A shape-shifting redox foldase contributes to Proteus mirabilis copper resistance

Autor: Emily J. Furlong, Alvin W. Lo, Fabian Kurth, Lakshmanane Premkumar, Makrina Totsika, Maud E. S. Achard, Maria A. Halili, Begoña Heras, Andrew E. Whitten, Hassanul G. Choudhury, Mark A. Schembri, Jennifer L. Martin

Publikováno v: Nature Communications, Vol 8, Iss 1, Pp 1-10 (2017)

Bacterial disulfide isomerases shuffle incorrect disulfide bonds. Here, the authors structurally characterize the disulfide isomerase ScsC fromProteus mirabilisand identify a functionally important shape-shifting motif that allows ScsC to adopt a div

Externí odkaz: https://doaj.org/article/8f04e6bca0c44df1aae8cb752f2ba122

Heterologous Expression and Biochemical Characterization of the Human Zinc Transporter 1 (ZnT1) and Its Soluble C-Terminal Domain

Autor: Russell J. Jarrott, Jennifer L. Martin, Hassanul G. Choudhury, David A. Drew, Andrew E. Whitten, Camila A. Cotrim

Publikováno v: Frontiers in Chemistry
Frontiers in Chemistry, Vol 9 (2021)

Human zinc transporter 1 (hZnT1) belongs to the cation diffusion facilitator (CDF) family. It plays a major role in transporting zinc (Zn2+) from the cytoplasm across the plasma membrane and into the extracellular space thereby protecting cells from

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::844547700b31123d705ea9c1b9601691
https://pubmed.ncbi.nlm.nih.gov/33996761

Author Correction: A shape-shifting redox foldase contributes to Proteus mirabilis copper resistance

Autor: Lakshmanane Premkumar, Begoña Heras, Alvin W. Lo, F. Kurth, Emily Furlong, Mark A. Schembri, Maria A. Halili, Hassanul G. Choudhury, Andrew E. Whitten, Maud E. S. Achard, Jennifer L. Martin, Makrina Totsika

Publikováno v: Nature Communications
Nature Communications, Vol 10, Iss 1, Pp 1-2 (2019)

Copper resistance is a key virulence trait of the uropathogen Proteus mirabilis. Here we show that P. mirabilis ScsC (PmScsC) contributes to this defence mechanism by enabling swarming in the presence of copper. We also demonstrate that PmScsC is a t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fc9513b4108d40503c96267ecf218c66
http://europepmc.org/articles/PMC6397206

Disulfide isomerase activity of the dynamic, trimeric

Autor: Emily J, Furlong, Hassanul G, Choudhury, Fabian, Kurth, Anthony P, Duff, Andrew E, Whitten, Jennifer L, Martin

Publikováno v: The Journal of biological chemistry. 293(16)

Correct disulfide bond formation is essential for proper folding of many proteins, including bacterial virulence factors. The suppressor of copper sensitivity (Scs) proteins have roles in dithiol/disulfide interchange and the bacterial response to co

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::5a33ba7013e07a0ce2c65687c2010925
https://pubmed.ncbi.nlm.nih.gov/29491145

Structural and functional basis for lipid synergy on the activity of the antibacterial peptide ABC transporter McjD

Autor: Danny Axford, Konstantinos Beis, Séverine Zirah, Hassanul G. Choudhury, Rohanah Hussain, Carol V. Robinson, Shahid Mehmood, Sylvie Rebuffat, Patrick Becker, D. Peter Tieleman, Valentina Corradi

Publikováno v: Journal of Biological Chemistry
Journal of Biological Chemistry, American Society for Biochemistry and Molecular Biology, 2016, 291 (41), pp.21656-21668. ⟨10.1074/jbc.M116.732107⟩

The lipid bilayer is a dynamic environment that consists of a mixture of lipids with different properties that regulate the function of membrane proteins; these lipids are either annular, masking the protein hydrophobic surface, or specific lipids, e

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9107794eab207933dfe34d0163c76613
http://ora.ox.ac.uk/objects/uuid: