Synthetic Sansanmycin Analogues as Potent Mycobacterium tuberculosis Translocase I Inhibitors

Autor: Tran, W, Kusay, AS, Hawkins, PME, Cheung, C-Y, Nagalingam, G, Pujari, V, Ford, DJ, Stoye, A, Ochoa, JL, Audette, RE, Hortle, E, Oehlers, SH, Charman, SA, Linington, RG, Rubin, EJ, Dowson, CG, Roper, DI, Crick, DC, Balle, T, Cook, GM, Britton, WJ, Payne, RJ

Herein, we report the design and synthesis of inhibitors of Mycobacterium tuberculosis (Mtb) phospho-MurNAc-pentapeptide translocase I (MurX), the first membrane-associated step of peptidoglycan synthesis, leveraging the privileged structure of the s

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=od_______363::f5c24932b73e26570e21341238ceeda8
https://hdl.handle.net/10453/154606

Discovery of High Affinity Cyclic Peptide Ligands for Human ACE2 with SARS-CoV-2 Entry Inhibitory Activity.

Autor: Bedding MJ; School of Chemistry, The University of Sydney, Sydney, New South Wales 2006, Australia.; Australian Research Council Centre of Excellence for Innovations in Peptide and Protein Science, The University of Sydney, Sydney, New South Wales 2006, Australia., Franck C; School of Chemistry, The University of Sydney, Sydney, New South Wales 2006, Australia.; Australian Research Council Centre of Excellence for Innovations in Peptide and Protein Science, The University of Sydney, Sydney, New South Wales 2006, Australia.; School of Life and Environmental Sciences, The University of Sydney, Sydney, New South Wales 2006, Australia., Johansen-Leete J; School of Chemistry, The University of Sydney, Sydney, New South Wales 2006, Australia.; Australian Research Council Centre of Excellence for Innovations in Peptide and Protein Science, The University of Sydney, Sydney, New South Wales 2006, Australia., Aggarwal A; Kirby Institute, Sydney, New South Wales 2052, Australia., Maxwell JWC; School of Chemistry, The University of Sydney, Sydney, New South Wales 2006, Australia.; Australian Research Council Centre of Excellence for Innovations in Peptide and Protein Science, The University of Sydney, Sydney, New South Wales 2006, Australia., Patel K; School of Life and Environmental Sciences, The University of Sydney, Sydney, New South Wales 2006, Australia., Hawkins PME; School of Chemistry, The University of Sydney, Sydney, New South Wales 2006, Australia.; Australian Research Council Centre of Excellence for Innovations in Peptide and Protein Science, The University of Sydney, Sydney, New South Wales 2006, Australia., Low JKK; School of Life and Environmental Sciences, The University of Sydney, Sydney, New South Wales 2006, Australia., Siddiquee R; School of Life and Environmental Sciences, The University of Sydney, Sydney, New South Wales 2006, Australia., Sani HM; School of Life and Environmental Sciences, The University of Sydney, Sydney, New South Wales 2006, Australia., Ford DJ; School of Chemistry, The University of Sydney, Sydney, New South Wales 2006, Australia.; Australian Research Council Centre of Excellence for Innovations in Peptide and Protein Science, The University of Sydney, Sydney, New South Wales 2006, Australia., Turville S; Kirby Institute, Sydney, New South Wales 2052, Australia., Mackay JP; School of Life and Environmental Sciences, The University of Sydney, Sydney, New South Wales 2006, Australia., Passioura T; Sydney Analytical Core Research Facility, The University of Sydney, Sydney, New South Wales 2006, Australia., Christie M; School of Life and Environmental Sciences, The University of Sydney, Sydney, New South Wales 2006, Australia.; School of Medical Sciences, The University of Sydney, Sydney, New South Wales 2006, Australia., Payne RJ; School of Chemistry, The University of Sydney, Sydney, New South Wales 2006, Australia.; Australian Research Council Centre of Excellence for Innovations in Peptide and Protein Science, The University of Sydney, Sydney, New South Wales 2006, Australia.

Publikováno v: ACS chemical biology [ACS Chem Biol] 2024 Jan 19; Vol. 19 (1), pp. 141-152. Date of Electronic Publication: 2023 Dec 12.

Clp-targeting BacPROTACs impair mycobacterial proteostasis and survival.

