Výsledky vyhledávání

Polyamine deficient diet to relieve pain hypersensitivity

Autor: Emilie Laboureyras, Jean Paul Laulin, Guy Simonnet, Havouis R, Florence Noble, Philippe Richebé, J.-P. Moulinoux, Cyril Rivat

Publikováno v: Pain. 137:125-137

There is a compelling body of evidence that N-methyl-d-aspartate receptors (NMDA-R) play a critical role in the development and maintenance of pain hypersensitivity. However, long-term treatments with NMDA-R antagonists are limited by unacceptable si

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::266fd85e925732a91f4675a3f70e70c2
https://doi.org/10.1016/j.pain.2007.08.021

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The new orally active iron chelator ICL670A exhibits a higher antiproliferative effect in human hepatocyte cultures than O-trensox

Autor: Havouis R, François Gaboriau, Pierre Brissot, N. Pasdeloup, Jean-Louis Pierre, Hanspeter Nick, Gérard Lescoat, Karine Chantrel-Groussard

Publikováno v: European Journal of Pharmacology. 541:129-137

By comparing the antiproliferative effect of the iron chelators ICL670A and O-trensox in the human hepatoma cell line HUH7 and human hepatocyte cultures, we have shown that ICL670A decreased cell viability, inhibited DNA replication and induced DNA f

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a91feded46ad9dc0f9db9fb0d5f91c76
https://doi.org/10.1016/j.ejphar.2006.05.001

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Dimethylsilane polyamines, a new class of potential anticancer drugs

Autor: Michel Vaultier, Nikolaus Seiler, N LeRoch, Moulinoux Jp, Jacques Renault, F Douaud, Havouis R

Publikováno v: International journal of oncology. 11(4)

Several members of a new class of structural analogues of the natural polyamines which contain a S1(CH3)(2)- group in the central carbon chain have previously been found to be potent cytostatics to various tumor cell lines. These compounds have been

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aabb64af24e253beb4c9e568796b1f1a
https://pubmed.ncbi.nlm.nih.gov/21528282

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Atmospheric pressure chemical ionization-mass spectrometry method to improve the determination of dansylated polyamines

Autor: Havouis R, Jean-Guy Delcros, Jacques-Philippe Moulinoux, François Gaboriau

Publikováno v: Analytical biochemistry. 318(2)

Determination of polyamine pools is still a step impossible to circumvent in studies aimed at determining the pathophysiological role of natural polyamines. In addition, polyamine measurement in biological fluids and tissues may have clinical relevan

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6f2762a2e1f30fd72ccec1c9755abb52
https://pubmed.ncbi.nlm.nih.gov/12814624

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Dimethylsilane polyamines: cytostatic compounds with potentials as anticancer drugs. II. Uptake and potential cytotoxic mechanisms

Autor: Le Roch N, Douaud F, Havouis R, jean-guy delcros, Vaultier M, Jp, Moulinoux, Seiler N

Publikováno v: Europe PubMed Central

Dimethylsilane tetramines are structural analogues of spermine with a (CH3)2 Si-group incorporated into the central carbon chain. They have potential as anticancer drugs. Their cytotoxic effect was considered to rely mainly on their polyamine antagon

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::9741ec9158ffc2dbdf7df4a8aacc2a1d
https://pubmed.ncbi.nlm.nih.gov/12552990

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Accumulation of hydroxyspermidine in red blood cells, a potential index of tumor proliferation rate

Autor: Leveque J, jean-guy delcros, Havouis R, Quemener V, Vaultier M, Seiler N, Jp, Moulinoux

Publikováno v: Europe PubMed Central

It has previously been demonstrated that during Lewis Lung carcinoma growth, red blood cell spermidine levels increase concomitantly with tumor volume. If [14C] putrescine or 2-methylputrescine are administered, [14C] spermidine and methylspermidine,

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::4e8bf5cf1919110478192fddd5db4686
https://pubmed.ncbi.nlm.nih.gov/9042251

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Three dimensional culture of pineal cell aggregates: a model of cell-cell co-operation

Autor: Havouis R, Naim Akhtar Khan, Valiollah Shacoori, Jacques-P.-H. Moulinoux, Dominique Querné, Bernard Rault

Publikováno v: Journal of neuroendocrinology. 7(5)

Three dimensional (3-D) cultures of pineal cell aggregates were obtained by constant gyratory shaking the heterogenous cell populations, obtained from the rat pineals, in the DMEM (Dulbecco's modified Eagle's medium). Within 4 days, the pineal cells

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::33dde328e54b6c60a2b7289fa80f4581
https://pubmed.ncbi.nlm.nih.gov/7550281

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