Accelerated Wound Healing in Minipigs by On-Site Production and Delivery of CXCL12 by Transformed Lactic Acid Bacteria

Autor: Emelie Öhnstedt, Hava Lofton Tomenius, Peter Frank, Stefan Roos, Evelina Vågesjö, Mia Phillipson

Publikováno v: Pharmaceutics, Vol 14, Iss 2, p 229 (2022)

Non-healing wounds are a growing medical problem and result in considerable suffering. The lack of pharmaceutical treatment options reflects the multistep wound healing process, and the complexity of both translation and assessment of treatment effic

Externí odkaz: https://doaj.org/article/29038c80446a4e87a17339340f9e88c3

Mechanisms and fitness costs of resistance to antimicrobial peptides LL-37, CNY100HL and wheat germ histones.

Autor: Hava Lofton, Maria Pränting, Elisabeth Thulin, Dan I Andersson

Publikováno v: PLoS ONE, Vol 8, Iss 7, p e68875 (2013)

Antimicrobial peptides (AMPs) represent a potential new class of antimicrobial drugs with potent and broad-spectrum activities. However, knowledge about the mechanisms and rates of resistance development to AMPs and the resulting effects on fitness a

Externí odkaz: https://doaj.org/article/9e6c9a78ddf345c7b408610504727c48

Oral administration of CXCL12-expressing Limosilactobacillus reuteri improves colitis by local immunomodulatory actions in preclinical models.

Autor: Öhnstedt, Emelie, Doñas, Cristian, Parv, Kristel, Yanhong Pang, Tomenius, Hava Lofton, Lopez, Macarena Carrasco, Gannavarapu, Venkata Ram, Choi, Jacueline, Ovezik, Maria, Frank, Peter, Jorvid, Margareth, Roos, Stefan, Vågesjö, Evelina, Phillipson, Mia

Publikováno v: American Journal of Physiology: Gastrointestinal & Liver Physiology; Aug2024, Vol. 327 Issue 2, pG140-G153, 14p

Reverting Colitis Symptoms by Oral Administration of L. reuteri Expressing CXCL12 Acting Through Novel Pathway Demonstrated in Two Experimental Animal Models

Autor: Emelie Öhnstedt, Cristian Donas Cuadra, Hava Lofton Tomenius, Peter Frank, Evelina Vågesjö, Stefan Roos, Mia Phillipson

Publikováno v: The FASEB Journal. 36

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::0b77e121eb9cf6b764d5d5e289ebbfda
https://doi.org/10.1096/fasebj.2022.36.s1.l7872

Antimicrobial peptide exposure selects for Staphylococcus aureus resistance to human defence peptides

Autor: Jessica Z. Kubicek-Sutherland, Karin Hjort, Hava Lofton, Dan I. Andersson, Martin Vestergaard, Hanne Ingmer

Publikováno v: Kubicek-Sutherland, J Z, Lofton, H, Vestergaard, M, Hjort, K, Ingmer, H & Anderson, D I 2017, ' Antimicrobial peptide exposure selects for Staphylococcus aureus resistance to human defence peptides ', Journal of Antimicrobial Chemotherapy, vol. 72, no. 1, pp. 115-127 . https://doi.org/10.1093/jac/dkw381
Journal of Antimicrobial Chemotherapy

Background: The clinical development of antimicrobial peptides (AMPs) is currently under evaluation to combat the rapid increase in MDR bacterial pathogens. However, many AMPs closely resemble components of the humaninnate immune system and the ramif

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::049777ef5a9fad2643f1ed7d06543d02
https://curis.ku.dk/ws/files/166158008/J_Antimicrob_Chemother_2016_Kubicek_Sutherland_jac_dkw381.pdf