Zobrazeno 1 - 10
of 49
pro vyhledávání: '"Hattie, Liu"'
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-14 (2023)
Abstract Pharyngeal muscle activity and responsiveness are key pathophysiological traits in human obstructive sleep apnea (OSA) and strong contributors to improvements with pharmacotherapy. The thyrotropin-releasing hormone (TRH) analog taltirelin is
Externí odkaz:
https://doaj.org/article/2a6de399dc3146e7b5508c72b2e38e13
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-25 (2022)
Abstract Successful cholinergic-noradrenergic pharmacotherapy for obstructive sleep apnea (OSA) is thought to be due to effects at the hypoglossal motor nucleus (HMN). Clinical efficacy varies with muscarinic-receptor (MR) subtype affinities. We hypo
Externí odkaz:
https://doaj.org/article/673dde5ff9d74527ae016608e3b3a536
Publikováno v:
Journal of applied physiology (Bethesda, Md. : 1985). 133(5)
One of the major goals for translational sleep science and medicine is to identify viable and tractable pharmacological targets for obstructive sleep apnea and other respiratory disorders of sleep or sedation. In the present preclinical study in rats
Publikováno v:
Sleep
Obstructive sleep apnea (OSA) occurs exclusively during sleep due to reduced tongue motor activity. Withdrawal of excitatory inputs to the hypoglossal motor nucleus (HMN) from wake to sleep contributes to this reduced activity. Several awake–active
Publikováno v:
Sleep
Thyrotropin-releasing hormone (TRH) is produced by the hypothalamus but most brain TRH is located elsewhere where it acts as a neuromodulator. TRH-positive neurons project to the hypoglossal motoneuron pool where TRH receptor RNA shows a high degree
Autor:
Hattie Liu, Richard L. Horner, Jasmin A. Aggarwal, Stuart W. Hughes, Wen-Ying Liu, Gaspard Montandon
Publikováno v:
Scientific Reports
Scientific Reports, Vol 10, Iss 1, Pp 1-20 (2020)
Scientific Reports, Vol 10, Iss 1, Pp 1-20 (2020)
Motoneurons are the final output pathway for the brain’s influence on behavior. Here we identify properties of hypoglossal motor output to the tongue musculature. Tongue motor control is critical to the pathogenesis of obstructive sleep apnea, a co
Autor:
Haiying Wu, Beverley A. Orser, Hattie Liu, Gaspard Montandon, Richard L. Horner, Michael T. Vu
Publikováno v:
Scientific Reports, Vol 7, Iss 1, Pp 1-13 (2017)
Persistent and stable respiratory activity across behavioral states is key to homeostasis. Extrasynaptic δ-subunit containing GABAA receptors (δGABAARs) mediate tonic inhibition and regulate network activity. However, the influence of δGABAARs on
Autor:
Gaspard Montandon, Hattie Liu, Jun Ren, Kevin Wickman, Richard L. Horner, Nicole C. Victoria, John J. Greer
Publikováno v:
Anesthesiology. 124:641-650
Background Drugs acting on μ-opioid receptors (MORs) are widely used as analgesics but present side effects including life-threatening respiratory depression. MORs are G-protein–coupled receptors inhibiting neuronal activity through calcium channe
Autor:
Gaspard, Montandon, Haiying, Wu, Hattie, Liu, Michael T, Vu, Beverley A, Orser, Richard L, Horner
Publikováno v:
Scientific Reports
Persistent and stable respiratory activity across behavioral states is key to homeostasis. Extrasynaptic δ-subunit containing GABAA receptors (δGABAARs) mediate tonic inhibition and regulate network activity. However, the influence of δGABAARs on
Autor:
Richard L. Horner, Jimmy J. Fraigne, Jennifer L. Lapierre, Gaspard Montandon, Hattie Liu, John H. Peever, Zoltan A. Torontali, Garret A. Horton, Matthew B. Snow
Publikováno v:
Scientific Reports
Reduced tongue muscle tone precipitates obstructive sleep apnea (OSA), and activation of the tongue musculature can lessen OSA. The hypoglossal motor nucleus (HMN) innervates the tongue muscles but there is no pharmacological agent currently able to