Highly diversified shrew hepatitis B viruses corroborate ancient origins and divergent infection patterns of mammalian hepadnaviruses

Autor: Breno Frederico de Carvalho Dominguez Souza, Hauke Niekamp, Debby van Riel, Rainer G. Ulrich, Andreas Geipel, Christian Drosten, Nora Goldmann, Kira Alessandra Alicia Theresa Lowjaga, Ayodeji Olayemi, Andrea Rasche, Ramona Kepper, Dieter Glebe, Felix Lehmann, Victor M. Corman, Thijs Kuiken, Andris Kazaks, Yulia A. Vakulenko, Chantal Akoua-Koffi, Vanessa Schulze, Jan Felix Drexler, Alexander König, Elisabeth Fichet-Calvet, Andres Moreira-Soto, Foday Sahr, Anna-Lena Sander, Alexander N. Lukashev, Joachim Geyer, Rasa Petraityte-Burneikiene, Mathias Schlegel

Publikováno v: Proceedings of the National Academy of Sciences of the United States of Ame, 116(34), 17007-17012. National Academy of Sciences
Proceedings of the National Academy of Sciences

Shrews, insectivorous small mammals, pertain to an ancient mammalian order. We screened 693 European and African shrews for hepatitis B virus (HBV) homologs to elucidate the enigmatic genealogy of HBV. Shrews host HBVs at low prevalence (2.5%) across

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::204620cb1c4a571fa8d76fe8070a49a8
https://doi.org/10.1073/pnas.1908072116

Intracellular accumulation of subviral HBsAg particles and diminished Nrf2 activation in HBV genotype G expressing cells lead to an increased ROI level

Autor: Michael Nuebling, Christoph Sarrazin, Malin Finkernagel, Dieter Glebe, Matthias Hassemer, Gert Carra, Stefan Zeuzem, Kiyoshi Himmelsbach, Sami Akhras, Eberhard Hildt, Michael Chudy, Hauke Niekamp, Kai-Henrik Peiffer

Publikováno v: Journal of hepatology. 62(4)

Background & Aims Hepatitis B virus genotype G (HBV/G) is characterized by a lack of HBeAg secretion and very low HBsAg secretion. This study aimed at (1) comparing HBV genotype G and A2 with respect to morphogenesis and release of HBV-derived partic

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::efb2bfefb7d4ac3145e83d1eea202f36
https://pubmed.ncbi.nlm.nih.gov/25445396