Etude des mécanismes inflammatoires, génétiques et épigénétiques impliqués dans la physiopathologie de l'hypertension artérielle pulmonaire

Autor: Hautefort, Aurélie

L’Hypertensions Artérielle Pulmonaire (HTAP) résulte de l’obstruction progressive des artères pulmonaires de petits calibres due à un remodelage de la paroi vasculaire ainsi qu’à une vasoconstriction. Cette thèse repose sur 3 piliers de l

Externí odkaz: http://www.theses.fr/2017SACLS278

Inflammation in pulmonary hypertension: what we know and what we could logically and safely target first

Autor: Cohen-Kaminsky, Sylvia, Hautefort, Aurélie, Price, Laura, Humbert, Marc, Perros, Frédéric

Publikováno v: In Drug Discovery Today August 2014 19(8):1251-1256

In vivo miR-138-5p inhibition alleviates monocrotaline-induced pulmonary hypertension and normalizes pulmonary KCNK3 and SLC45A3 expression

Autor: Le Ribeuz, Hélène, Courboulin, Audrey, Ghigna, Maria-Rosa, Lambert, Mélanie, Hautefort, Aurélie, Humbert, Marc, Montani, David, Cohen-Kaminsky, Sylvia, Perros , Frédéric, Antigny, Fabrice

Publikováno v: Respiratory Research
Respiratory Research, BioMed Central, 2020, 21, ⟨10.1186/s12931-020-01444-7⟩
Respiratory Research, Vol 21, Iss 1, Pp 1-14 (2020)

International audience; Background: The pathogenesis of pulmonary arterial hypertension (PAH) involves many signalling pathways. MicroRNAs are potential candidates involved in simultaneously coordinating multiple genes under such multifactorial condi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::ac5233882678129c784cda323c71d34d
https://pubmed.ncbi.nlm.nih.gov/32678044

KLF4-induced connexin40 expression contributes to arterial endothelial quiescence

Autor: Denis, Jean-François, Diagbouga, Mannekomba R., Molica, Filippo, Hautefort, Aurélie, Linnerz, Tanja, Watanabe, Masakatsu, Lemeille, Sylvain, Bertrand, Julien Y., Kwak, Brenda R.

Publikováno v: Frontiers in Physiology, Vol. 10, No 80 (2019) pp. 1-13
Frontiers in Physiology

Shear stress, a blood flow-induced frictional force, is essential in the control of endothelial cell (EC) homeostasis. High laminar shear stress (HLSS), as observed in straight parts of arteries, assures a quiescent non-activated endothelium through

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::0b2aeee62082c0790b3ca6db82910797
https://archive-ouverte.unige.ch/unige:118830

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