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Accelerated waning of the humoral response to COVID-19 vaccines in obesity.

Autor: van der Klaauw AA; University of Cambridge Metabolic Research Laboratories and NIHR Cambridge Biomedical Research Centre, Wellcome-Medical Research Council (MRC) Institute of Metabolic Science, University of Cambridge, Cambridge, UK., Horner EC; MRC Toxicology Unit, University of Cambridge, Cambridge, UK., Pereyra-Gerber P; Cambridge Institute of Therapeutic Immunology and Infectious Disease, University of Cambridge, Cambridge, UK.; Department of Medicine, University of Cambridge, Cambridge, UK., Agrawal U; Nuffield Department of Primary Care Health Sciences, University of Oxford, Oxford, UK., Foster WS; Babraham Institute, Babraham Research Campus, Cambridge, UK., Spencer S; MRC Toxicology Unit, University of Cambridge, Cambridge, UK., Vergese B; University of Cambridge Metabolic Research Laboratories and NIHR Cambridge Biomedical Research Centre, Wellcome-Medical Research Council (MRC) Institute of Metabolic Science, University of Cambridge, Cambridge, UK.; NIHR Cambridge Clinical Research Facility, Cambridge University Hospitals NHS Foundation Trust, Cambridge, UK., Smith M; University of Cambridge Metabolic Research Laboratories and NIHR Cambridge Biomedical Research Centre, Wellcome-Medical Research Council (MRC) Institute of Metabolic Science, University of Cambridge, Cambridge, UK., Henning E; University of Cambridge Metabolic Research Laboratories and NIHR Cambridge Biomedical Research Centre, Wellcome-Medical Research Council (MRC) Institute of Metabolic Science, University of Cambridge, Cambridge, UK., Ramsay ID; Cambridge Institute of Therapeutic Immunology and Infectious Disease, University of Cambridge, Cambridge, UK.; Department of Medicine, University of Cambridge, Cambridge, UK.; Department of Infectious Diseases, Cambridge University Hospitals NHS Foundation Trust, Cambridge, UK., Smith JA; Cambridge Institute of Therapeutic Immunology and Infectious Disease, University of Cambridge, Cambridge, UK.; Department of Medicine, University of Cambridge, Cambridge, UK., Guillaume SM; Babraham Institute, Babraham Research Campus, Cambridge, UK., Sharpe HJ; Babraham Institute, Babraham Research Campus, Cambridge, UK., Hay IM; Babraham Institute, Babraham Research Campus, Cambridge, UK.; Cambridge Institute for Medical Research, University of Cambridge, Cambridge, UK., Thompson S; Babraham Institute, Babraham Research Campus, Cambridge, UK., Innocentin S; Babraham Institute, Babraham Research Campus, Cambridge, UK., Booth LH; MRC Toxicology Unit, University of Cambridge, Cambridge, UK., Robertson C; Department of Mathematics and Statistics, University of Strathclyde, Glasgow, UK., McCowan C; Nuffield Department of Primary Care Health Sciences, University of Oxford, Oxford, UK., Kerr S; Usher Institute, University of Edinburgh, Edinburgh, UK., Mulroney TE; MRC Toxicology Unit, University of Cambridge, Cambridge, UK., O'Reilly MJ; MRC Toxicology Unit, University of Cambridge, Cambridge, UK., Gurugama TP; MRC Toxicology Unit, University of Cambridge, Cambridge, UK., Gurugama LP; MRC Toxicology Unit, University of Cambridge, Cambridge, UK., Rust MA; MRC Toxicology Unit, University of Cambridge, Cambridge, UK., Ferreira A; MRC Toxicology Unit, University of Cambridge, Cambridge, UK., Ebrahimi S; Immunology, Cambridge University Hospitals NHS