Electrophysiological Characterization of Inducible Pluripotent Stem Cell–Derived Human β-Like Cells and an SLC30A8 Disease Model.

Autor: Jaffredo, Manon, Krentz, Nicole A.J., Champon, Benoite, Duff, Claire E., Nawaz, Sameena, Beer, Nicola, Honore, Christian, Clark, Anne, Rorsman, Patrik, Lang, Jochen, Gloyn, Anna L., Raoux, Matthieu, Hastoy, Benoit

Publikováno v: Diabetes; Aug2024, Vol. 73 Issue 8, p1255-1265, 11p

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Type 2 Diabetes risk alleles in Peptidyl-glycine Alpha-amidating Monooxygenase influence GLP-1 levels and response to GLP-1 Receptor Agonists

Autor: Umapathysivam, Mahesh M, Araldi, Elisa, Hastoy, Benoit, Dawed, Adem Y, Vatandaslar, Hasan, Sengupta, Shahana, Kaufmann, Adrian, Thomsen, Søren, Hartmann, Bolette, Jonsson, Anna E, Kabakci, Hasan, Thaman, Swaraj, Grarup, Niels, Have, Christian T, Færch, Kristine, Gjesing, Anette P, Nawaz, Sameena, Cheeseman, Jane, Neville, Matthew J, Pedersen, Oluf, Walker, Mark, Jennison, Christopher, Hattersley, Andrew T, Hansen, Torben, Karpe, Fredrik, Holst, Jens J, Jones, Angus G, Ristow, Michael, McCarthy, Mark I, Pearson, Ewan R, Stoffel, Markus, Gloyn, Anna L

Publikováno v: Umapathysivam, M M, Araldi, E, Hastoy, B, Dawed, A Y, Vatandaslar, H, Sengupta, S, Kaufmann, A, Thomsen, S, Hartmann, B, Jonsson, A E, Kabakci, H, Thaman, S, Grarup, N, Have, C T, Færch, K, Gjesing, A P, Nawaz, S, Cheeseman, J, Neville, M J, Pedersen, O, Walker, M, Jennison, C, Hattersley, A T, Hansen, T, Karpe, F, Holst, J J, Jones, A G, Ristow, M, McCarthy, M I, Pearson, E R, Stoffel, M & Gloyn, A L 2023 ' Type 2 Diabetes risk alleles in Peptidyl-glycine Alpha-amidating Monooxygenase influence GLP-1 levels and response to GLP-1 Receptor Agonists ' medRxiv . https://doi.org/10.1101/2023.04.07.23288197

UNLABELLED: Patients with type 2 diabetes vary in their response to currently available therapeutic agents (including GLP-1 receptor agonists) leading to suboptimal glycemic control and increased risk of complications. We show that human carriers of

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=od______2751::f2319081696b09ed2050368514ec78fd
https://curis.ku.dk/ws/files/350979933/2023.04.07.23288197v1.full.pdf

Loss of tetraspanin‐7 expression reduces pancreatic β‐cell exocytosis Ca²⁺ sensitivity but has limited effect on systemic metabolism.

Autor: McLaughlin, Kerry, Acreman, Samuel, Nawaz, Sameena, Cutteridge, Joseph, Clark, Anne, Knudsen, Jakob G., Denwood, Geoffrey, Spigelman, Aliya F., Manning Fox, Jocelyn E., Singh, Sumeet Pal, MacDonald, Patrick E., Hastoy, Benoit, Zhang, Quan

Publikováno v: Diabetic Medicine; Dec2022, Vol. 39 Issue 12, p1-13, 13p

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