Zobrazeno 1 - 10
of 25
pro vyhledávání: '"Havell Markus"'
Autor:
Daniel McGuire, Havell Markus, Lina Yang, Jingyu Xu, Austin Montgomery, Arthur Berg, Qunhua Li, Laura Carrel, Dajiang J. Liu, Bibo Jiang
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-14 (2024)
Abstract Large national-level electronic health record (EHR) datasets offer new opportunities for disentangling the role of genes and environment through deep phenotype information and approximate pedigree structures. Here we use the approximate geog
Externí odkaz:
https://doaj.org/article/5f8ed87bcbd74723b6497aa8eb0545e4
Autor:
Lida Wang, Chachrit Khunsriraksakul, Havell Markus, Dieyi Chen, Fan Zhang, Fang Chen, Xiaowei Zhan, Laura Carrel, Dajiang. J. Liu, Bibo Jiang
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-13 (2024)
Abstract Transcriptome-wide association study (TWAS) is a popular approach to dissect the functional consequence of disease associated non-coding variants. Most existing TWAS use bulk tissues and may not have the resolution to reveal cell-type specif
Externí odkaz:
https://doaj.org/article/67437dd5a77c45ce99e21197975f2a6c
Autor:
Xiaoguang Xu, Chachrit Khunsriraksakul, James M. Eales, Sebastien Rubin, David Scannali, Sushant Saluja, David Talavera, Havell Markus, Lida Wang, Maciej Drzal, Akhlaq Maan, Abigail C. Lay, Priscilla R. Prestes, Jeniece Regan, Avantika R. Diwadkar, Matthew Denniff, Grzegorz Rempega, Jakub Ryszawy, Robert Król, John P. Dormer, Monika Szulinska, Marta Walczak, Andrzej Antczak, Pamela R. Matías-García, Melanie Waldenberger, Adrian S. Woolf, Bernard Keavney, Ewa Zukowska-Szczechowska, Wojciech Wystrychowski, Joanna Zywiec, Pawel Bogdanski, A. H. Jan Danser, Nilesh J. Samani, Tomasz J. Guzik, Andrew P. Morris, Dajiang J. Liu, Fadi J. Charchar, Human Kidney Tissue Resource Study Group, Maciej Tomaszewski
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-29 (2024)
Abstract Genetic mechanisms of blood pressure (BP) regulation remain poorly defined. Using kidney-specific epigenomic annotations and 3D genome information we generated and validated gene expression prediction models for the purpose of transcriptome-
Externí odkaz:
https://doaj.org/article/f5e9da19c88d4024b4071ce5130ced06
Autor:
Chachrit Khunsriraksakul, Qinmengge Li, Havell Markus, Matthew T. Patrick, Renan Sauteraud, Daniel McGuire, Xingyan Wang, Chen Wang, Lida Wang, Siyuan Chen, Ganesh Shenoy, Bingshan Li, Xue Zhong, Nancy J. Olsen, Laura Carrel, Lam C. Tsoi, Bibo Jiang, Dajiang J. Liu
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-14 (2023)
The genetic basis of systemic lupus erythematosus is not completely understood. Here, the authors perform multi-ancestry and multi-trait meta-analyses to identify 16 novel genetic loci and demonstrate the utility of polygenic risk score in clinical r
Externí odkaz:
https://doaj.org/article/967b70f77d724ef59ee7f509410de467
Autor:
Morris A. Aguilar, Shauna Ebanks, Havell Markus, Mechelle M. Lewis, Vishal Midya, Kent Vrana, Xuemei Huang, Molly A. Hall, Yuka Imamura Kawasawa
Publikováno v:
Frontiers in Neuroscience, Vol 17 (2023)
BackgroundCirculating small RNAs (smRNAs) originate from diverse tissues and organs. Previous studies investigating smRNAs as potential biomarkers for Parkinson’s disease (PD) have yielded inconsistent results. We investigated whether smRNA profile
Externí odkaz:
https://doaj.org/article/313c638db17f417b971da0f5798c8ee5
Autor:
Havell Markus, Dineika Chandrananda, Elizabeth Moore, Florent Mouliere, James Morris, James D. Brenton, Christopher G. Smith, Nitzan Rosenfeld
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-11 (2022)
Abstract Circulating tumor DNA (ctDNA) in blood plasma is present at very low concentrations compared to cell-free DNA (cfDNA) of non-tumor origin. To enhance ctDNA detection, recent studies have been focused on understanding the non-random fragmenta
Externí odkaz:
https://doaj.org/article/bb0d9e68990945f2a44c3501647cf6f3
Publikováno v:
Biomedicines, Vol 11, Iss 8, p 2326 (2023)
Ampullary adenocarcinoma is a rare malignancy that lacks standard systemic treatment. We describe a case of recurrent metastatic ampullary adenocarcinoma of the pancreaticobiliary subtype treated with nanoparticle albumin-bound (nab)-paclitaxel and g
Externí odkaz:
https://doaj.org/article/dc635bd1a61a4f2e832efe51d57f1de8
Autor:
Chachrit Khunsriraksakul, Havell Markus, Nancy J. Olsen, Laura Carrel, Bibo Jiang, Dajiang J. Liu
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
Genome-wide association studies (GWAS) have identified hundreds of genetic variants associated with autoimmune diseases and provided unique mechanistic insights and informed novel treatments. These individual genetic variants on their own typically c
Externí odkaz:
https://doaj.org/article/c0ae44938d0b470090f7f81a1c26e622
Autor:
Havell Markus, Tania Contente-Cuomo, Maria Farooq, Winnie S. Liang, Mitesh J. Borad, Shivan Sivakumar, Simon Gollins, Nhan L. Tran, Harshil D. Dhruv, Michael E. Berens, Alan Bryce, Aleksandar Sekulic, Antoni Ribas, Jeffrey M. Trent, Patricia M. LoRusso, Muhammed Murtaza
Publikováno v:
Scientific Reports, Vol 8, Iss 1, Pp 1-10 (2018)
Abstract Pre-analytical factors can significantly affect circulating cell-free DNA (cfDNA) analysis. However, there are few robust methods to rapidly assess sample quality and the impact of pre-analytical processing. To address this gap and to evalua
Externí odkaz:
https://doaj.org/article/754bebe0d60d4db2a753e90d4a1c1a88
Autor:
Leticia De Mattos-Arruda, Stephen-John Sammut, Edith M. Ross, Rachael Bashford-Rogers, Erez Greenstein, Havell Markus, Sandro Morganella, Yvonne Teng, Yosef Maruvka, Bernard Pereira, Oscar M. Rueda, Suet-Feung Chin, Tania Contente-Cuomo, Regina Mayor, Alexandra Arias, H. Raza Ali, Wei Cope, Daniel Tiezzi, Aliakbar Dariush, Tauanne Dias Amarante, Dan Reshef, Nikaoly Ciriaco, Elena Martinez-Saez, Vicente Peg, Santiago Ramon y Cajal, Javier Cortes, George Vassiliou, Gad Getz, Serena Nik-Zainal, Muhammed Murtaza, Nir Friedman, Florian Markowetz, Joan Seoane, Carlos Caldas
Publikováno v:
Cell Reports, Vol 27, Iss 9, Pp 2690-2708.e10 (2019)
Summary: The detailed molecular characterization of lethal cancers is a prerequisite to understanding resistance to therapy and escape from cancer immunoediting. We performed extensive multi-platform profiling of multi-regional metastases in autopsie
Externí odkaz:
https://doaj.org/article/caa33a84a1a642cdaf3f8314c1e4dd94