Foundation Trust, Cambridge, UK.; Clinical Biochemistry, Cambridge University Hospitals NHS Foundation Trust, Cambridge, UK., Ceron-Gutierrez L; Immunology, Cambridge University Hospitals NHS Foundation Trust, Cambridge, UK.; Clinical Biochemistry, Cambridge University Hospitals NHS Foundation Trust, Cambridge, UK., Scotucci J; University of Cambridge Metabolic Research Laboratories and NIHR Cambridge Biomedical Research Centre, Wellcome-Medical Research Council (MRC) Institute of Metabolic Science, University of Cambridge, Cambridge, UK., Kronsteiner B; Peter Medawar Building for Pathogen Research, Nuffield Department of Clinical Medicine, University of Oxford, Oxford, UK., Dunachie SJ; Peter Medawar Building for Pathogen Research, Nuffield Department of Clinical Medicine, University of Oxford, Oxford, UK.; NDM Centre for Global Health Research, Nuffield Department of Medicine, University of Oxford, Oxford, UK.; NIHR Oxford Biomedical Research Centre, Oxford University Hospitals NHS Foundation Trust, Oxford, UK.; Translational Gastroenterology Unit, University of Oxford, Oxford, UK.; Mahidol-Oxford Tropical Medicine Research Unit, Bangkok, Thailand., Klenerman P; Peter Medawar Building for Pathogen Research, Nuffield Department of Clinical Medicine, University of Oxford, Oxford, UK.; NDM Centre for Global Health Research, Nuffield Department of Medicine, University of Oxford, Oxford, UK.; NIHR Oxford Biomedical Research Centre, Oxford University Hospitals NHS Foundation Trust, Oxford, UK.; Translational Gastroenterology Unit, University of Oxford, Oxford, UK., Park AJ; Clinical Biochemistry, Cambridge University Hospitals NHS Foundation Trust, Cambridge, UK., Rubino F; Department of Diabetes, King's College London and King's College Hospital NHS Foundation Trust, London, UK., Lamikanra AA; NHS Blood and Transplant, Oxford, UK.; Radcliffe Department of Medicine, University of Oxford, Oxford, UK., Stark H; NIHR BioResource, Cambridge University Hospitals NHS Foundation Trust, Cambridge, UK., Kingston N; NIHR BioResource, Cambridge University Hospitals NHS Foundation Trust, Cambridge, UK., Estcourt L; NHS Blood and Transplant, Oxford, UK.; Radcliffe Department of Medicine, University of Oxford, Oxford, UK., Harvala H; NHS Blood and Transplant, London, UK., Roberts DJ; NHS Blood and Transplant, Oxford, UK.; Radcliffe Department of Medicine, University of Oxford, Oxford, UK., Doffinger R; Immunology, Cambridge University Hospitals NHS Foundation Trust, Cambridge, UK.; Clinical Biochemistry, Cambridge University Hospitals NHS Foundation Trust, Cambridge, UK., Linterman MA; Babraham Institute, Babraham Research Campus, Cambridge, UK., Matheson NJ; Cambridge Institute of Therapeutic Immunology and Infectious Disease, University of Cambridge, Cambridge, UK.; Department of Medicine, University of Cambridge, Cambridge, UK.; Department of Infectious Diseases, Cambridge University Hospitals NHS Foundation Trust, Cambridge, UK.; NHS Blood and Transplant, Cambridge, UK., Sheikh A; Usher Institute, University of Edinburgh, Edinburgh, UK. aziz.sheikh@ed.ac.uk., Farooqi IS; University of Cambridge Metabolic Research Laboratories and NIHR Cambridge Biomedical Research Centre, Wellcome-Medical Research Council (MRC) Institute of Metabolic Science, University of Cambridge, Cambridge, UK. isf20@cam.ac.uk., Thaventhiran JED; MRC Toxicology Unit, University of Cambridge, Cambridge, UK. jedt2@cam.ac.uk.

