Zobrazeno 1 - 10
of 26
pro vyhledávání: '"Hauke S. Hillen"'
Autor:
Florian A. Jochheim, Dimitry Tegunov, Hauke S. Hillen, Jana Schmitzová, Goran Kokic, Christian Dienemann, Patrick Cramer
Publikováno v:
Communications Biology, Vol 4, Iss 1, Pp 1-5 (2021)
Jochheim et al report an alternative, dimeric form of the coronavirus SARS-CoV-2 RNA dependent RNA polymerase (RdRp), which is used to replicate and transcribe its genome. They resolve its structure at 5.5 Å resolution and speculate that the dimer f
Externí odkaz:
https://doaj.org/article/72c6389f55874b8695d625c32dbc3d02
Autor:
Hauke S. Hillen, Elena Lavdovskaia, Franziska Nadler, Elisa Hanitsch, Andreas Linden, Katherine E. Bohnsack, Henning Urlaub, Ricarda Richter-Dennerlein
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-10 (2021)
Maturation of the ribosomal peptidyl transferase center (PTC) is mediated by universally conserved GTPases. Here, cryo-EM structures of mitochondrial ribosomal large subunit assembly intermediates and of mature ribosomes offer insight into the roles
Externí odkaz:
https://doaj.org/article/bc353a11e2254ccf9d5c1524e48f6a3c
Autor:
Goran Kokic, Hauke S. Hillen, Dimitry Tegunov, Christian Dienemann, Florian Seitz, Jana Schmitzova, Lucas Farnung, Aaron Siewert, Claudia Höbartner, Patrick Cramer
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-7 (2021)
Remdesivir is a nucleoside analog that inhibits the SARS-CoV-2 RNA dependent RNA polymerase (RdRp) and is used as a drug to treat COVID19 patients. Here, the authors provide insights into the mechanism of remdesivir-induced RdRp stalling by determini
Externí odkaz:
https://doaj.org/article/8b3f1fceaaca4cfa95f1314132c6731b
Autor:
Yvonne Wohlfarter, Reiner Eidelpes, Ryan D. Yu, Sabrina Sailer, Jakob Koch, Daniela Karall, Sabine Scholl-Bürgi, Albert Amberger, Hauke S. Hillen, Johannes Zschocke, Markus A. Keller
Publikováno v:
Cellular and Molecular Life Sciences. 80
Autor:
Hauke S. Hillen
Publikováno v:
Methods in Molecular Biology ISBN: 9781071631706
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a7c18bdfe7f52f40f3470577c60113e2
https://doi.org/10.1007/978-1-0716-3171-3_6
https://doi.org/10.1007/978-1-0716-3171-3_6
Autor:
Goran Kokic, Patrick Cramer, Claudia Höbartner, Jana Schmitzová, Hauke S. Hillen, Carina Stiller, Christian Dienemann, Florian Kabinger
Publikováno v:
Nature Structural & Molecular Biology
Signal Transduction and Targeted Therapy
Nature Structural and Molecular Biology
Signal Transduction and Targeted Therapy
Nature Structural and Molecular Biology
Molnupiravir is an orally available antiviral drug candidate currently in phase III trials for the treatment of patients with COVID-19. Molnupiravir increases the frequency of viral RNA mutations and impairs SARS-CoV-2 replication in animal models an
Autor:
Yvonne Wohlfarter, Reiner Eidelpes, Ryan D. Yu, Sabrina Sailer, Jakob Koch, Daniela Karall, Sabine Scholl-Bürgi, Albert Amberger, Hauke S. Hillen, Johannes Zschocke, Markus A. Keller
Publikováno v:
Cellular and Molecular Life Sciences
Multifunctional proteins are challenging as it can be difficult to confirm pathomechanisms associated with disease-causing genetic variants. The human 17β-hydroxysteroid dehydrogenase 10 (HSD10) is a moonlighting enzyme with at least two structurall
Autor:
