Substitute

Autor: Yosuke Okamura, Hayato Ujihira, Yasuo Ikeda, Hiroshi Watanabe, Masaki Otagiri, Toru Maruyama, Kazuaki Taguchi, Mami Doi, Shigeru Ogaki, Makoto Handa, Atsushi Fujiyama, Shinji Takeoka

Publikováno v: Drug Metabolism and Disposition. 41:1584-1591

Fibrinogen γ-chain (dodecapeptide HHLGGAKQAGDV, H12)-coated, ADP-encapsulated liposomes [H12-(ADP)-liposomes] were developed as a synthetic platelet alternative that specifically accumulates at bleeding sites as the result of interactions with activ

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d3476e71755204cb41df7a46b9e76b35
https://doi.org/10.1124/dmd.112.050005

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Hepatically-metabolized and -excreted artificial oxygen carrier, hemoglobin vesicles, can be safely used under conditions of hepatic impairment

Autor: Kazuaki Taguchi, Hiromi Sakai, Hayato Ujihira, Daisuke Kadowaki, Hiroshi Watanabe, Mayumi Miyasato, Eishun Tsuchida, Masaki Otagiri, Toru Maruyama, Koichi Kobayashi, Hirohisa Horinouchi

Publikováno v: Toxicology and applied pharmacology. 248(3)

The hemoglobin vesicle (HbV) is an artificial oxygen carrier in which a concentrated Hb solution is encapsulated in lipid vesicles. Our previous studies demonstrated that HbV is metabolized by the mononuclear phagocyte system, and the lipid component

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e38758457fd86263c726fbb9e714c37f
https://pubmed.ncbi.nlm.nih.gov/20709091

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