DNA Barcoding in Nonhuman Primates Reveals Important Limitations in Retrovirus Integration Site Analysis.

Autor: Adair JE; Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA.; School of Medicine, University of Washington, Seattle, WA 98195, USA., Enstrom MR; Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA., Haworth KG; Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA., Schefter LE; Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA., Shahbazi R; Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA., Humphrys DR; Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA., Porter S; Department of Pediatrics, Stanford University, Stanford, CA 94305, USA., Tam K; Department of Pediatrics, Stanford University, Stanford, CA 94305, USA., Porteus MH; Department of Pediatrics, Stanford University, Stanford, CA 94305, USA.; Institute of Stem Cell Biology and Regenerative Medicine, Stanford University, Stanford, CA 94305, USA., Kiem HP; Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA.; School of Medicine, University of Washington, Seattle, WA 98195, USA.

Publikováno v: Molecular therapy. Methods & clinical development [Mol Ther Methods Clin Dev] 2020 Mar 30; Vol. 17, pp. 796-809. Date of Electronic Publication: 2020 Mar 30 (Print Publication: 2020).

Resveratrol trimer enhances gene delivery to hematopoietic stem cells by reducing antiviral restriction at endosomes.

Autor: Ozog S; The Scripps Research Institute, La Jolla, CA., Timberlake ND; The Scripps Research Institute, La Jolla, CA.; Poseida Therapeutics, San Diego, CA., Hermann K; The Scripps Research Institute, La Jolla, CA., Garijo O; The Scripps Research Institute, La Jolla, CA., Haworth KG; Fred Hutchinson Cancer Research Center, Seattle, WA., Shi G; National Cancer Institute, Frederick, MD., Glinkerman CM; The Scripps Research Institute, La Jolla, CA., Schefter LE; Fred Hutchinson Cancer Research Center, Seattle, WA., D'Souza S; Wisconsin National Primate Research Center, Madison, WI., Simpson E; The Scripps Research Institute, La Jolla, CA., Sghia-Hughes G; Fred Hutchinson Cancer Research Center, Seattle, WA., Carillo RR; Fred Hutchinson Cancer Research Center, Seattle, WA., Boger DL; The Scripps Research Institute, La Jolla, CA., Kiem HP; Fred Hutchinson Cancer Research Center, Seattle, WA.; University of Washington, Seattle, WA., Slukvin I; Wisconsin National Primate Research Center, Madison, WI., Ryu BY; St. Jude Children's Research Hospital, Memphis, TN., Sorrentino BP; St. Jude Children's Research Hospital, Memphis, TN., Adair JE; Fred Hutchinson Cancer Research Center, Seattle, WA.; University of Washington, Seattle, WA., Snyder SA; The Scripps Research Institute, Jupiter, FL; and.; University of Chicago, Chicago, IL., Compton AA; National Cancer Institute, Frederick, MD., Torbett BE; The Scripps Research Institute, La Jolla, CA.

Publikováno v: Blood [Blood] 2019 Oct 17; Vol. 134 (16), pp. 1298-1311.

Engineering resistance to CD33-targeted immunotherapy in normal hematopoiesis by CRISPR/Cas9-deletion of CD33 exon 2.

Autor: Humbert O; Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, WA, USA. ohumbert@fredhutch.org., Laszlo GS; Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, WA, USA., Sichel S; Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, WA, USA., Ironside C; Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, WA, USA., Haworth KG; Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, WA, USA., Bates OM; Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, WA, USA., Beddoe ME; Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, WA, USA., Carrillo RR; Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, WA, USA., Kiem HP; Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, WA, USA.; Division of Medical Oncology, Department of Medicine, University of Washington, Seattle, WA, USA., Walter RB; Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, WA, USA.; Division of Hematology, Department of Medicine, University of Washington, Seattle, WA, USA.

Publikováno v: Leukemia [Leukemia] 2019 Mar; Vol. 33 (3), pp. 762-808. Date of Electronic Publication: 2018 Oct 05.

Long-Term Persistence of Anti-HIV Broadly Neutralizing Antibody-Secreting Hematopoietic Cells in Humanized Mice.

Autor: Kuhlmann AS; Stem Cell and Gene Therapy Program, Fred Hutchinson Cancer Research Center, Seattle, WA, 98109-1024, USA., Haworth KG; Stem Cell and Gene Therapy Program, Fred Hutchinson Cancer Research Center, Seattle, WA, 98109-1024, USA., Barber-Axthelm IM; Stem Cell and Gene Therapy Program, Fred Hutchinson Cancer Research Center, Seattle, WA, 98109-1024, USA., Ironside C; Stem Cell and Gene Therapy Program, Fred Hutchinson Cancer Research Center, Seattle, WA, 98109-1024, USA., Giese MA; Stem Cell and Gene Therapy Program, Fred Hutchinson Cancer Research Center, Seattle, WA, 98109-1024, USA., Peterson CW; Stem Cell and Gene Therapy Program, Fred Hutchinson Cancer Research Center, Seattle, WA, 98109-1024, USA; Department of Medicine, University of Washington, Seattle, WA, 98195, USA., Kiem HP; Stem Cell and Gene Therapy Program, Fred Hutchinson Cancer Research Center, Seattle, WA, 98109-1024, USA; Department of Medicine, University of Washington, Seattle, WA, 98195, USA; Department of Pathology, University of Washington, Seattle, WA, 98195, USA. Electronic address: hkiem@fredhutch.org.

Publikováno v: Molecular therapy : the journal of the American Society of Gene Therapy [Mol Ther] 2019 Jan 02; Vol. 27 (1), pp. 164-177. Date of Electronic Publication: 2018 Sep 27.

Minimal conditioning in Fanconi anemia promotes multi-lineage marrow engraftment at 10-fold lower cell doses.

Autor: Haworth KG; Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, WA, USA., Ironside C; Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, WA, USA., Ramirez MA; Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, WA, USA., Weitz S; Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, WA, USA., Beard BC; Rocket Pharmaceuticals Ltd, New York City, NY, USA., Schwartz JD; Rocket Pharmaceuticals Ltd, New York City, NY, USA., Adair JE; Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, WA, USA.; Department of Medicine, University of Washington, Seattle, WA, USA., Kiem HP; Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, WA, USA.; Department of Medicine, University of Washington, Seattle, WA, USA.; Department of Pathology, University of Washington, Seattle, WA, USA.

Publikováno v: The journal of gene medicine [J Gene Med] 2018 Oct; Vol. 20 (10-11), pp. e3050. Date of Electronic Publication: 2018 Oct 01.