Yvonne, Wohlfarter, Reiner, Eidelpes, Ryan D, Yu, Sabrina, Sailer, Jakob, Koch, Daniela, Karall, Sabine, Scholl-Bürgi, Albert, Amberger, Hauke S, Hillen, Johannes, Zschocke, Markus A, Keller
Publikováno v:
Cellular and molecular life sciences : CMLS. 79(11)
Multifunctional proteins are challenging as it can be difficult to confirm pathomechanisms associated with disease-causing genetic variants. The human 17β-hydroxysteroid dehydrogenase 10 (HSD10) is a moonlighting enzyme with at least two structurall
Publikováno v:
Trends in Cell Biology
Final maturation steps during ribosome biogenesis require the assistance of assembly and quality control factors to ensure the folding of rRNA and proteins into a functional translation machinery. Here we integrate several recent structural snapshots
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::62595344e65fa9f6a2d9c89bc7934e76
https://hdl.handle.net/21.11116/0000-000A-B881-421.11116/0000-000A-B87F-9
https://hdl.handle.net/21.11116/0000-000A-B881-421.11116/0000-000A-B87F-9
Autor:
Nina Bögershausen, Hannah E. Krawczyk, Rami A. Jamra, Sheng‐Jia Lin, Gökhan Yigit, Irina Hüning, Anna M. Polo, Barbara Vona, Kevin Huang, Julia Schmidt, Janine Altmüller, Johannes Luppe, Konrad Platzer, Beate B. Dörgeloh, Andreas Busche, Saskia Biskup, Marisa I. Mendes, Desiree E. C. Smith, Gajja S. Salomons, Arne Zibat, Eva Bültmann, Peter Nürnberg, Malte Spielmann, Johannes R. Lemke, Yun Li, Martin Zenker, Gaurav K. Varshney, Hauke S. Hillen, Christian P. Kratz, Bernd Wollnik
Publikováno v:
Human Mutations
Human mutation, 43(10), 1454-1471. Wiley-Liss Inc.
Human Mutation, 43(10), 1454-1471. Wiley-Liss Inc.
Bögershausen, N, Krawczyk, H E, Jamra, R A, Lin, S-J, Yigit, G K, Hüning, I, Polo, A M, Vona, B, Huang, K, Schmidt, J, Altmüller, J, Luppe, J, Platzer, K, Dörgeloh, B B, Busche, A, Biskup, S, Mendes, M I, Smith, D E C, Salomons, G S, Zibat, A, Bültmann, E, Nürnberg, P, Spielmann, M, Lemke, J R, Li, Y, Zenker, M, Varshney, G K, Hillen, H S, Kratz, C P & Wollnik, B 2022, ' WARS1 and SARS1 : Two tRNA synthetases implicated in autosomal recessive microcephaly ', Human Mutation, vol. 43, no. 10, pp. 1454-1471 . https://doi.org/10.1002/humu.24430
Human mutation, 43(10), 1454-1471. Wiley-Liss Inc.
Human Mutation, 43(10), 1454-1471. Wiley-Liss Inc.
Bögershausen, N, Krawczyk, H E, Jamra, R A, Lin, S-J, Yigit, G K, Hüning, I, Polo, A M, Vona, B, Huang, K, Schmidt, J, Altmüller, J, Luppe, J, Platzer, K, Dörgeloh, B B, Busche, A, Biskup, S, Mendes, M I, Smith, D E C, Salomons, G S, Zibat, A, Bültmann, E, Nürnberg, P, Spielmann, M, Lemke, J R, Li, Y, Zenker, M, Varshney, G K, Hillen, H S, Kratz, C P & Wollnik, B 2022, ' WARS1 and SARS1 : Two tRNA synthetases implicated in autosomal recessive microcephaly ', Human Mutation, vol. 43, no. 10, pp. 1454-1471 . https://doi.org/10.1002/humu.24430
Aminoacylation of tRNA is a key step in protein biosynthesis, carried out by highly specific aminoacyl-tRNA synthetases (ARS). ARS have been implicated in autosomal dominant and autosomal recessive human disorders. Autosomal dominant variants in tryp
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::85935df54049d5375dcb05087f17d26d
https://hdl.handle.net/21.11116/0000-000B-2BDE-C21.11116/0000-000B-2BE0-8
https://hdl.handle.net/21.11116/0000-000B-2BDE-C21.11116/0000-000B-2BE0-8