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Organic anion-transporting polypeptides (OATPs) are multispecific transporters mediating the uptake of endogenous compounds and xenobiotics in tissues that are important for drug absorption and elimination, including the intestine and liver. Silymari
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7460ba3c0b40e39d5cde98b06b952e80
Autor:
Hawke, R. L., Kashuba, A. D. M., Hull, J. H., Thirumaran, R. K., Schuetz, E. G., Chen, M.-L., Ilic, K., Stewart, P. W., Lindley, C. M.
The effects of sex, ethnicity, and genetic polymorphism on hepatic CYP2B6 (cytochrome P450 2B6) expression and activity were previously demonstrated in vitro. Race/ethnic differences in CYP2B6 genotype and phenotype were observed only in women. To id
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https://explore.openaire.eu/search/publication?articleId=doi_________::e37442eb77c753fac0b88bed43ba2d1a
Autor:
Doo, E., Schrieber, S. J., Smith, P. C., Wahed, A. S., Afdhal, N. H., Fried, M. W., Wen, Z., Navarro, V. J., Belle, S. H., Reddy, K. R., Hawke, R. L., Meyers, C. M.
Silymarin, derived from the milk thistle plant Silybum marianum and widely used for self-treatment of liver diseases, is composed of six major flavonolignans including silybin A and silybin B, which are the predominant flavonolignans quantified in hu
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https://explore.openaire.eu/search/publication?articleId=doi_________::3dad274d63afa85861a7d3fdad128a2d
Autor:
Paine, M. F., Roberts, P. J., Kashuba, A. D. M., Moran, C., Lamba, J. K., Schuetz, E. G., Hawke, R. L., Williams, E. E., Rollins, K. D., Nelsen, A. C.
The CYP3A5*1 allele has been associated with differences in the metabolism of some CYP3A substrates. CYP3A5 polymorphism may also influence susceptibility for certain drug interactions. We have previously noted a correlation between basal CYP3A activ
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::17c9fb8ca2800e476544a26f55a665a1
Silymarin, an extract from seeds of Silybum marianum, is used by 8-33% of patients to self-treat chronic viral hepatitis C in the United States. Studies in humans and rodents suggest that biliary excretion of glucuronide and sulfate conjugates is the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::dc37bd8e17803f79be62f66cd6d8262b
Akademický článek
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Publikováno v:
Journal of Liquid Chromatography; Jun1986, Vol. 9 Issue 8, p1711-1725, 15p
Publikováno v:
Journal of Liquid Chromatography & Related Technologies; June 1986, Vol. 9 Issue: 8 p1711-1725, 15p
Autor:
Hawke, R L, Welch, R M
Publikováno v:
Molecular Pharmacology; September 1985, Vol. 28 Issue: 3 p283-289, 7p
Akademický článek
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