Aberrant phase separation is a common killing strategy of positively charged peptides in biology and human disease.

Autor: Boeynaems S; Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX 77030, USA.; Jan and Dan Duncan Neurological Research Institute, Texas Children's Hospital, Houston, TX 77030, USA.; Therapeutic Innovation Center (THINC), Baylor College of Medicine, Houston, TX 77030, USA.; Center for Alzheimer's and Neurodegenerative Diseases (CAND), Texas Children's Hospital, Houston, TX 77030, USA.; Dan L Duncan Comprehensive Cancer Center (DLDCCC), Baylor College of Medicine, Houston, TX 77030, USA.; Department of Genetics, Stanford University School of Medicine, Stanford, CA 94305, USA., Ma XR; Department of Genetics, Stanford University School of Medicine, Stanford, CA 94305, USA., Yeong V; Department of Chemical Engineering, Columbia University, New York, NY, 10027, USA., Ginell GM; Department of Biochemistry and Molecular Biophysics, Washington University School of Medicine, St. Louis, MO 63110, USA.; Center for Biomolecular Condensates, Washington University in St Louis, St. Louis, MO 63130, USA., Chen JH; Molecular Biophysics and Integrated Bioimaging Division, Lawrence Berkeley National Laboratory, Berkeley, CA 94720, USA.; Department of Anatomy, University of California, San Francisco, CA 94143, USA., Blum JA; Department of Genetics, Stanford University School of Medicine, Stanford, CA 94305, USA., Nakayama L; Department of Genetics, Stanford University School of Medicine, Stanford, CA 94305, USA., Sanyal A; Department of Genetics, Stanford University School of Medicine, Stanford, CA 94305, USA., Briner A; Clem Jones Centre for Ageing Dementia Research (CJCADR), Queensland Brain Institute (QBI), The University of Queensland, Brisbane, QLD 4072, Australia., Haver DV; VIB-UGent Center for Medical Biotechnology, 9000 Gent, Belgium.; VIB Proteomics Core, 9000 Gent, Belgium.; Department of Biochemistry, Ghent University, 9000 Gent, Belgium., Pauwels J; VIB-UGent Center for Medical Biotechnology, 9000 Gent, Belgium.; VIB Proteomics Core, 9000 Gent, Belgium.; Department of Biochemistry, Ghent University, 9000 Gent, Belgium., Ekman A; Molecular Biophysics and Integrated Bioimaging Division, Lawrence Berkeley National Laboratory, Berkeley, CA 94720, USA.; Department of Anatomy, University of California, San Francisco, CA 94143, USA., Schmidt HB; Department of Biochemistry, Stanford University School of Medicine, Stanford, CA 94305, USA., Sundararajan K; Department of Biochemistry, Stanford University School of Medicine, Stanford, CA 94305, USA., Porta L; Department of Pharmacology, Escola Paulista de Medicina (EPM), Universidade Federal de São Paulo (UNIFESP), Sao Paulo, Brazil., Lasker K; Department of Integrative Structural and Computational Biology, The Scripps Research Institute, La Jolla, CA 92037, USA., Larabell C; Molecular Biophysics and Integrated Bioimaging Division, Lawrence Berkeley National Laboratory, Berkeley, CA 94720, USA.; Department of Anatomy, University of California, San Francisco, CA 94143, USA., Hayashi MAF; Department of Pharmacology, Escola Paulista de Medicina (EPM), Universidade Federal de São Paulo (UNIFESP), Sao Paulo, Brazil., Kundaje A; Department of Genetics, Stanford University School of Medicine, Stanford, CA 94305, USA.; Department of Computer Science, Stanford University, Stanford, CA 94305, USA., Impens F; VIB-UGent Center for Medical Biotechnology, 9000 Gent, Belgium.; VIB Proteomics Core, 9000 Gent, Belgium.; Department of Biochemistry, Ghent University, 9000 Gent, Belgium., Obermeyer A; Department of Chemical Engineering, Columbia University, New York, NY, 10027, USA., Holehouse AS; Department of Biochemistry and Molecular Biophysics, Washington University School of Medicine, St. Louis, MO 63110, USA.; Center for Biomolecular Condensates, Washington University in St Louis, St. Louis, MO 63130, USA., Gitler AD; Department of Genetics, Stanford University School of Medicine, Stanford, CA 94305, USA.; Chan Zuckerberg Biohub, San Francisco, CA 94158, USA.

Publikováno v: BioRxiv : the preprint server for biology [bioRxiv] 2023 Mar 09. Date of Electronic Publication: 2023 Mar 09.