Zobrazeno 1 - 10
of 18
pro vyhledávání: '"Hayarpi Torosyan"'
Autor:
Hayarpi Torosyan, Michael D. Paul, Antoine Forget, Megan Lo, Devan Diwanji, Krzysztof Pawłowski, Nevan J. Krogan, Natalia Jura, Kliment A. Verba
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-17 (2023)
Abstract PEAK pseudokinases are molecular scaffolds which dimerize to regulate cell migration, morphology, and proliferation, as well as cancer progression. The mechanistic role dimerization plays in PEAK scaffolding remains unclear, as there are no
Externí odkaz:
https://doaj.org/article/85045834d2964cfea366be106c88604c
Autor:
Megan Lo, Amnon Sharir, Michael D. Paul, Hayarpi Torosyan, Christopher Agnew, Amy Li, Cynthia Neben, Pauline Marangoni, Libin Xu, David R. Raleigh, Natalia Jura, Ophir D. Klein
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-13 (2022)
Although lipids are known to affect Hedgehog (Hh) signalling, the underlying mechanisms remain unclear. Here, the authors show that Canopy4 regulates membrane sterol lipid levels, with knockout mouse embryos exhibiting digit number changes and other
Externí odkaz:
https://doaj.org/article/b8f457610c994aaaac3b168715601a9d
Autor:
Celine Lacroix, Inbar Fish, Hayarpi Torosyan, Pranavan Parathaman, John J Irwin, Brian K Shoichet, Stephane Angers
Publikováno v:
PLoS ONE, Vol 11, Iss 8, p e0160365 (2016)
The seven transmembrane protein Smoothened is required for Hedgehog signaling during embryonic development and adult tissue homeostasis. Inappropriate activation of the Hedgehog signalling pathway leads to cancers such as basal cell carcinoma and med
Externí odkaz:
https://doaj.org/article/45204d954e4d462081efc52f42c0bd10
Autor:
Hayarpi Torosyan, Michael D. Paul, Antoine Forget, Megan Lo, Devan Diwanji, Krzysztof Pawłowski, Nevan J. Krogan, Natalia Jura, Kliment A. Verba
Publikováno v:
Nature communications, vol 14, iss 1
The three members of the PEAK family of pseudokinases (PEAK1, PEAK2, and PEAK3) are molecular scaffolds that have recently emerged as important regulatory nodes in signaling pathways that control cell migration, morphology, and proliferation, and the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cf7988d86847647a1f08671cca6cabce
https://doi.org/10.1101/2022.09.01.506268
https://doi.org/10.1101/2022.09.01.506268
Autor:
Hua Li, Patrick Kwok Shing Ng, Gordon B. Mills, Janice Cho, Danielle L. Swaney, Daniel Johnson, Gabi Tarcic, Mi-Ok Kim, Natalia Jura, Yan Zeng, Bhumsuk Keam, Michelle J. Lee, Hyunseok Kang, Zohar Barbash, Julie E. Bauman, Hayarpi Torosyan, Nevan J. Krogan, Nathan K. VanLandingham, Hye Ryun Kim, Nan Jin, Jennifer R. Grandis
Publikováno v:
The Journal of clinical investigation, vol 131, iss 22
J Clin Invest
J Clin Invest
Alpelisib selectively inhibits the p110α catalytic subunit of PI3Kα and is approved for treatment of breast cancers harboring canonical PIK3CA mutations. In head and neck squamous cell carcinoma (HNSCC), 63% of PIK3CA mutations occur at canonical h
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b8ff55fc1287790733f423737cb6d1b5
https://escholarship.org/uc/item/2mg9x9k4
https://escholarship.org/uc/item/2mg9x9k4
Autor:
