B lymphocyte-deficiency in mice causes vascular dysfunction by inducing neutrophilia

Autor: Xia, N., Hasselwander, S., Reifenberg, G., Habermeier, A., Closs, E., Mimmler, M., Jung, R., Karbach, S., Lagrange, J., Wenzel, P., Daiber, A., Münzel, T., Hövelmeyer, N., Waisman, A., Li, H.

Publikováno v: In Atherosclerosis August 2022 355

B lymphocyte-deficiency in mice promotes venous thrombosis.

Autor: Hasselwander S; Department of Pharmacology, Johannes Gutenberg University Medical Center, Langenbeckstr. 1, 55131 Mainz, Germany., Xia N; Department of Pharmacology, Johannes Gutenberg University Medical Center, Langenbeckstr. 1, 55131 Mainz, Germany., Mimmler M; Department of Pharmacology, Johannes Gutenberg University Medical Center, Langenbeckstr. 1, 55131 Mainz, Germany.; Center for Thrombosis and Hemostasis, Johannes Gutenberg University Medical Center, Langenbeckstr. 1, 55131 Mainz, Germany., Ascher S; Center for Thrombosis and Hemostasis, Johannes Gutenberg University Medical Center, Langenbeckstr. 1, 55131 Mainz, Germany., Knopp T; Center for Thrombosis and Hemostasis, Johannes Gutenberg University Medical Center, Langenbeckstr. 1, 55131 Mainz, Germany., Reifenberg G; Department of Pharmacology, Johannes Gutenberg University Medical Center, Langenbeckstr. 1, 55131 Mainz, Germany., Karbach S; Center for Thrombosis and Hemostasis, Johannes Gutenberg University Medical Center, Langenbeckstr. 1, 55131 Mainz, Germany.; Department of Cardiology, Cardiology 1, Johannes Gutenberg University Medical Center, 55131 Mainz, Germany.; German Center for Cardiovascular Research (DZHK), Partner Site Rhein-Main, Johannes Gutenberg University Medical Center, Langenbeckstr. 1, 55131 Mainz, Germany., Ruf W; Center for Thrombosis and Hemostasis, Johannes Gutenberg University Medical Center, Langenbeckstr. 1, 55131 Mainz, Germany.; German Center for Cardiovascular Research (DZHK), Partner Site Rhein-Main, Johannes Gutenberg University Medical Center, Langenbeckstr. 1, 55131 Mainz, Germany., Reinhardt C; Center for Thrombosis and Hemostasis, Johannes Gutenberg University Medical Center, Langenbeckstr. 1, 55131 Mainz, Germany.; German Center for Cardiovascular Research (DZHK), Partner Site Rhein-Main, Johannes Gutenberg University Medical Center, Langenbeckstr. 1, 55131 Mainz, Germany., Li H; Department of Pharmacology, Johannes Gutenberg University Medical Center, Langenbeckstr. 1, 55131 Mainz, Germany.; German Center for Cardiovascular Research (DZHK), Partner Site Rhein-Main, Johannes Gutenberg University Medical Center, Langenbeckstr. 1, 55131 Mainz, Germany.

Publikováno v: Heliyon [Heliyon] 2022 Nov 17; Vol. 8 (11), pp. e11740. Date of Electronic Publication: 2022 Nov 17 (Print Publication: 2022).

Heme oxygenase 1 protects human colonocytes against ROS formation, oxidative DNA damage and cytotoxicity induced by heme iron, but not inorganic iron.

Autor: Seiwert N; Department of Toxicology, University Medical Center, Mainz, Germany.; Rudolf Buchheim Institute of Pharmacology, Justus Liebig University Giessen, Giessen, Germany.; Division of Food Chemistry and Toxicology, Department of Chemistry, Technical University of Kaiserslautern, Kaiserslautern, Germany., Wecklein S; Department of Toxicology, University Medical Center, Mainz, Germany., Demuth P; Division of Food Chemistry and Toxicology, Department of Chemistry, Technical University of Kaiserslautern, Kaiserslautern, Germany., Hasselwander S; Department of Toxicology, University Medical Center, Mainz, Germany.; Department of Pharmacology, University Medical Center, Mainz, Germany., Kemper TA; Department of Food Chemistry, Institute of Nutritional Science, University of Potsdam, Nuthetal, Germany., Schwerdtle T; Department of Food Chemistry, Institute of Nutritional Science, University of Potsdam, Nuthetal, Germany.; TraceAge - DFG Research Unit on Interactions of Essential Trace Elements in Healthy and Diseased Elderly (FOR 2558), Berlin-Potsdam-Jena, Germany., Brunner T; Biochemical Pharmacology, Department of Biology, University of Konstanz, Konstanz, Germany., Fahrer J; Department of Toxicology, University Medical Center, Mainz, Germany. fahrer@chemie.uni-kl.de.; Rudolf Buchheim Institute of Pharmacology, Justus Liebig University Giessen, Giessen, Germany. fahrer@chemie.uni-kl.de.; Division of Food Chemistry and Toxicology, Department of Chemistry, Technical University of Kaiserslautern, Kaiserslautern, Germany. fahrer@chemie.uni-kl.de.

