Discovery and Optimization of Selective Nav1.8 Modulator Series That Demonstrate Efficacy in Preclinical Models of Pain.

Autor: Bagal SK; Worldwide Medicinal Chemistry, Pfizer Neusentis , The Portway Building, Granta Park, Great Abington, Cambridge CB21 6GS, U.K., Bungay PJ; Neusentis U.K., Pfizer Global R&D , The Portway Building, Granta Park, Cambridge CB21 6GS, U.K., Denton SM; Worldwide Medicinal Chemistry, Pfizer Global R&D , Sandwich CT13 9NJ, U.K., Gibson KR; Worldwide Medicinal Chemistry, Pfizer Global R&D , Sandwich CT13 9NJ, U.K., Glossop MS; Worldwide Medicinal Chemistry, Pfizer Global R&D , Sandwich CT13 9NJ, U.K., Hay TL; Worldwide Medicinal Chemistry, Pfizer Global R&D , Sandwich CT13 9NJ, U.K., Kemp MI; Worldwide Medicinal Chemistry, Pfizer Global R&D , Sandwich CT13 9NJ, U.K., Lane CA; Worldwide Medicinal Chemistry, Pfizer Global R&D , Sandwich CT13 9NJ, U.K., Lewis ML; Worldwide Medicinal Chemistry, Pfizer Global R&D , Sandwich CT13 9NJ, U.K., Maw GN; Worldwide Medicinal Chemistry, Pfizer Global R&D , Sandwich CT13 9NJ, U.K., Million WA; Worldwide Medicinal Chemistry, Pfizer Global R&D , Sandwich CT13 9NJ, U.K., Payne CE; Neusentis U.K., Pfizer Global R&D , The Portway Building, Granta Park, Cambridge CB21 6GS, U.K., Poinsard C; Worldwide Medicinal Chemistry, Pfizer Global R&D , Sandwich CT13 9NJ, U.K., Rawson DJ; Worldwide Medicinal Chemistry, Pfizer Global R&D , Sandwich CT13 9NJ, U.K., Stammen BL; Worldwide Medicinal Chemistry, Pfizer Global R&D , Sandwich CT13 9NJ, U.K., Stevens EB; Neusentis U.K., Pfizer Global R&D , The Portway Building, Granta Park, Cambridge CB21 6GS, U.K., Thompson LR; Worldwide Medicinal Chemistry, Pfizer Global R&D , Sandwich CT13 9NJ, U.K.

Publikováno v: ACS medicinal chemistry letters [ACS Med Chem Lett] 2015 Apr 29; Vol. 6 (6), pp. 650-4. Date of Electronic Publication: 2015 Apr 29 (Print Publication: 2015).