Zobrazeno 1 - 10
of 124
pro vyhledávání: '"Hawerkamp, A."'
Autor:
Clive Drakeford, Sonia Aguila, Fiona Roche, Karsten Hokamp, Judicael Fazavana, Mariana P. Cervantes, Annie M. Curtis, Heike C. Hawerkamp, Sukhraj Pal Singh Dhami, Hugo Charles-Messance, Emer E. Hackett, Alain Chion, Soracha Ward, Azaz Ahmad, Ingmar Schoen, Eamon Breen, Joe Keane, Ross Murphy, Roger J. S. Preston, Jamie M. O’Sullivan, Frederick J. Sheedy, Padraic Fallon, James S. O’Donnell
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-19 (2022)
von Willebrand factor (VWF) plays a critical role in primary hemostasis following vascular injury by tethering platelets to exposed collagen. Here, VWF binding to macrophages is shown to trigger NF-κB activation and induce pro-inflammatory responses
Externí odkaz:
https://doaj.org/article/0abf998c232d43bcab767dde021ae471
Akademický článek
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Autor:
Heike C. Hawerkamp, Adam H. Dyer, Neha D. Patil, Matt McElheron, Niamh O’Dowd, Laura O’Doherty, Aisling Ui Mhaonaigh, Angel M. George, Aisling M. O’Halloran, Conor Reddy, Rose Anne Kenny, Mark A. Little, Ignacio Martin-Loeches, Colm Bergin, Sean P. Kennelly, Seamas C. Donnelly, Nollaig M. Bourke, Aideen Long, Jacklyn Sui, Derek G. Doherty, Niall Conlon, Cliona Ni Cheallaigh, Padraic G. Fallon
Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
Clinical outcomes from infection with SARS-CoV-2, the cause of the COVID-19 pandemic, are remarkably variable ranging from asymptomatic infection to severe pneumonia and death. One of the key drivers of this variability is differing trajectories in t
Externí odkaz:
https://doaj.org/article/55a248964b0f4c47b23b9c07a22af0be
Autor:
Alessio Mylonas, Heike C. Hawerkamp, Yichen Wang, Jiaqi Chen, Francesco Messina, Olivier Demaria, Stephan Meller, Bernhard Homey, Jeremy Di Domizio, Lucia Mazzolai, Alain Hovnanian, Michel Gilliet, Curdin Conrad
Publikováno v:
JCI Insight, Vol 8, Iss 4 (2023)
Rosacea is a common chronic inflammatory skin disease with a fluctuating course of excessive inflammation and apparent neovascularization. Microbial dysbiosis with a high density of Bacillus oleronius and increased activity of kallikrein 5, which cle
Externí odkaz:
https://doaj.org/article/d033bfd462684a7e9f4fe0c374da5b1b
Autor:
Heike C. Hawerkamp, Alina Domdey, Lisa Radau, Philipp Sewerin, Péter Oláh, Bernhard Homey, Stephan Meller
Publikováno v:
Arthritis Research & Therapy, Vol 23, Iss 1, Pp 1-12 (2021)
Abstract Background Tofacitinib is a novel Janus kinase (JAK) inhibitor approved for the treatment of rheumatoid arthritis, psoriatic arthritis, and ulcerative colitis. In clinical trials, the most common adverse events observed were nasopharyngitis,
Externí odkaz:
https://doaj.org/article/db036183d5b742958b42a6cb156bea3c
Break on through: The role of innate immunity and barrier defence in atopic dermatitis and psoriasis
Publikováno v:
Skin Health and Disease, Vol 2, Iss 2, Pp n/a-n/a (2022)
Abstract The human skin can be affected by a multitude of diseases including inflammatory conditions such as atopic dermatitis and psoriasis. Here, we describe how skin barrier integrity and immunity become dysregulated during these two most common i
Externí odkaz:
https://doaj.org/article/b12b3ff08b0242b7ac83f9c0559436dd
Autor:
Clíona Ní Cheallaigh, Laura O'Doherty, Nicole Wood, Stuart Hendricken Phelan, Jacklyn Sui, Sorcha O'Brien, Fergal Howley, Cian Mangan, Noor Adeebah Mohamed Razif, Siobhan O'Regan, Ruth Argue, Ciara Conlan, Adam Dyer, Samuel Holohan, Roman Romero-Ortuno, Liam Townsend, Fara Salleh, Colm Kerr, Gerard Hughes, Alberto Sanz, Derval Reidy, Andrea Kelly, Emma Connolly, Siobhan Gargan, Conor Reddy, Heike Hawerkamp, Eamon Breen, Ignacio Martin-Loeches, Jean Dunne, Aideen Long, Anne Marie McLaughlin, Padraic Fallon, Orla Shiels, Ciaran Bannan, Martina Hennessy, Ana Rakovac, Anna Rose Prior, Ross McManus, William McCormack, Colm Bergin, Seamus Donnelly, Mark Little, Emma Leacy, Niall Conlon
Publikováno v:
HRB Open Research, Vol 5 (2022)
Background: The current coronavirus disease 2019 (COVID-19) pandemic began in Ireland with the first confirmed positive case in March 2020. In the early stages of the pandemic clinicians and researchers in two affiliated Dublin hospitals identified t
Externí odkaz:
https://doaj.org/article/f3611967469d4829b773b45897958a77
Akademický článek
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Autor:
Ruth Bone, Brian J Fennell, Amy Tam, Richard Sheldon, Karl Nocka, Sreeja Varghese, Chew Shun Chang, Heike C Hawerkamp, Aoife Yeow, Sean P Saunders, Emily Hams, Patrick T Walsh, Orla Cunningham, Padraic G Fallon
Publikováno v:
Antibody Therapeutics. 5:258-267
Background Interleukin (IL)25 has been implicated in tissue homeostasis at barrier surfaces and the initiation of type two inflammatory signaling in response to infection and cell injury across multiple organs. We sought to discover and engineer a hi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eed95ecf98910c10515eaea5f5988f79
https://doi.org/10.1093/abt/tbac022
https://doi.org/10.1093/abt/tbac022
Akademický článek
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