Zobrazeno 1 - 10
of 26
pro vyhledávání: '"Hassan M. Eisa"'
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-17 (2024)
Abstract Two new series of oxadiazole and pyrazoline derivatives were designed and synthesized as promising EGFR-TK inhibitors. The in vitro antiproliferative activity was studied against three human cancer cell lines; HCT116, HepG-2 and MCF7 using M
Externí odkaz:
https://doaj.org/article/6284f0a0aa3541e7984ea263ae2507cf
Publikováno v:
ACS Omega, Vol 7, Iss 49, Pp 45455-45468 (2022)
Externí odkaz:
https://doaj.org/article/1f0ac9d7bf7941d4a51722cc044494e9
Publikováno v:
Bioorganic chemistry. 129
A new series of triclosan (TCL)-mimicking diaryl ether derivatives 7-25 were synthesized and evaluated as inhibitors of enoyl acyl carrier protein reductase InhA enzyme. In addition, these derivatives were screened as inhibitors of drug-susceptible (
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3761d2b0da4dbc658892a00c4b0dec8d
https://pubmed.ncbi.nlm.nih.gov/36126606
https://pubmed.ncbi.nlm.nih.gov/36126606
Autor:
Basem Mansour, Amira Taman, Waleed A. Bayoumi, Serry A. A. El Bialy, Mohammad A. Elmorsy, Hassan M. Eisa, Fouad El-Shehabi
Publikováno v:
Biophysical chemistry. 278
Schistosomiasis is one of the neglected diseases causing considerable morbidity and mortality throughout the world. Microtubules with its main component, tubulin play a vital role in helminthes including schistosomes. Benzimidazoles represent potenti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::29f9c4dee99eef704e13d251bff29d94
https://pubmed.ncbi.nlm.nih.gov/34482215
https://pubmed.ncbi.nlm.nih.gov/34482215
Publikováno v:
Bioorg Med Chem
New series of benzimidazole ring core conjugated with either dithiocarbamate or thiopropyl linkers, hybridized with different secondary amines were synthesized; 5–15 and 22–31; respectively. The new compounds were characterized by different spect
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::74c4281cb8fbaefe317e506fbb2f0d8c
https://doi.org/10.1016/j.bmc.2020.115495
https://doi.org/10.1016/j.bmc.2020.115495
Publikováno v:
Heterocyclic Communications. 21:367-375
New pyrazoles have been synthesized and evaluated as breast cancer cell growth inhibitors. Condensation of the substituted pyrazole-4-carbaldehyde 1 with acetophenone and chloroacetophenone afforded α, β-unsaturated ketones 2 and 3, respectively. C
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::da09003b48a7177602bba260d0ca40df
https://doi.org/10.1515/hc-2015-0156
https://doi.org/10.1515/hc-2015-0156
Publikováno v:
Medicinal Chemistry Research. 21:2368-2378
A series of novel [1,2,4]triazolo[4,3-a]quinoxaline derivatives and their isosteres, pyrimido-quinoxaline, were synthesized as potential antiviral and antimicrobial agents. The new compounds were synthesized via aromatic nucleophilic substitution of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b3db049d2187a52574dffa329c375204
https://doi.org/10.1007/s00044-011-9753-7
https://doi.org/10.1007/s00044-011-9753-7
Publikováno v:
Medicinal Chemistry Research. 21:703-710
A novel series of 1,3,5-triazine analogs was successfully synthesized through conjugation with benzimidazole or 1,2,4-triazole derivatives via a methylenethio linker. The new analogs were in vitro evaluated against HSV-1 in Vero cells; among these an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::18f507d54981b37716e50950fff9c036
https://doi.org/10.1007/s00044-011-9574-8
https://doi.org/10.1007/s00044-011-9574-8
Autor:
Alaa El-Din M. Barghash, Abdelbasset A. Farahat, Reto Brun, Leah Mickelson, Tanja Wenzler, Fatma E. Goda, W. David Wilson, Arvind Kumar, Yang Liu, David W. Boykin, Hassan M. Eisa, Martial Say
Publikováno v:
Bioorganic & Medicinal Chemistry. 18:557-566
A novel series of extended DAPI analogues were prepared by insertion of either a carbon-carbon triple bond (16a-d) or a phenyl group (21a,b and 24) at position-2. The new amidines were evaluated in vitro against both Trypanosoma brucei rhodesiense (T
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2c789350dc9ed041f4cb0f81bdd449ef
https://doi.org/10.1016/j.bmc.2009.12.011
https://doi.org/10.1016/j.bmc.2009.12.011
Autor:
Arvind Kumar, Abdelbasset A. Farahat, Hassan M. Eisa, Fatma E. Goda, Alaa El-Din M. Barghash, David W. Boykin
Publikováno v:
Journal of heterocyclic chemistry. 47(1)
Syntheses of new formyl ester- and cyano ester-substituted bithiophenes, bifurans, and furanothiophenes in good yield are described. The key synthetic step uses Stille coupling of appropriately substituted bromo 5-ring heterocycles with stannyl-subst
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::663c7f738840eb5640f2568c27d4949f
https://pubmed.ncbi.nlm.nih.gov/24634543
https://pubmed.ncbi.nlm.nih.gov/24634543