Zobrazeno 1 - 5
of 5
pro vyhledávání: '"Hayat S. Abdulkerim"'
Autor:
Georgia Giannoukos, Dawn M. Ciulla, Eugenio Marco, Hayat S. Abdulkerim, Luis A. Barrera, Anne Bothmer, Vidya Dhanapal, Sebastian W. Gloskowski, Hariharan Jayaram, Morgan L. Maeder, Maxwell N. Skor, Tongyao Wang, Vic E. Myer, Christopher J. Wilson
Publikováno v:
BMC Genomics, Vol 19, Iss 1, Pp 1-10 (2018)
Abstract Background Understanding the diversity of repair outcomes after introducing a genomic cut is essential for realizing the therapeutic potential of genomic editing technologies. Targeted PCR amplification combined with Next Generation Sequenci
Externí odkaz:
https://doaj.org/article/85150464620e4b6d8346790e56c87003
Autor:
Anne Bothmer, Tanushree Phadke, Luis A. Barrera, Carrie M Margulies, Christina S. Lee, Frank Buquicchio, Sean Moss, Hayat S. Abdulkerim, William Selleck, Hariharan Jayaram, Vic E. Myer, Cecilia Cotta-Ramusino
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-12 (2017)
CRISPR-Cas9 has rapidly become a common molecular biology tool for modifying genomes and has been modified to generate single-strand nicks as well as double-strand breaks. Here the authors explore the DNA repair pathways activated by the different va
Externí odkaz:
https://doaj.org/article/0e7ab32becea4c83bb655f0d5113f731
Autor:
Cecilia Cotta-Ramusino, Hayat S Abdulkerim, Eugenio Marco, Frank Buquicchio, Cecilia Fernández, John A. Zuris, Lucas Cohen, Ramya Viswanathan, Kenneth W Gareau, Anne Bothmer, Vic E. Myer
Publikováno v:
The CRISPR Journal. 3:177-187
Multiplexed genome editing with DNA endonucleases has broad application, including for cellular therapies, but chromosomal translocations, natural byproducts of inducing simultaneous genomic breaks, have not been explored in detail. Here we apply var
Autor:
Luis A. Barrera, Hayat S Abdulkerim, Frank Buquicchio, Hariharan Jayaram, Carrie M Margulies, Tanushree Phadke, Christina S. Lee, Anne Bothmer, William Selleck, Sean Moss, Vic E. Myer, Cecilia Cotta-Ramusino
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-12 (2017)
Nature Communications
Nature Communications
The CRISPR–Cas9 system provides a versatile toolkit for genome engineering that can introduce various DNA lesions at specific genomic locations. However, a better understanding of the nature of these lesions and the repair pathways engaged is criti
Autor:
Hari Jayaram, Hayat S Abdulkerim, Luis A. Barrera, Tanushree Phadke, Christina Lee, S. Moss, Anne Bothmer, Cecilia Cotta-Ramusino
Publikováno v:
Molecular Therapy. 24:S230
Sickle Cell Anemia is an inherited recessive disorder caused by a single point mutation in the human beta globin (HBB) gene resulting in an abnormal type of hemoglobin. Here we report targeting the HBB locus using CRISPR/Cas9 technology for correctio