Cytokine response in cerebrospinal fluid of meningitis patients and outcome associated with pneumococcal serotype

Autor: M��ller, Annelies, Schramm, Diana B, Kleynhans, Jackie, de Gouveia, Linda, Meiring, Susan, Ramette, Alban, von Gottberg, Anne, Hathaway, Lucy Jane

Publikováno v: Müller, Annelies; Schramm, Diana B; Kleynhans, Jackie; de Gouveia, Linda; Meiring, Susan; Ramette, Alban; von Gottberg, Anne; Hathaway, Lucy Jane (2021). Cytokine response in cerebrospinal fluid of meningitis patients and outcome associated with pneumococcal serotype. Scientific reports, 11(1), p. 19920. Springer Nature 10.1038/s41598-021-99190-3
Scientific Reports
Scientific Reports, Vol 11, Iss 1, Pp 1-9 (2021)

Streptococcus pneumoniae causes life-threatening meningitis. Its capsular polysaccharide determines the serotype and influences disease severity but the mechanism is largely unknown. Due to evidence of elevated cytokines levels in the meningeal infla

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https://boris.unibe.ch/159979/1/s41598-021-99190-3.pdf

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A low affinity penicillin-binding protein 2x is required for heteroresistance in Streptococcus pneumoniae

Autor: Hilty, Markus, Engel, Hans Jürg, Mika, Moana, Mühlemann, Kathrin, Denapaite, Dalia, Hakenbeck, Regine, Hathaway, Lucy Jane, Heller, Manfred

Heteroresistance to penicillin in Streptococcus pneumoniae is the ability of subpopulations to grow at a higher antibiotic concentration than expected from the minimal inhibitory concentration (MIC). This may render conventional resistance testing un

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Streptococcus pneumoniae capsule determines disease severity in experimental pneumococcal meningitis

Autor: Leib, Stephen, Valente, Luca Gabriele, Täuber, Martin G., Grandgirard, Denis, Hathaway, Lucy Jane

Streptococcus pneumoniaebacteria can be characterized into over 90 serotypes according to the composition of their polysaccharide capsules. Some serotypes are common in nasopharyngeal carriage whereas others are associated with invasive disease, but

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The Pneumococcal Polysaccharide Capsule and Pneumolysin Differentially Affect CXCL8 and IL-6 Release from Cells of the Upper and Lower Respiratory Tract

Autor: Küng, Eliane, Coward, William R., Neill, Daniel R., Malak, Hesham A., Mühlemann, Kathrin, Kadioglu, Aras, Hilty, Markus, Hathaway, Lucy Jane

The polysaccharide capsule and pneumolysin toxin are major virulence factors of the human bacterial pathogen Streptococcus pneumoniae. Colonization of the nasopharynx is asymptomatic but invasion of the lungs can result in invasive pneumonia. Here we

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::2ab1a8ec5240b2aa6c0c97818fc3bb0c