Výsledky vyhledávání - "Hauke S. Günther"

Taste-immune associative learning amplifies immunopharmacological effects and attenuates disease progression in a rat glioblastoma model

Autor: Susann Hetze, Lennart Barthel, Laura Lückemann, Hauke S. Günther, Clemens Wülfing, Yasmin Salem, Marie Jakobs, Tina Hörbelt-Grünheidt, Jasmin Petschulat, Ivo Bendix, Ulrike Weber-Stadlbauer, Ulrich Sure, Manfred Schedlowski, Martin Hadamitzky

Publikováno v: Brain, Behavior, and Immunity. 106:270-279

Mechanistic target of rapamycin (mTOR)-signaling is one key driver of glioblastoma (GBM), facilitating tumor growth by promoting the shift to an anti-inflammatory, pro-cancerogenic microenvironment. Even though mTOR inhibitors such as rapamycin (RAPA

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ce0cbcb32918566a350769d0e2923c68
https://doi.org/10.1016/j.bbi.2022.09.006

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Data from Glioblastoma Stem–like Cell Lines with Either Maintenance or Loss of High-Level EGFR Amplification, Generated via Modulation of Ligand Concentration

Autor: Katrin Lamszus, Manfred Westphal, Malgorzata Stoupiec, Clemens Wülfing, Sabine Riethdorf, Svenja Zapf, Tobias Martens, Hauke S. Günther, Alexander Schulte

Purpose: Despite the high incidence of epidermal growth factor receptor (EGFR) gene amplification and rearrangement in glioblastomas, no suitable cell line exists that preserves these alterations in vitro and is tumorigenic in immunocompromised mice.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5c83dafdbd64bbcf6d5e94c06a30c2a3
https://doi.org/10.1158/1078-0432.c.6520187

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GFAP and desmin expression in lymphatic tissues leads to difficulties in distinguishing between glial and stromal cells

Autor: Clemens Wülfing, Hauke S. Günther, Nicklas Renevier, Jasmin Oehlmann, Julia Urban, Stephan Henne, Christian Lohr, Desiree Pleizier

Publikováno v: Scientific Reports, Vol 11, Iss 1, Pp 1-14 (2021)
Scientific Reports

Recently, we found many immune cells including antigen presenting cells neurally hard wired in the T-cell zone of most lymphoid organs like amongst others, lymph nodes in rats, mice and humans. Single immune cells were reached by single neurites and

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1b3461254b8a410fa61fa8224f829e59
https://doaj.org/article/a8fce741d001411bbc432ddcdc364c44

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Neural architecture in lymphoid organs: Hard-wired antigen presenting cells and neurite networks in antigen entrance areas

Autor: Clemens Wülfing, Fenja Amrei Schuran, Jasmin Oehlmann, Julia Urban, Hauke S. Günther

Publikováno v: Immunity, Inflammation and Disease. 6:354-370

INTRODUCTION Recently, we found abundant innervation of antigen presenting cells that were reached and enclosed by single neurites. These neurally hard-wired antigen presenting cells (wAPC) could be observed in the T-cell zone of superficial cervical

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::f6cab93774224f110976efa946ae3a30
https://doi.org/10.1002/iid3.223

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Hypoxia and oxygenation induce a metabolic switch between pentose phosphate pathway and glycolysis in glioma stem-like cells

Autor: Manfred Westphal, Annegret Kathagen, Robert Soriano, Markus Glatzel, Katrin Lamszus, Alexander Schulte, Lutz A. Krawinkel, Hauke S. Günther, Mareike Holz, Alain Tissier, Tobias Martens, Heidi S. Phillips, Zora Modrusan, Jakob Matschke, Thomas Sandmann, Gerd Ulrich Balcke, Carsten Kuhl

Publikováno v: Acta Neuropathologica. 126:763-780

Fluctuations in oxygen tension during tissue remodeling impose a major metabolic challenge in human tumors. Stem-like tumor cells in glioblastoma, the most common malignant brain tumor, possess extraordinary metabolic flexibility, enabling them to in

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cb457f8452804ad0898743a60b2a1441
https://doi.org/10.1007/s00401-013-1173-y

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Glioblastoma Stem–like Cell Lines with Either Maintenance or Loss of High-Level EGFR Amplification, Generated via Modulation of Ligand Concentration

Autor: Sabine Riethdorf, Malgorzata Stoupiec, Hauke S. Günther, Clemens Wülfing, Svenja Zapf, Manfred Westphal, Alexander Schulte, Katrin Lamszus, Tobias Martens

Publikováno v: Clinical Cancer Research. 18:1901-1913

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::03a5ff396bfc5bf13ae857a72ac7c87b
https://doi.org/10.1158/1078-0432.ccr-11-3084

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Glioblastoma-derived stem cell-enriched cultures form distinct subgroups according to molecular and phenotypic criteria

Autor: Katrin Lamszus, Nils Ole Schmidt, Manfred Westphal, Robert Soriano, Zora Modrusan, Hildegard Meissner, Heidi S. Phillips, Samir Kharbanda, Dirk Kemming, Hauke S. Günther

Publikováno v: Oncogene. 27:2897-2909

Tumor cells with stem cell-like properties can be cultured from human glioblastomas by using conditions that select for the expansion of neural stem cells. We generated cell lines from glioblastoma specimens with the goal to obtain model systems for

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2ab21499ccb04342bb5d44a5f002d788
https://doi.org/10.1038/sj.onc.1210949

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