Deficiency in endocannabinoid synthase DAGLB contributes to early onset Parkinsonism and murine nigral dopaminergic neuron dysfunction.

Autor: Liu Z; Transgenic Section, Laboratory of Neurogenetics, National Institute on Aging, National Institutes of Health, Bethesda, MD, 20892, USA.; Department of Neurology, Xiangya Hospital, Central South University, 410008, Changsha, Hunan, China., Yang N; Transgenic Section, Laboratory of Neurogenetics, National Institute on Aging, National Institutes of Health, Bethesda, MD, 20892, USA.; Department of Neurology, Xiangya Hospital, Central South University, 410008, Changsha, Hunan, China., Dong J; Transgenic Section, Laboratory of Neurogenetics, National Institute on Aging, National Institutes of Health, Bethesda, MD, 20892, USA.; Clinical Research Center on Neurological Diseases, the First Affiliated Hospital, Dalian Medical University, 116011, Dalian, Liaoning, China., Tian W; Transgenic Section, Laboratory of Neurogenetics, National Institute on Aging, National Institutes of Health, Bethesda, MD, 20892, USA.; Department of Neurology, Ruijin Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, 20025, Shanghai, China., Chang L; Transgenic Section, Laboratory of Neurogenetics, National Institute on Aging, National Institutes of Health, Bethesda, MD, 20892, USA., Ma J; Department of Neurology, Xuanwu Hospital of Capital Medical University, 100053, Beijing, China., Guo J; Department of Neurology, Xiangya Hospital, Central South University, 410008, Changsha, Hunan, China., Tan J; Centre for Medical Genetics and Hunan Key Laboratory of Medical Genetics, School of Life Sciences, Central South University, 410008, Changsha, Hunan, China., Dong A; State Key Laboratory of Membrane Biology, Peking University School of Life Sciences, 100871, Beijing, China.; PKU-IDG/McGovern Institute for Brain Research, 100871, Beijing, China.; Peking-Tsinghua Center for Life Sciences, Academy for Advanced Interdisciplinary Studies, Peking University, 100871, Beijing, China., He K; State Key Laboratory of Membrane Biology, Peking University School of Life Sciences, 100871, Beijing, China.; PKU-IDG/McGovern Institute for Brain Research, 100871, Beijing, China., Zhou J; In Vivo Neurobiology Group, Neurobiology Laboratory, National Institute of Environmental Health Sciences, Research Triangle Park, NC, 27709, USA., Cinar R; Laboratory of Physiologic Studies, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Bethesda, MD, 20892, USA., Wu J; Transgenic Section, Laboratory of Neurogenetics, National Institute on Aging, National Institutes of Health, Bethesda, MD, 20892, USA., Salinas AG; Laboratory for Integrative Neuroscience, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Rockville, MD, 20852, USA., Sun L; Transgenic Section, Laboratory of Neurogenetics, National Institute on Aging, National Institutes of Health, Bethesda, MD, 20892, USA., Kumar M; Transgenic Section, Laboratory of Neurogenetics, National Institute on Aging, National Institutes of Health, Bethesda, MD, 20892, USA., Sullivan BT; Transgenic Section, Laboratory of Neurogenetics, National Institute on Aging, National Institutes of Health, Bethesda, MD, 20892, USA., Oldham BB; Transgenic Section, Laboratory of Neurogenetics, National Institute on Aging, National Institutes of Health, Bethesda, MD, 20892, USA., Pitz V; Molecular Genetics Section, Laboratory of Neurogenetics, National Institute on Aging, National Institutes of Health, Bethesda, MD, 20892, USA., Makarious MB; Molecular Genetics Section, Laboratory of Neurogenetics, National Institute on Aging, National Institutes of Health, Bethesda, MD, 20892, USA., Ding J; Computational Biology Group, Laboratory of Neurogenetics, National Institute on Aging, National Institutes of Health, Bethesda, MD, 20892, USA., Kung J; Transgenic Section, Laboratory of Neurogenetics, National Institute on Aging, National Institutes of Health, Bethesda, MD, 20892, USA., Xie C; Transgenic Section, Laboratory of Neurogenetics, National Institute on Aging, National Institutes of Health, Bethesda, MD, 20892, USA., Hawes SL; Transgenic Section, Laboratory of Neurogenetics, National Institute on Aging, National Institutes of Health, Bethesda, MD, 20892, USA., Wang L; Transgenic Section, Laboratory of Neurogenetics, National Institute on Aging, National Institutes of Health, Bethesda, MD, 20892, USA., Wang T; Department of Neurology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, 430022, Wuhan, Hubei, China., Chan P; Department of Neurology, Xuanwu Hospital of Capital Medical University, 100053, Beijing, China., Zhang Z; Centre for Medical Genetics and Hunan Key Laboratory of Medical Genetics, School of Life Sciences, Central South University, 410008, Changsha, Hunan, China.; Department of Neurosciences, University of South China Medical School, 421200, Hengyang, Hunan, China., Le W; Clinical Research Center on Neurological Diseases, the First Affiliated Hospital, Dalian Medical University, 116011, Dalian, Liaoning, China.; Institute of Neurology, Sichuan Academy of Medical Sciences-Sichuan Provincial Hospital, Medical School of University of Electronics & Technology of China, 610045, Chengdu, Sichuan, China., Chen S; Department of Neurology, Ruijin Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, 20025, Shanghai, China., Lovinger DM; Laboratory for Integrative Neuroscience, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Rockville, MD, 20852, USA., Blauwendraat C; Integrative Neurogenomics Unit, Laboratory of Neurogenetics, National Institute on Aging, National Institutes of Health, Bethesda, MD, 20892, USA., Singleton AB; Molecular Genetics Section, Laboratory of Neurogenetics, National Institute on Aging, National Institutes of Health, Bethesda, MD, 20892, USA.; Center for Alzheimer's and Related Dementias, National Institutes of Health, Bethesda, MD, 20892, USA., Cui G; In Vivo Neurobiology Group, Neurobiology Laboratory, National Institute of Environmental Health Sciences, Research Triangle Park, NC, 27709, USA., Li Y; State Key Laboratory of Membrane Biology, Peking University School of Life Sciences, 100871, Beijing, China.; PKU-IDG/McGovern Institute for Brain Research, 100871, Beijing, China.; Peking-Tsinghua Center for Life Sciences, Academy for Advanced Interdisciplinary Studies, Peking University, 100871, Beijing, China.; Chinese Institute for Brain Research, 102206, Beijing, China., Cai H; Transgenic Section, Laboratory of Neurogenetics, National Institute on Aging, National Institutes of Health, Bethesda, MD, 20892, USA. caih@mail.nih.gov., Tang B; Department of Neurology, Xiangya Hospital, Central South University, 410008, Changsha, Hunan, China. bstang7398@163.com.; Centre for Medical Genetics and Hunan Key Laboratory of Medical Genetics, School of Life Sciences, Central South University, 410008, Changsha, Hunan, China. bstang7398@163.com.; National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, 410008, Changsha, Hunan, China. bstang7398@163.com.; Key Laboratory of Hunan Province in Neurodegenerative Disorders, Central South University, 410008, Changsha, Hunan, China. bstang7398@163.com.