Publikováno v: Cell death & disease [Cell Death Dis] 2020 Sep 23; Vol. 11 (9), pp. 787. Date of Electronic Publication: 2020 Sep 23.

B Lymphocyte-Deficiency in Mice Causes Vascular Dysfunction by Inducing Neutrophilia.

Autor: Xia N; Department of Pharmacology, Johannes Gutenberg University Medical Center, 55131 Mainz, Germany., Hasselwander S; Department of Pharmacology, Johannes Gutenberg University Medical Center, 55131 Mainz, Germany., Reifenberg G; Department of Pharmacology, Johannes Gutenberg University Medical Center, 55131 Mainz, Germany., Habermeier A; Department of Pharmacology, Johannes Gutenberg University Medical Center, 55131 Mainz, Germany., Closs EI; Department of Pharmacology, Johannes Gutenberg University Medical Center, 55131 Mainz, Germany., Mimmler M; Department of Pharmacology, Johannes Gutenberg University Medical Center, 55131 Mainz, Germany., Jung R; Institute for Molecular Medicine, Johannes Gutenberg University Medical Center, 55131 Mainz, Germany.; Center for Thrombosis and Hemostasis, Johannes Gutenberg University Medical Center, 55131 Mainz, Germany., Karbach S; Center for Thrombosis and Hemostasis, Johannes Gutenberg University Medical Center, 55131 Mainz, Germany.; Department of Cardiology, Cardiology 1, Johannes Gutenberg University Medical Center, 55131 Mainz, Germany., Lagrange J; Center for Thrombosis and Hemostasis, Johannes Gutenberg University Medical Center, 55131 Mainz, Germany.; Department of Cardiology, Cardiology 1, Johannes Gutenberg University Medical Center, 55131 Mainz, Germany., Wenzel P; Center for Thrombosis and Hemostasis, Johannes Gutenberg University Medical Center, 55131 Mainz, Germany.; Department of Cardiology, Cardiology 1, Johannes Gutenberg University Medical Center, 55131 Mainz, Germany.; German Center for Cardiovascular Research (DZHK), Partner Site Rhine-Main, 55131 Mainz, Germany., Daiber A; Department of Cardiology, Cardiology 1, Johannes Gutenberg University Medical Center, 55131 Mainz, Germany.; German Center for Cardiovascular Research (DZHK), Partner Site Rhine-Main, 55131 Mainz, Germany., Münzel T; Department of Cardiology, Cardiology 1, Johannes Gutenberg University Medical Center, 55131 Mainz, Germany.; German Center for Cardiovascular Research (DZHK), Partner Site Rhine-Main, 55131 Mainz, Germany., Hövelmeyer N; Institute for Molecular Medicine, Johannes Gutenberg University Medical Center, 55131 Mainz, Germany.; Research Center for Immunotherapy (FZI), Johannes Gutenberg University Medical Center, 55131 Mainz, Germany., Waisman A; Institute for Molecular Medicine, Johannes Gutenberg University Medical Center, 55131 Mainz, Germany.; Research Center for Immunotherapy (FZI), Johannes Gutenberg University Medical Center, 55131 Mainz, Germany., Li H; Department of Pharmacology, Johannes Gutenberg University Medical Center, 55131 Mainz, Germany.; German Center for Cardiovascular Research (DZHK), Partner Site Rhine-Main, 55131 Mainz, Germany.

Publikováno v: Biomedicines [Biomedicines] 2021 Nov 14; Vol. 9 (11). Date of Electronic Publication: 2021 Nov 14.

Targeting PARP-1 and DNA Damage Response Defects in Colorectal Cancer Chemotherapy with Established and Novel PARP Inhibitors.

Autor: Demuth, Philipp¹ (AUTHOR) pdemuth@rptu.de, Thibol, Lea¹ (AUTHOR) thibol@rptu.de, Lemsch, Anna¹ (AUTHOR) anna.lemsch@gmx.de, Potlitz, Felix² (AUTHOR) felix.potlitz@gmail.com, Schulig, Lukas² (AUTHOR) lukas.schulig@uni-greifswald.de, Grathwol, Christoph³ (AUTHOR) christoph.grathwol@kit.edu, Manolikakes, Georg⁴ (AUTHOR) manolikakes@chemie.uni-kl.de, Schade, Dennis⁵ (AUTHOR) schade@pharmazie.uni-kiel.de, Roukos, Vassilis⁶ (AUTHOR) v.roukos@imb-mainz.de, Link, Andreas² (AUTHOR) link@uni-greifswald.de, Fahrer, Jörg¹ (AUTHOR) fahrer@chemie.uni-kl.de

Publikováno v: Cancers. Oct2024, Vol. 16 Issue 20, p3441. 25p.