Zobrazeno 1 - 10
of 13
pro vyhledávání: '"Hasse Kromann"'
Autor:
Thomas Boesen, Anders Hallberg, Hans-Erik Claesson, Benjamin Pelcman, Wesley Schaal, Christian Krog-Jensen, Pontus Forsell, Mats Larhed, Hasse Kromann, Kristofer Olofsson, Andrei Sanin, Peter M. Nilsson
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 25:3017-3023
High-throughput screening was used to find selective inhibitors of human 15-lipoxygenase-1 (15-LOX-1). One hit, a 1-benzoyl substituted pyrazole-3-carboxanilide (1a), was used as a starting point in a program to develop potent and selective 15-LOX-1
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::21aca60170fc4bc27389efef90bf1013
https://doi.org/10.1016/j.bmcl.2015.05.007
https://doi.org/10.1016/j.bmcl.2015.05.007
Autor:
Anders Hallberg, Peter M. Nilsson, Kiyo No, Mats Larhed, Thomas Boesen, Andrei Sanin, Wesley Schaal, Pontus Forsell, Stine B. Vogensen, Thomas Groth, Sara Öhrman, Hasse Kromann, Hans-Erik Claesson, Benjamin Pelcman, Christian Krog-Jensen
Publikováno v:
Bioorganicmedicinal chemistry letters. 25(15)
Investigation of 1N-substituted pyrazole-3-carboxanilides as 15-lipoxygenase-1 (15-LOX-1) inhibitors demonstrated that the 1N-substituent was not essential for activity or selectivity. Additional halogen substituents on the pyrazole ring, however, in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0312fd82362c6cfe50e25127acd222cf
https://pubmed.ncbi.nlm.nih.gov/26037322
https://pubmed.ncbi.nlm.nih.gov/26037322
Publikováno v:
Bioorganic & Medicinal Chemistry. 12:3047-3054
Hydroxy chalcones, for example, Licochalcone A, has for several years been known to be antibacterial. The low aqueous solubility and the medium antibacterial potency have limited the usefulness of the compounds. We describe the bioisosteric replaceme
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bcb0c48d7cbc23eb02c62a07252d55da
https://doi.org/10.1016/j.bmc.2004.03.071
https://doi.org/10.1016/j.bmc.2004.03.071
Autor:
Jakob Felding, Finn Junager, Peter Uhlmann, Povl Krogsgaard-Larsen, Tine B. Stensbøl, Per Vedsø, Mikael Begtrup, Hasse Kromann, Sandrine Morel, Birgitte Langer Eriksen, Hans Bräuner-Osborne, Mette B. Hermit, Ulf Madsen, Jeremy R. Greenwood
Publikováno v:
Journal of Medicinal Chemistry. 45:19-31
A number of 1-hydroxyazole derivatives were synthesized as bioisosteres of (S)-glutamic acid (Glu) and as analogues of the AMPA receptor agonist (R,S)-2-amino-3-(3-hydroxy-5-methyl-4-isoxazolyl)propionic acid (AMPA, 3b). All compounds were subjected
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3ff8aace4f466a824f9dd8ca09604954
https://doi.org/10.1021/jm010303j
https://doi.org/10.1021/jm010303j
Publikováno v:
Tetrahedron. 57:2195-2201
The coupling reactions were performed using 3-ethoxy-4-iodo-5-methylisoxazole (4) as the key intermediate. Coupling of 4 under Suzuki–Miyaura or Stille conditions using Pd(PPh3)2Cl2 and arylboronic acids or aryltin analogues, respectively, gave 4-a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::37bd780db5bce887bfb49117c4e55545
https://doi.org/10.1016/s0040-4020(01)00052-7
https://doi.org/10.1016/s0040-4020(01)00052-7
Publikováno v:
FEBS Letters. 439:127-132
Thapsigargin is a highly potent and selective inhibitor of sarco-endoplasmic reticulum (SERCA) family of Ca2+-ATPases and a useful tool in research concerning the function of intracellular Ca2+ stores. We describe here a novel fluorescent derivative
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::70f349193037471fd39ee90f1f47a11a
https://doi.org/10.1016/s0014-5793(98)01352-0
https://doi.org/10.1016/s0014-5793(98)01352-0
Publikováno v:
ChemInform. 32
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9f1c38d98c8ed837c3ac84987fdade1e
https://doi.org/10.1002/chin.200131127
https://doi.org/10.1002/chin.200131127
Publikováno v:
Bioorganicmedicinal chemistry letters. 15(21)
Chalcones can exist as Z- or E-isomers and it is generally anticipated that both isomers are equipotent. In order to determine the active isomer of anti-plasmodial chalcones a series of analogues locked in the Z- or the E-form were prepared and evalu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7c25e36653a7ca2de71224e2a2848c89
https://pubmed.ncbi.nlm.nih.gov/16153842
https://pubmed.ncbi.nlm.nih.gov/16153842
Publikováno v:
Journal of medicinal chemistry. 48(7)
This paper describes how the introduction of "cationic" aliphatic amino groups in the chalcone scaffold results in potent antibacterial compounds. It is shown that the most favorable position for the aliphatic amino group is the 2-position of the B-r
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::549ff9e75ea72491c6f4f8f81c2a7726
https://pubmed.ncbi.nlm.nih.gov/15801857
https://pubmed.ncbi.nlm.nih.gov/15801857
Autor:
Anne J. Andersen, Povl Krogsgaard-Larsen, Jerzy W. Jaroszewski, Sonata Krikstolaityte, Kristian Strømgaard, Kim Andersen, Jan Egebjerg, Hasse Kromann
Publikováno v:
Journal of medicinal chemistry. 45(26)
The wasp toxin philanthotoxin-433 (PhTX-433) is a nonselective and noncompetitive antagonist of ionotropic receptors, such as ionotropic glutamate receptors and nicotinic acetylcholine receptors. Polyamine toxins are extensively used for the characte
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::caf2a99e38ee403a997c0ebf5e327244
https://pubmed.ncbi.nlm.nih.gov/12477358
https://pubmed.ncbi.nlm.nih.gov/12477358