Publikováno v: Nature communications [Nat Commun] 2022 Jun 17; Vol. 13 (1), pp. 3490. Date of Electronic Publication: 2022 Jun 17.

Long-term plasticity of corticostriatal synapses is modulated by pathway-specific co-release of opioids through κ-opioid receptors.

Autor: Hawes SL; George Mason University, Krasnow Institute for Advanced Study, Fairfax, VA, 22030-4444, USA., Salinas AG; George Mason University, Krasnow Institute for Advanced Study, Fairfax, VA, 22030-4444, USA.; Laboratory for Integrative Neuroscience, Section on Synaptic Pharmacology, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Rockville, MD, 20852, USA., Lovinger DM; Laboratory for Integrative Neuroscience, Section on Synaptic Pharmacology, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Rockville, MD, 20852, USA., Blackwell KT; George Mason University, Krasnow Institute for Advanced Study, Fairfax, VA, 22030-4444, USA.

Publikováno v: The Journal of physiology [J Physiol] 2017 Aug 15; Vol. 595 (16), pp. 5637-5652. Date of Electronic Publication: 2017 May 26.

Calcium-dependent inactivation of calcium channels in the medial striatum increases at eye opening.

Autor: Evans RC; George Mason University, The Krasnow Institute for Advanced Studies, Fairfax, Virginia; and., Herin GA; Eastern Mennonite University, Harrisonburg, Virginia., Hawes SL; George Mason University, The Krasnow Institute for Advanced Studies, Fairfax, Virginia; and., Blackwell KT; George Mason University, The Krasnow Institute for Advanced Studies, Fairfax, Virginia; and kblackw1@gmu.edu.

Publikováno v: Journal of neurophysiology [J Neurophysiol] 2015 Apr 01; Vol. 113 (7), pp. 2979-86. Date of Electronic Publication: 2015 Feb 11.

Signaling pathways involved in striatal synaptic plasticity are sensitive to temporal pattern and exhibit spatial specificity.

Autor: Kim B; School of Mechanical Engineering, University of Ulsan, Ulsan, South Korea., Hawes SL, Gillani F, Wallace LJ, Blackwell KT

Publikováno v: PLoS computational biology [PLoS Comput Biol] 2013; Vol. 9 (3), pp. e1002953. Date of Electronic Publication: 2013 Mar 14.