Výsledky vyhledávání - "Haubenreich, Carolin"

Akademický článek

Epigenetic and Transcriptional Shifts in Human Neural Stem Cells after Reprogramming into Induced Pluripotent Stem Cells and Subsequent Redifferentiation.

Autor: Haubenreich, Carolin¹ (AUTHOR) carolin.haubenreich@googlemail.com, Lenz, Michael² (AUTHOR) michael.l.lenz@googlemail.com, Schuppert, Andreas² (AUTHOR) schuppert@combine.rwth-aachen.de, Peitz, Michael^1,3 (AUTHOR) peitz@uni-bonn.de, Koch, Philipp¹ (AUTHOR) philipp.koch@zi-mannheim.de, Zenke, Martin^4,5,6,7 (AUTHOR) martin.zenke@rwth-aachen.de, Brüstle, Oliver¹ (AUTHOR) brustle@uni-bonn.de

Publikováno v: International Journal of Molecular Sciences. Mar2024, Vol. 25 Issue 6, p3214. 15p.

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Additional file 5: of DNA methylation alterations in iPSC- and hESC-derived neurons: potential implications for neurological disease modeling

Autor: Boni, Laura De, Gasparoni, Gilles, Haubenreich, Carolin, Tierling, Sascha, Schmitt, Ina, Peitz, Michael, Koch, Philipp, Walter, Jörn, Wüllner, Ullrich, Brüstle, Oliver

Mean DNA methylation levels of different genomic regions based on the genome-wide 450 K array data [AU ± SD]. AU, arbitrary unit; SD, standard deviation; hES, human embryonic stem cell; NSC, neural stem cell; iPS, induced pluripotent stem cell. (PDF

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::51d82af5b36323334e852ae2d8640dfb

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Additional file 6: of DNA methylation alterations in iPSC- and hESC-derived neurons: potential implications for neurological disease modeling

Autor: Boni, Laura De, Gasparoni, Gilles, Haubenreich, Carolin, Tierling, Sascha, Schmitt, Ina, Peitz, Michael, Koch, Philipp, Walter, Jörn, Wüllner, Ullrich, Brüstle, Oliver

Table of analyzed single genes and primers. (PDF 40 kb)

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Additional file 8: of DNA methylation alterations in iPSC- and hESC-derived neurons: potential implications for neurological disease modeling

Autor: Boni, Laura De, Gasparoni, Gilles, Haubenreich, Carolin, Tierling, Sascha, Schmitt, Ina, Peitz, Michael, Koch, Philipp, Walter, Jörn, Wüllner, Ullrich, Brüstle, Oliver

DNA methylation levels of SNCA intron 1 in pluripotent stem cells (ESC line I3 and I6 (n = 1 each), iPSC line I3 (n = 3), ES- and iPS-NSC (line I3, n = 1 and n = 3, respectively), and ES- and iPS-Neurons (line I3, n = 1 and n = 3, respectively). ESC

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::051226dced5f6da18b337773fe546fd5

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Additional file 1: of DNA methylation alterations in iPSC- and hESC-derived neurons: potential implications for neurological disease modeling

Autor: Boni, Laura De, Gasparoni, Gilles, Haubenreich, Carolin, Tierling, Sascha, Schmitt, Ina, Peitz, Michael, Koch, Philipp, Walter, Jörn, Wüllner, Ullrich, Brüstle, Oliver

A–C Interindividual analysis of DMCG comparing hES-Neurons to each iPSC-derived neuronal clone. D X chromosomal-based DMCG analysis using Fisher’s test. Methylation deltas were calculated as indicated and CpGs above applying a moderate (0.2) or h

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f5c042bb8881a442164d3d3c57831962

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Additional file 7: of DNA methylation alterations in iPSC- and hESC-derived neurons: potential implications for neurological disease modeling

Autor: Boni, Laura De, Gasparoni, Gilles, Haubenreich, Carolin, Tierling, Sascha, Schmitt, Ina, Peitz, Michael, Koch, Philipp, Walter, Jörn, Wüllner, Ullrich, Brüstle, Oliver

Mean DNA methylation levels (%) of single genes (APP, GNAS, MIR886, PMP22, SNCA promoter, SNCA intron 1) of hESC-derived and iPSC-derived NSC and neurons. Analysis is based on individual samples. Data is shown as mean ± SD. (PDF 40 kb)

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Additional file 3: of DNA methylation alterations in iPSC- and hESC-derived neurons: potential implications for neurological disease modeling

Autor: Boni, Laura De, Gasparoni, Gilles, Haubenreich, Carolin, Tierling, Sascha, Schmitt, Ina, Peitz, Michael, Koch, Philipp, Walter, Jörn, Wüllner, Ullrich, Brüstle, Oliver

Comparison of mean Pearson DNA methylation correlation coefficients. Comparisons were made including all ESC- and iPSC-derived NSC and neurons from the human isogenic stem cell system (isogenic hESC- and iPSC-derived NSC and neurons), all samples fro

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Additional file 9: of DNA methylation alterations in iPSC- and hESC-derived neurons: potential implications for neurological disease modeling

Autor: Boni, Laura De, Gasparoni, Gilles, Haubenreich, Carolin, Tierling, Sascha, Schmitt, Ina, Peitz, Michael, Koch, Philipp, Walter, Jörn, Wüllner, Ullrich, Brüstle, Oliver

A–C Immunocytochemical analysis of iPSC generated from hESC-derived NSC staining positive for the pluripotency-associated markers Oct4, Tra-1-60, and Tra-1-81. D–F Upon differentiation, these cells give rise to all three germ layers and express a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1c2927c4389b46a79e148d3b948ef481

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