Sustained immune activation and impaired epithelial barrier integrity in the ectocervix of women with chronic HIV infection.

Autor: Franzén Boger, Mathias¹ (AUTHOR) Mathias.franzen.boger@ki.se, Hasselrot, Tyra¹ (AUTHOR), Kaldhusdal, Vilde¹ (AUTHOR), Miranda, Gisele H. B.^2,3 (AUTHOR), Czarnewski, Paulo⁴ (AUTHOR), Edfeldt, Gabriella¹ (AUTHOR), Bradley, Frideborg¹ (AUTHOR), Rexaj, Genta¹ (AUTHOR), Lajoie, Julie⁵ (AUTHOR), Omollo, Kenneth⁶ (AUTHOR), Kimani, Joshua^5,6,7 (AUTHOR), Fowke, Keith R.^5,6,7,8 (AUTHOR), Broliden, Kristina¹ (AUTHOR), Tjernlund, Annelie¹ (AUTHOR)

Publikováno v: PLoS Pathogens. 11/19/2024, Vol. 20 Issue 11, p1-29. 29p.

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A topical rectal douche product containing Q-Griffithsin does not disrupt the epithelial border or alter CD4 ⁺ cell distribution in the human rectal mucosa.

Autor: Franzén Boger M; Division of Infectious Diseases, Department of Medicine Solna, Center for Molecular Medicine, Karolinska University Hospital, Karolinska Institutet, Bioclinicum J7:20, 171 64, Solna, Sweden. mathias.franzen.boger@ki.se., Benhach N; Division of Infectious Diseases, Department of Medicine Solna, Center for Molecular Medicine, Karolinska University Hospital, Karolinska Institutet, Bioclinicum J7:20, 171 64, Solna, Sweden., Hasselrot T; Division of Infectious Diseases, Department of Medicine Solna, Center for Molecular Medicine, Karolinska University Hospital, Karolinska Institutet, Bioclinicum J7:20, 171 64, Solna, Sweden., Brand RM; Magee Womens Research Institute, Pittsburgh, PA, USA.; Department of Medicine, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA., Rohan LC; Magee Womens Research Institute, Pittsburgh, PA, USA.; Department of Pharmaceutical Sciences, University of Pittsburgh School of Pharmacy, Pittsburgh, PA, USA., Wang L; Magee Womens Research Institute, Pittsburgh, PA, USA.; Department of Pharmaceutical Sciences, University of Pittsburgh School of Pharmacy, Pittsburgh, PA, USA., McGowan I; Magee Womens Research Institute, Pittsburgh, PA, USA.; Department of Medicine, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.; Orion Biotechnology, Ottawa, Canada., Edick S; Department of Medicine, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA., Ho K; Department of Medicine, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA., Meyn L; Magee Womens Research Institute, Pittsburgh, PA, USA., Matoba N; Center for Predictive Medicine for Biodefense and Emerging Infectious Diseases, University of Louisville, Louisville, KY, USA.; UofL Health-Brown Cancer Center, University of Louisville, Louisville, KY, USA.; Department of Pharmacology and Toxicology, School of Medicine, University of Louisville, Louisville, KY, USA., Palmer KE; Center for Predictive Medicine for Biodefense and Emerging Infectious Diseases, University of Louisville, Louisville, KY, USA.; UofL Health-Brown Cancer Center, University of Louisville, Louisville, KY, USA.; Department of Pharmacology and Toxicology, School of Medicine, University of Louisville, Louisville, KY, USA., Broliden K; Division of Infectious Diseases, Department of Medicine Solna, Center for Molecular Medicine, Karolinska University Hospital, Karolinska Institutet, Bioclinicum J7:20, 171 64, Solna, Sweden., Tjernlund A; Division of Infectious Diseases, Department of Medicine Solna, Center for Molecular Medicine, Karolinska University Hospital, Karolinska Institutet, Bioclinicum J7:20, 171 64, Solna, Sweden.

Publikováno v: Scientific reports [Sci Rep] 2023 May 09; Vol. 13 (1), pp. 7547. Date of Electronic Publication: 2023 May 09.