Zun Zar Chi Naing, Maru Jaime-Garza, Taia S. Wu, Laurel S Estes, Martin Kampmann, Eric D. Chow, Taylor B. Cavazos, Miriam A. Goldman, Yessica K. Gomez, William F. DeGrado, Stephanie A. Wankowicz, Matthew C. Johnson, Christa Caggiano, Christina A. Stephens, Bryan Faust, Daniel Barrero, Lakshmi E. Miller-Vedam, Elizabeth E. McCarthy, Kyle E. Lopez, Sy Redding, Jenna Pellegrino, Elissa A Fink, Wren Saylor, Alison M Maxwell, Hayarpi Torosyan, Jared Lumpe, Robert W. Newberry, George C. Hartoularos, Daniel M. C. Schwarz, Calla Martyn, Laura M. Gunsalus, Jack Strickland, Maureen Pittman, Taylor Arhar, Andrew F. Kung, Daniel R. Wong, Garrett Wong, Nishith R. Reddy, Matthew G. Jones, Aji Palar, Erik J. Navarro, Nick Hoppe, M. Grace Gordon, Douglas R. Wassarman, Jean Costello, Adam Catching
Publikováno v:
ACS Chem Biol
ACS chemical biology, vol 15, iss 8
ACS chemical biology, vol 15, iss 8
Protein conformations are shaped by cellular environments, but how environmental changes alter the conformational landscapes of specific proteins in vivo remains largely uncharacterized, in part due to the challenge of probing protein structures in l
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8292e5bf8e0f1174d79b4faba3fc334b
Autor:
Brian K. Shoichet, Molly S. Shoichet, Da Duan, David A. Agard, Christopher K. McLaughlin, Jennifer Logie, Daniel Elnatan, Hayarpi Torosyan
Publikováno v:
ACS chemical biology, vol 12, iss 1
Colloidal aggregates of small molecules are the most common artifact in early drug discovery, sequestering and inhibiting target proteins without specificity. Understanding their structure and mechanism has been crucial to developing tools to control
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5783ea3178e89a4decc48b690dbd636a
https://doi.org/10.1021/acschembio.6b00791
https://doi.org/10.1021/acschembio.6b00791
Autor:
S. Nassir Ghaemi, Guiqing Liang, Duncan Armstrong, Hong Jin, Bryan L. Roth, Joshua Pottel, Brian K. Shoichet, Xi Ping Huang, Alexander Fekete, Laszlo Urban, Kathleen M. Giacomini, Ellen L. Berg, John J. Irwin, Steven Whitebread, Ling Zou, Hayarpi Torosyan, Katalin V. Lukacs, Barun Bhhatarai, Samuel T. Slocum, Dallas Bednarczyk
Publikováno v:
Science (New York, N.Y.), vol 369, iss 6502
Science
Science
Excipients, considered “inactive ingredients,” are a major component of formulated drugs and play key roles in their pharmacokinetics. Despite their pervasiveness, whether they are active on any targets has not been systematically explored. We co
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d09b20fb65c9cd3b8fabfaad38953262
https://pubmed.ncbi.nlm.nih.gov/32728229
https://pubmed.ncbi.nlm.nih.gov/32728229
Autor:
Molly S. Shoichet, Hayarpi Torosyan, Eric N. Donders, P. Lak, Ahil N. Ganesh, Brian K. Shoichet
Publikováno v:
ACS chemical biology, vol 14, iss 7
Chemotherapeutics that self-assemble into colloids have limited efficacy above their critical aggregation concentration due to their inability to penetrate intact plasma membranes. Even when colloid uptake is promoted, issues with colloid escape from
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e0a3e9e881df89ed3f76f2ede5bbcdc8
https://pubmed.ncbi.nlm.nih.gov/31243955
https://pubmed.ncbi.nlm.nih.gov/31243955
Autor:
Brian K. Shoichet, Molly S. Shoichet, Christopher K. McLaughlin, Da Duan, Ahil N. Ganesh, Hayarpi Torosyan
Publikováno v:
ACS chemical biology, vol 11, iss 4
Small molecule aggregates are considered nuisance compounds in drug discovery, but their unusual properties as colloids could be exploited to form stable vehicles to preserve protein activity. We investigated the co-aggregation of seven molecules cho
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d19c300cb203b99fabb5887e815091a3
https://doi.org/10.1021/acschembio.5b00806
https://doi.org/10.1021/acschembio.5b00806