Autor: Hoi DM; Research Institute of Molecular Pathology, Vienna BioCenter, 1030 Vienna, Austria; Max Perutz Labs, Vienna BioCenter, 1030 Vienna, Austria; Vienna BioCenter PhD Program, Doctoral School of the University of Vienna and Medical University of Vienna, 1030 Vienna, Austria; University of Vienna, Center for Molecular Biology, Department for Biochemistry and Cell Biology, 1030 Vienna, Austria., Junker S; Research Institute of Molecular Pathology, Vienna BioCenter, 1030 Vienna, Austria., Junk L; Saarland University, Organic Chemistry I, 66123 Saarbrücken, Germany; Helmholtz Institute for Pharmaceutical Research Saarland (HIPS), Helmholtz Centre for Infection Research (HZI), 66123 Saarbrücken, Germany. Electronic address: lukas.junk@helmholtz-hips.de., Schwechel K; Institute of Pharmaceutical Biology and Biotechnology, Heinrich Heine University, 40225 Düsseldorf, Germany., Fischel K; Boehringer Ingelheim RCV GmbH & Co KG, 1120 Vienna, Austria., Podlesainski D; University of Duisburg-Essen, Center of Medical Biotechnology, Faculty of Biology, 45141 Essen, Germany., Hawkins PME; School of Chemistry, University of Sydney, Sydney, NSW 2006, Australia; Australian Research Council Centre of Excellence for Innovations in Peptide and Protein Science, The University of Sydney, NSW 2006, Australia., van Geelen L; Institute of Pharmaceutical Biology and Biotechnology, Heinrich Heine University, 40225 Düsseldorf, Germany., Kaschani F; University of Duisburg-Essen, Center of Medical Biotechnology, Faculty of Biology, 45141 Essen, Germany., Leodolter J; Research Institute of Molecular Pathology, Vienna BioCenter, 1030 Vienna, Austria., Morreale FE; Research Institute of Molecular Pathology, Vienna BioCenter, 1030 Vienna, Austria., Kleine S; University of Duisburg-Essen, Center of Medical Biotechnology, Faculty of Biology, 45141 Essen, Germany., Guha S; Saarland University, Organic Chemistry I, 66123 Saarbrücken, Germany., Rumpel K; Boehringer Ingelheim RCV GmbH & Co KG, 1120 Vienna, Austria., Schmiedel VM; Boehringer Ingelheim RCV GmbH & Co KG, 1120 Vienna, Austria., Weinstabl H; Boehringer Ingelheim RCV GmbH & Co KG, 1120 Vienna, Austria., Meinhart A; Research Institute of Molecular Pathology, Vienna BioCenter, 1030 Vienna, Austria., Payne RJ; School of Chemistry, University of Sydney, Sydney, NSW 2006, Australia; Australian Research Council Centre of Excellence for Innovations in Peptide and Protein Science, The University of Sydney, NSW 2006, Australia., Kaiser M; University of Duisburg-Essen, Center of Medical Biotechnology, Faculty of Biology, 45141 Essen, Germany., Hartl M; Max Perutz Labs, Vienna BioCenter, 1030 Vienna, Austria; University of Vienna, Center for Molecular Biology, Department for Biochemistry and Cell Biology, 1030 Vienna, Austria., Boehmelt G; Boehringer Ingelheim RCV GmbH & Co KG, 1120 Vienna, Austria., Kazmaier U; Saarland University, Organic Chemistry I, 66123 Saarbrücken, Germany; Helmholtz Institute for Pharmaceutical Research Saarland (HIPS), Helmholtz Centre for Infection Research (HZI), 66123 Saarbrücken, Germany., Kalscheuer R; Institute of Pharmaceutical Biology and Biotechnology, Heinrich Heine University, 40225 Düsseldorf, Germany., Clausen T; Research Institute of Molecular Pathology, Vienna BioCenter, 1030 Vienna, Austria; Medical University of Vienna, 1030 Vienna, Austria. Electronic address: tim.clausen@imp.ac.at.

Publikováno v: Cell [Cell] 2023 May 11; Vol. 186 (10), pp. 2176-2192.e22. Date of Electronic Publication: 2023 May 02.

Synthetic Sansanmycin Analogues as Potent Mycobacterium tuberculosis Translocase I Inhibitors.

Autor: Tran W; School of Chemistry, The University of Sydney, Sydney, NSW 2006, Australia., Kusay AS; Sydney Pharmacy School, Faculty of Medicine and Health, The University of Sydney, Sydney, NSW 2006, Australia.; Brain and Mind Centre, The University of Sydney, Camperdown, NSW 2050, Australia., Hawkins PME; School of Chemistry, The University of Sydney, Sydney, NSW 2006, Australia., Cheung CY; Department of Microbiology and Immunology, School of Biomedical Sciences, University of Otago, Dunedin 9016, New Zealand., Nagalingam G; Centenary Institute and Sydney Medical School, The University of Sydney, Sydney, NSW 2006, Australia., Pujari V; Mycobacteria Research Laboratories, Department of Microbiology, Immunology and Pathology, Colorado State University, Fort Collins, Colorado 80523, United States., Ford DJ; School of Chemistry, The University of Sydney, Sydney, NSW 2006, Australia., Stoye A; School of Chemistry, The University of Sydney, Sydney, NSW 2006, Australia., Ochoa JL; Department of Chemistry and Biochemistry, University of California Santa Cruz, Santa Cruz, California 95064, United States., Audette RE; Department of Immunology and Infectious Diseases, Harvard T. H. Chan School of Public Health, Boston, Massachusetts 02115, United States., Hortle E; Centenary Institute and Sydney Medical School, The University of Sydney, Sydney, NSW 2006, Australia., Oehlers SH; Centenary Institute and Sydney Medical School, The University of Sydney, Sydney, NSW 2006, Australia., Charman SA; Centre for Drug Candidate Optimisation, Monash University, Parkville, VIC 3052, Australia., Linington RG; Department of Chemistry, Simon Fraser University, Burnaby, BC V5A 1S6, Canada., Rubin EJ; Department of Immunology and Infectious Diseases, Harvard T. H. Chan School of Public Health, Boston, Massachusetts 02115, United States., Dowson CG; School of Life Sciences, University of Warwick, Coventry CV4 7AL, U.K., Roper DI; School of Life Sciences, University of Warwick, Coventry CV4 7AL, U.K., Crick DC; Mycobacteria Research Laboratories, Department of Microbiology, Immunology and Pathology, Colorado State University, Fort Collins, Colorado 80523, United States., Balle T; Sydney Pharmacy School, Faculty of Medicine and Health, The University of Sydney, Sydney, NSW 2006, Australia.; Brain and Mind Centre, The University of Sydney, Camperdown, NSW 2050, Australia., Cook GM; Department of Microbiology and Immunology, School of Biomedical Sciences, University of Otago, Dunedin 9016, New Zealand., Britton WJ; Centenary Institute and Sydney Medical School, The University of Sydney, Sydney, NSW 2006, Australia., Payne RJ; School of Chemistry, The University of Sydney, Sydney, NSW 2006, Australia.; Australian Research Council Centre of Excellence for Innovations in Peptide and Protein Science, The University of Sydney, Sydney, NSW 2006, Australia.

