Zobrazeno 1 - 10
of 33
pro vyhledávání: '"Hayam M. A. Ashour"'
Autor:
Nesreen S. Haiba, Adnan A. Bekhit, Doaa Ragab, Sherine N. Khattab, Kholod A. Elhasany, Mohammad A. Abdulkader, Hayam M. A. Ashour, Maged W. Helmy, Amira Zaky, Ahmed O. Elzoghby, Mohamed Teleb
Publikováno v:
European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V. 155
Breast cancer is not only one of the most prevalent types of cancer, but also it is a prime cause of death in women aged between 20 and 59. Although chemotherapy is the most common therapy approach, multiple side effects can result from lack of speci
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cb7b9b143224f7ccb2e2bc16e185e8f8
https://pubmed.ncbi.nlm.nih.gov/32818610
https://pubmed.ncbi.nlm.nih.gov/32818610
Publikováno v:
Letters in Drug Design & Discovery. 16:200-212
Background: In attempts to discover new antiangiogenic entities, a novel series of thioethers derived from 6-thioxo-6,7-dihydro-1H-pyrazolo[3,4-d]pyrimidine-4(5H)ones was considered and designed. Methods: Virtual screening was carried out through doc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ac70ae45625f7a202f3e3addb873f508
https://doi.org/10.2174/1570180815666180518112321
https://doi.org/10.2174/1570180815666180518112321
Autor:
Ibrahim M. Labouta, Mounir A. Khalil, Gina N. Tageldin, Salwa M. Fahmy, Rasha A. Nassra, Hayam M. A. Ashour
Publikováno v:
Bioorganic Chemistry. 80:164-173
Two new series of pyrazolo[3,4-d]pyrimidine bearing thiazolidinone moiety were designed and synthesized. The newly synthesized compounds were evaluated for their in vitro (COX-1 and COX-2) inhibitory assay. Compounds that showed promising COX-2 selec
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1b69d56dfa7381c50873443d7887516f
https://doi.org/10.1016/j.bioorg.2018.06.013
https://doi.org/10.1016/j.bioorg.2018.06.013
Publikováno v:
Bioorganic Chemistry. 76:154-165
The receptor tyrosine kinase c-Met is an attractive target for therapeutic treatment of cancers nowadays. Herein we describe the design and synthesis of a novel series of 1,2,4-triazine derivatives based on our lead NCI 748494/1, possessing different
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::496242691dd78ee3b5390c79fecdf067
https://doi.org/10.1016/j.bioorg.2017.11.006
https://doi.org/10.1016/j.bioorg.2017.11.006
Publikováno v:
Bioorganic Chemistry. 73:154-169
In silico target fishing approach using PharmMapper server identified c-Met kinase as the selective target for our previously synthesized compound NCI 748494/1. This approach was validated by in vitro kinase assay which showed that NCI 748494/1 posse
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::564fadc8b1c0880532339a04300e12a7
https://doi.org/10.1016/j.bioorg.2017.06.009
https://doi.org/10.1016/j.bioorg.2017.06.009
Publikováno v:
Monatshefte für Chemie - Chemical Monthly. 147:539-552
New tetrahydroquinoline derivatives were synthesized, characterized, and evaluated for their in vitro and in vivo acetylcholinesterase inhibitory activity as well as hepatotoxicity using tacrine as a reference standard. The obtained results revealed
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::20bdb59c458f147413f379688a2362c1
https://doi.org/10.1007/s00706-015-1641-2
https://doi.org/10.1007/s00706-015-1641-2
Autor:
Hayam M. A. Ashour, Tamer M. Ibrahim, Rasha A. Nassra, Mounir A. Khalil, Ibrahim M. Labouta, Salwa M. Fahmy, Gina N. Tageldin
Publikováno v:
Bioorganic chemistry. 90
New pyrazolo[3,4-d]pyrimidinone and pyrazolo[4,3-e][1,2,4]triazolo[4,3-a]pyrimidinone derivatives were synthesized. They have been evaluated for their anti-inflammatory activity using in vitro (COX-1/COX-2) inhibitory assay. Moreover, compounds with
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6073263e2aaa839f1bd05452dec8174c
https://pubmed.ncbi.nlm.nih.gov/31229797
https://pubmed.ncbi.nlm.nih.gov/31229797
Publikováno v:
Medicinal Chemistry.
The incentive of the present work has been primarily directed towards the design and synthesis of some novel pyrido[1,2-a]benzimidazoles with specific functionalities believed to have alkylation ability. This combination of pharmacological agents may
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5c453a9f862fb5eee71b77c0ed1f7241
https://doi.org/10.4172/2161-0444.1000498
https://doi.org/10.4172/2161-0444.1000498
Publikováno v:
Monatshefte für Chemie - Chemical Monthly. 147:605-618
New compounds comprising the pyrazolyl benzenesulfonamide scaffold linked to polysubstituted pyrazoles and thiazolidinones were synthesized and evaluated for their anti-inflammatory and analgesic activities. The results revealed that most of the comp
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::08bda665f8740c5acee29134152e4163
https://doi.org/10.1007/s00706-015-1549-x
https://doi.org/10.1007/s00706-015-1549-x
Publikováno v:
Journal of Enzyme Inhibition and Medicinal Chemistry. 30:786-795
In this study, novel thiosemicarbazides and 1,3,4-oxadiazoles were synthesized and evaluated for their anticancer effects on human MCF-7 breast cancer cell lines. Among the synthesized derivatives studied, compound 2-(3-(4-chlorophenyl)-3-hydroxybuta
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5f545900ba6eef2e432a49414d98dc54
https://doi.org/10.3109/14756366.2014.971781
https://doi.org/10.3109/14756366.2014.971781