Výsledky vyhledávání - "Hayarpi Torosyan"

Akademický článek

Structural insights into regulation of the PEAK3 pseudokinase scaffold by 14-3-3

Autor: Hayarpi Torosyan, Michael D. Paul, Antoine Forget, Megan Lo, Devan Diwanji, Krzysztof Pawłowski, Nevan J. Krogan, Natalia Jura, Kliment A. Verba

Publikováno v: Nature Communications, Vol 14, Iss 1, Pp 1-17 (2023)

Abstract PEAK pseudokinases are molecular scaffolds which dimerize to regulate cell migration, morphology, and proliferation, as well as cancer progression. The mechanistic role dimerization plays in PEAK scaffolding remains unclear, as there are no

Externí odkaz: https://doaj.org/article/85045834d2964cfea366be106c88604c

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Akademický článek

CNPY4 inhibits the Hedgehog pathway by modulating membrane sterol lipids

Autor: Megan Lo, Amnon Sharir, Michael D. Paul, Hayarpi Torosyan, Christopher Agnew, Amy Li, Cynthia Neben, Pauline Marangoni, Libin Xu, David R. Raleigh, Natalia Jura, Ophir D. Klein

Publikováno v: Nature Communications, Vol 13, Iss 1, Pp 1-13 (2022)

Although lipids are known to affect Hedgehog (Hh) signalling, the underlying mechanisms remain unclear. Here, the authors show that Canopy4 regulates membrane sterol lipid levels, with knockout mouse embryos exhibiting digit number changes and other

Externí odkaz: https://doaj.org/article/b8f457610c994aaaac3b168715601a9d

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Akademický článek

Identification of Novel Smoothened Ligands Using Structure-Based Docking.

Autor: Celine Lacroix, Inbar Fish, Hayarpi Torosyan, Pranavan Parathaman, John J Irwin, Brian K Shoichet, Stephane Angers

Publikováno v: PLoS ONE, Vol 11, Iss 8, p e0160365 (2016)

The seven transmembrane protein Smoothened is required for Hedgehog signaling during embryonic development and adult tissue homeostasis. Inappropriate activation of the Hedgehog signalling pathway leads to cancers such as basal cell carcinoma and med

Externí odkaz: https://doaj.org/article/45204d954e4d462081efc52f42c0bd10

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Therapeutic implications of activating noncanonical PIK3CA mutations in head and neck squamous cell carcinoma

Publikováno v: The Journal of clinical investigation, vol 131, iss 22
J Clin Invest

Alpelisib selectively inhibits the p110α catalytic subunit of PI3Kα and is approved for treatment of breast cancers harboring canonical PIK3CA mutations. In head and neck squamous cell carcinoma (HNSCC), 63% of PIK3CA mutations occur at canonical h

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b8ff55fc1287790733f423737cb6d1b5
https://escholarship.org/uc/item/2mg9x9k4

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Robust Sequence Determinants of α-Synuclein Toxicity in Yeast Implicate Membrane Binding

Publikováno v: ACS Chem Biol
ACS chemical biology, vol 15, iss 8

Protein conformations are shaped by cellular environments, but how environmental changes alter the conformational landscapes of specific proteins in vivo remains largely uncharacterized, in part due to the challenge of probing protein structures in l

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8292e5bf8e0f1174d79b4faba3fc334b

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Internal Structure and Preferential Protein Binding of Colloidal Aggregates

Autor: Brian K. Shoichet, Molly S. Shoichet, Da Duan, David A. Agard, Christopher K. McLaughlin, Jennifer Logie, Daniel Elnatan, Hayarpi Torosyan

Publikováno v: ACS chemical biology, vol 12, iss 1

Colloidal aggregates of small molecules are the most common artifact in early drug discovery, sequestering and inhibiting target proteins without specificity. Understanding their structure and mechanism has been crucial to developing tools to control

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5783ea3178e89a4decc48b690dbd636a
https://doi.org/10.1021/acschembio.6b00791

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The activities of drug inactive ingredients on biological targets

Publikováno v: Science (New York, N.Y.), vol 369, iss 6502
Science

Excipients, considered “inactive ingredients,” are a major component of formulated drugs and play key roles in their pharmacokinetics. Despite their pervasiveness, whether they are active on any targets has not been systematically explored. We co

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d09b20fb65c9cd3b8fabfaad38953262
https://pubmed.ncbi.nlm.nih.gov/32728229

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Triggered Release Enhances the Cytotoxicity of Stable Colloidal Drug Aggregates

Autor: Molly S. Shoichet, Hayarpi Torosyan, Eric N. Donders, P. Lak, Ahil N. Ganesh, Brian K. Shoichet

Publikováno v: ACS chemical biology, vol 14, iss 7

Chemotherapeutics that self-assemble into colloids have limited efficacy above their critical aggregation concentration due to their inability to penetrate intact plasma membranes. Even when colloid uptake is promoted, issues with colloid escape from

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e0a3e9e881df89ed3f76f2ede5bbcdc8
https://pubmed.ncbi.nlm.nih.gov/31243955

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Stable Colloidal Drug Aggregates Catch and Release Active Enzymes

Autor: Brian K. Shoichet, Molly S. Shoichet, Christopher K. McLaughlin, Da Duan, Ahil N. Ganesh, Hayarpi Torosyan

Publikováno v: ACS chemical biology, vol 11, iss 4

Small molecule aggregates are considered nuisance compounds in drug discovery, but their unusual properties as colloids could be exploited to form stable vehicles to preserve protein activity. We investigated the co-aggregation of seven molecules cho

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d19c300cb203b99fabb5887e815091a3
https://doi.org/10.1021/acschembio.5b00806

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