Výsledky vyhledávání - "Hayato Nishiyama"

Novel Keap1-Nrf2 Protein-Protein Interaction Inhibitor UBE-1099 Ameliorates Progressive Phenotype in Alport Syndrome Mouse Model

Autor: Shota Kaseda, Yuya Sannomiya, Jun Horizono, Jun Kuwazuru, Mary Ann Suico, Sayaka Ogi, Ryoko Sasaki, Hidetoshi Sunamoto, Hirohiko Fukiya, Hayato Nishiyama, Misato Kamura, Saki Niinou, Yuimi Koyama, Futoshi Nara, Tsuyoshi Shuto, Kazuhiro Onuma, Hirofumi Kai

Publikováno v: Kidney360

BACKGROUND: Bardoxolone methyl activates nuclear factor erythroid 2–related factor 2 (Nrf2) via covalent binding and irreversible inhibition of Kelch-like ECH-associated protein 1 (Keap1), the negative regulator of Nrf2. Ongoing clinical trials of

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2e3d502c89ec9099fd5c10558fc0c7bb
https://pubmed.ncbi.nlm.nih.gov/35721612

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Efficacy of Keap1-Nrf2 protein-protein interaction inhibitor for glomerulosclerosis in mouse model of chronic kidney disease

Autor: Shota Kaseda, Yuya Sannomiya, Jun Horizono, Jun Kuwazuru, Mary Ann Suico, Sayaka Ogi, Ryoko Sasaki, Hidetoshi Sunamoto, Hirohiko Fukiya, Hayato Nishiyama, Misato Kamura, Futoshi Nara, Tsuyoshi Shuto, Kazuhiro Onuma, Hirofumi Kai

Publikováno v: Proceedings for Annual Meeting of The Japanese Pharmacological Society. 95:1-YIA

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::3f122231a086e048a53c0f321abe7c2e
https://doi.org/10.1254/jpssuppl.95.0_1-yia-22

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Akademický článek

Decarbonylative Radical Coupling of a-Aminoacyl Tellurides: Single-Step Preparation of γ-Amino and α,β-Diamino Acids and Rapid Synthesis of Gabapentin and Manzacidin A.

Autor: Masanori Nagatomo¹, Hayato Nishiyama¹, Haruka Fujino¹, Masayuki Inoue¹ inoue@mol.f.u-tokyo.ac.jp

Publikováno v: Angewandte Chemie. Jan2015, Vol. 127 Issue 5, p1557-1561. 5p.

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ChemInform Abstract: Decarbonylative Radical Coupling of α-Aminoacyl Tellurides: Single-Step Preparation of γ-Amino and α,β-Diamino Acids and Rapid Synthesis of Gabapentin and Manzacidin A

Autor: Haruka Fujino, Masanori Nagatomo, Hayato Nishiyama, Masayuki Inoue

Publikováno v: ChemInform. 46

α-Aminoacyl tellurides (III) and (IX) generate α-amino carbon radicals via decarbonylation.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::b061be7ad649a88aea50b65b8320e146
https://doi.org/10.1002/chin.201524223

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Decarbonylative radical coupling of α-aminoacyl tellurides: single-step preparation of γ-amino and α,β-diamino acids and rapid synthesis of gabapentin and manzacidin A

Autor: Hayato Nishiyama, Masayuki Inoue, Masanori Nagatomo, Haruka Fujino

Publikováno v: Angewandte Chemie (International ed. in English). 54(5)

A new radical-based coupling method has been developed for the single-step generation of various γ-amino acids and α,β-diamino acids from α-aminoacyl tellurides. Upon activation by Et3 B and O2 at ambient temperature, α-aminoacyl tellurides were

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4150c0f83b0292db5879d7d382bfdf91
https://pubmed.ncbi.nlm.nih.gov/25504989

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