Dynamic Imaging of LDH Inhibition in Tumors Reveals Rapid In Vivo Metabolic Rewiring and Vulnerability to Combination Therapy.

Autor: Oshima N; Urologic Oncology Branch, Center for Cancer Research, National Cancer Institute, NIH, Bethesda, MD 20892, USA., Ishida R; Urologic Oncology Branch, Center for Cancer Research, National Cancer Institute, NIH, Bethesda, MD 20892, USA., Kishimoto S; Radiation Biology Branch, Center for Cancer Research, National Cancer Institute, NIH, Bethesda, MD 20892, USA., Beebe K; Urologic Oncology Branch, Center for Cancer Research, National Cancer Institute, NIH, Bethesda, MD 20892, USA., Brender JR; Radiation Biology Branch, Center for Cancer Research, National Cancer Institute, NIH, Bethesda, MD 20892, USA., Yamamoto K; Radiation Biology Branch, Center for Cancer Research, National Cancer Institute, NIH, Bethesda, MD 20892, USA., Urban D; Chemical Genomics Center, National Center for Advancing Translational Sciences, National Institutes of Health, Rockville, MD 20850, USA., Rai G; Chemical Genomics Center, National Center for Advancing Translational Sciences, National Institutes of Health, Rockville, MD 20850, USA., Johnson MS; Mitochondrial Medicine Laboratory, Department of Pathology, University of Alabama at Birmingham, Birmingham, AL 35294, USA., Benavides G; Mitochondrial Medicine Laboratory, Department of Pathology, University of Alabama at Birmingham, Birmingham, AL 35294, USA., Squadrito GL; Mitochondrial Medicine Laboratory, Department of Pathology, University of Alabama at Birmingham, Birmingham, AL 35294, USA., Crooks D; Urologic Oncology Branch, Center for Cancer Research, National Cancer Institute, NIH, Bethesda, MD 20892, USA., Jackson J; Urologic Oncology Branch, Center for Cancer Research, National Cancer Institute, NIH, Bethesda, MD 20892, USA., Joshi A; Department of Cell Biology, University of Geneva, 1211 Geneva 4, Switzerland., Mott BT; Chemical Genomics Center, National Center for Advancing Translational Sciences, National Institutes of Health, Rockville, MD 20850, USA., Shrimp JH; Chemical Genomics Center, National Center for Advancing Translational Sciences, National Institutes of Health, Rockville, MD 20850, USA., Moses MA; Urologic Oncology Branch, Center for Cancer Research, National Cancer Institute, NIH, Bethesda, MD 20892, USA., Lee MJ; Developmental Therapeutics Branch, Center for Cancer Research, National Cancer Institute, NIH, Bethesda, MD 20892, USA., Yuno A; Developmental Therapeutics Branch, Center for Cancer Research, National Cancer Institute, NIH, Bethesda, MD 20892, USA., Lee TD; Chemical Genomics Center, National Center for Advancing Translational Sciences, National Institutes of Health, Rockville, MD 20850, USA., Hu X; Chemical Genomics Center, National Center for Advancing Translational Sciences, National Institutes of Health, Rockville, MD 20850, USA., Anderson T; University of New Mexico Health Sciences Center, Albuquerque, NM 87131, USA., Kusewitt D; University of New Mexico Health Sciences Center, Albuquerque, NM 87131, USA., Hathaway HH; University of New Mexico Health Sciences Center, Albuquerque, NM 87131, USA., Jadhav A; Chemical Genomics Center, National Center for Advancing Translational Sciences, National Institutes of Health, Rockville, MD 20850, USA., Picard D; Department of Cell Biology, University of Geneva, 1211 Geneva 4, Switzerland., Trepel JB; Developmental Therapeutics Branch, Center for Cancer Research, National Cancer Institute, NIH, Bethesda, MD 20892, USA., Mitchell JB; Radiation Biology Branch, Center for Cancer Research, National Cancer Institute, NIH, Bethesda, MD 20892, USA., Stott GM; Leidos Biomedical, Frederick National Laboratory for Cancer Research, Frederick, MD 24060, USA., Moore W; Leidos Biomedical, Frederick National Laboratory for Cancer Research, Frederick, MD 24060, USA., Simeonov A; Chemical Genomics Center, National Center for Advancing Translational Sciences, National Institutes of Health, Rockville, MD 20850, USA., Sklar LA; University of New Mexico Health Sciences Center, Albuquerque, NM 87131, USA., Norenberg JP; University of New Mexico Health Sciences Center, Albuquerque, NM 87131, USA., Linehan WM; Urologic Oncology Branch, Center for Cancer Research, National Cancer Institute, NIH, Bethesda, MD 20892, USA., Maloney DJ; Chemical Genomics Center, National Center for Advancing Translational Sciences, National Institutes of Health, Rockville, MD 20850, USA., Dang CV; Ludwig Institute for Cancer Research, New York, NY 10017, USA; The Wistar Institute, Philadelphia, PA 19104, USA., Waterson AG; Department of Chemistry, Vanderbilt University, Nashville, TN 37240, USA., Hall M; Chemical Genomics Center, National Center for Advancing Translational Sciences, National Institutes of Health, Rockville, MD 20850, USA., Darley-Usmar VM; Mitochondrial Medicine Laboratory, Department of Pathology, University of Alabama at Birmingham, Birmingham, AL 35294, USA., Krishna MC; Radiation Biology Branch, Center for Cancer Research, National Cancer Institute, NIH, Bethesda, MD 20892, USA., Neckers LM; Urologic Oncology Branch, Center for Cancer Research, National Cancer Institute, NIH, Bethesda, MD 20892, USA. Electronic address: neckersl@mail.nih.gov.

Publikováno v: Cell reports [Cell Rep] 2020 Feb 11; Vol. 30 (6), pp. 1798-1810.e4.