Publikováno v: Journal of medicinal chemistry [J Med Chem] 2021 Dec 09; Vol. 64 (23), pp. 17326-17345. Date of Electronic Publication: 2021 Nov 30.

Discovery of Cyclic Peptide Ligands to the SARS-CoV-2 Spike Protein Using mRNA Display.

Autor: Norman A; School of Chemistry, The University of Sydney, Sydney, New South Wales 2006, Australia.; Australian Research Council Centre of Excellence for Innovations in Peptide and Protein Science, The University of Sydney, Sydney, New South Wales 2006, Australia., Franck C; School of Chemistry, The University of Sydney, Sydney, New South Wales 2006, Australia.; Australian Research Council Centre of Excellence for Innovations in Peptide and Protein Science, The University of Sydney, Sydney, New South Wales 2006, Australia.; School of Life and Environmental Sciences, The University of Sydney, Sydney, New South Wales 2006, Australia., Christie M; School of Life and Environmental Sciences, The University of Sydney, Sydney, New South Wales 2006, Australia., Hawkins PME; School of Chemistry, The University of Sydney, Sydney, New South Wales 2006, Australia.; Australian Research Council Centre of Excellence for Innovations in Peptide and Protein Science, The University of Sydney, Sydney, New South Wales 2006, Australia., Patel K; School of Life and Environmental Sciences, The University of Sydney, Sydney, New South Wales 2006, Australia., Ashhurst AS; School of Chemistry, The University of Sydney, Sydney, New South Wales 2006, Australia.; Australian Research Council Centre of Excellence for Innovations in Peptide and Protein Science, The University of Sydney, Sydney, New South Wales 2006, Australia.; School of Medical Sciences, Faculty of Medicine and Health, The University of Sydney, Sydney, New South Wales 2006, Australia., Aggarwal A; Kirby Institute, Sydney, New South Wales 2052, Australia., Low JKK; School of Life and Environmental Sciences, The University of Sydney, Sydney, New South Wales 2006, Australia., Siddiquee R; School of Life and Environmental Sciences, The University of Sydney, Sydney, New South Wales 2006, Australia.; Sydney Analytical, The University of Sydney, Sydney, New South Wales 2006, Australia., Ashley CL; School of Medical Sciences, Faculty of Medicine and Health, The University of Sydney, Sydney, New South Wales 2006, Australia., Steain M; School of Medical Sciences, Faculty of Medicine and Health, The University of Sydney, Sydney, New South Wales 2006, Australia., Triccas JA; School of Medical Sciences, Faculty of Medicine and Health, The University of Sydney, Sydney, New South Wales 2006, Australia., Turville S; Kirby Institute, Sydney, New South Wales 2052, Australia., Mackay JP; School of Life and Environmental Sciences, The University of Sydney, Sydney, New South Wales 2006, Australia., Passioura T; School of Chemistry, The University of Sydney, Sydney, New South Wales 2006, Australia.; School of Life and Environmental Sciences, The University of Sydney, Sydney, New South Wales 2006, Australia.; Sydney Analytical, The University of Sydney, Sydney, New South Wales 2006, Australia., Payne RJ; School of Chemistry, The University of Sydney, Sydney, New South Wales 2006, Australia.; Australian Research Council Centre of Excellence for Innovations in Peptide and Protein Science, The University of Sydney, Sydney, New South Wales 2006, Australia.

Publikováno v: ACS central science [ACS Cent Sci] 2021 Jun 23; Vol. 7 (6), pp. 1001-1008. Date of Electronic Publication: 2021 May 27.