Publikováno v: Nature medicine [Nat Med] 2023 May; Vol. 29 (5), pp. 1146-1154. Date of Electronic Publication: 2023 May 11.

Tfh cells and the germinal center are required for memory B cell formation & humoral immunity after ChAdOx1 nCoV-19 vaccination.

Autor: Foster WS; Lymphocyte Signalling and Development, Babraham Institute, Babraham Research Campus, Cambridge CB22 3AT, UK., Lee JL; Lymphocyte Signalling and Development, Babraham Institute, Babraham Research Campus, Cambridge CB22 3AT, UK., Thakur N; The Pirbright Institute, Ash Road, Pirbright GU24 0NF, UK; Oxford Vaccine Group, Department of Paediatrics, Medical Sciences Division, University of Oxford and Chinese Academy of Medical Science (CAMS) Oxford Institute (COI), Oxford OX3 7BN, UK., Newman J; The Pirbright Institute, Ash Road, Pirbright GU24 0NF, UK., Spencer AJ; The Jenner Institute, University of Oxford, Old Road Campus Research Building, Roosevelt Drive, Oxford OX3 7DQ, UK., Davies S; Oxford Vaccine Group, Department of Paediatrics, Medical Sciences Division, University of Oxford and Chinese Academy of Medical Science (CAMS) Oxford Institute (COI), Oxford OX3 7BN, UK., Woods D; The Jenner Institute, University of Oxford, Old Road Campus Research Building, Roosevelt Drive, Oxford OX3 7DQ, UK., Godfrey L; The Jenner Institute, University of Oxford, Old Road Campus Research Building, Roosevelt Drive, Oxford OX3 7DQ, UK., Hay IM; Signalling Programme, Babraham Institute, Babraham Research Campus, Cambridge CB22 3AT, UK; Cambridge Institute for Medical Research, Hills Road, Cambridge CB2 0XY, UK., Innocentin S; Lymphocyte Signalling and Development, Babraham Institute, Babraham Research Campus, Cambridge CB22 3AT, UK., Yam-Puc JC; MRC Toxicology Unit, Gleeson Building, Tennis Court Road, Cambridge CB2 1QR, UK., Horner EC; MRC Toxicology Unit, Gleeson Building, Tennis Court Road, Cambridge CB2 1QR, UK., Sharpe HJ; Signalling Programme, Babraham Institute, Babraham Research Campus, Cambridge CB22 3AT, UK., Thaventhiran JE; MRC Toxicology Unit, Gleeson Building, Tennis Court Road, Cambridge CB2 1QR, UK., Bailey D; The Pirbright Institute, Ash Road, Pirbright GU24 0NF, UK., Lambe T; Oxford Vaccine Group, Department of Paediatrics, Medical Sciences Division, University of Oxford and Chinese Academy of Medical Science (CAMS) Oxford Institute (COI), Oxford OX3 7BN, UK. Electronic address: teresa.lambe@paediatrics.ox.ac.uk., Linterman MA; Lymphocyte Signalling and Development, Babraham Institute, Babraham Research Campus, Cambridge CB22 3AT, UK. Electronic address: michelle.linterman@babraham.ac.uk.

Publikováno v: Cell reports. Medicine [Cell Rep Med] 2022 Dec 20; Vol. 3 (12), pp. 100845. Date of Electronic Publication: 2022 Nov 15.

The receptor PTPRU is a redox sensitive pseudophosphatase.

Autor: Hay IM; Cambridge Institute for Medical Research, Hills Road, Cambridge, CB2 0XY, UK.; Signalling Programme, Babraham Institute, Cambridge, CB22 3AT, UK., Fearnley GW; Cambridge Institute for Medical Research, Hills Road, Cambridge, CB2 0XY, UK.; Signalling Programme, Babraham Institute, Cambridge, CB22 3AT, UK., Rios P; Signalling Research Centres BIOSS and CIBSS, and Faculty of Biology, University of Freiburg, Schänzlestr. 18, Freiburg, D-79104, Germany., Köhn M; Signalling Research Centres BIOSS and CIBSS, and Faculty of Biology, University of Freiburg, Schänzlestr. 18, Freiburg, D-79104, Germany., Sharpe HJ; Cambridge Institute for Medical Research, Hills Road, Cambridge, CB2 0XY, UK. Hayley.sharpe@babraham.ac.uk.; Signalling Programme, Babraham Institute, Cambridge, CB22 3AT, UK. Hayley.sharpe@babraham.ac.uk., Deane JE; Cambridge Institute for Medical Research, Hills Road, Cambridge, CB2 0XY, UK. Jed55@cam.ac.uk.

Publikováno v: Nature communications [Nat Commun] 2020 Jun 26; Vol. 11 (1), pp. 3219. Date of Electronic Publication: 2020 Jun 26.