Zobrazeno 1 - 9 of 9 pro vyhledávání: '"Hassan Choucair"'
1
Inclusion of the in-chain sulfur in 3-thiaCTU increases the efficiency of mitochondrial targeting and cell killing by anticancer aryl-urea fatty acids
Autor: Md Khalilur Rahman, Balasubrahmanyam Umashankar, Hassan Choucair, Curtis Pazderka, Kirsi Bourget, Yongjuan Chen, Colin R. Dunstan, Tristan Rawling, Michael Murray
Publikováno v: European Journal of Pharmacology. 939:175470
Mitochondria in tumor cells are functionally different from those in normal cells and could be targeted to develop new anticancer agents. We showed recently that the aryl-ureido fatty acid CTU is the prototype of a new class of mitochondrion-targeted
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::04ca31c6914522ce3382dd8fee069520
https://doi.org/10.1016/j.ejphar.2022.175470
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2
The aryl-ureido fatty acid CTU activates endoplasmic reticulum stress and PERK/NOXA-mediated apoptosis in tumor cells by a dual mitochondrial-targeting mechanism
Autor: Yassir Al-Zubaidi, Colin R. Dunstan, Hassan Choucair, Kirsi Bourget, Balasubrahmanyam Umashankar, Tristan Rawling, Michael Murray, Khalilur Rahman, Yongjuan Chen
The cancer cell mitochondrion is functionally different from that in normal cells and could be targeted to develop novel experimental therapeutics. The aryl-ureido fatty acid CTU (16({[4-chloro-3-(trifluoromethyl)phenyl]-carbamoyl}amino)hexadecanoic
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5fa2c8e261a384e22d6874b99739fde0
https://hdl.handle.net/10453/166006
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3
A Novel Arylurea Fatty Acid That Targets the Mitochondrion and Depletes Cardiolipin To Promote Killing of Breast Cancer Cells
Autor: Sarah E. Allison, Tristan Rawling, Colin R. Dunstan, Michael Murray, Hassan Choucair, Nooshin Koolaji, Yongjuan Chen, Kirsi Bourget
Publikováno v: Journal of Medicinal Chemistry. 60:8661-8666
© 2017 American Chemical Society. Cancer cell mitochondria are promising anticancer drug targets because they control cell death and are structurally and functionally different from normal cell mitochondria. We synthesized arylurea fatty acids and f
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b239914ab70a3dcde3edd8235c7d3d48
https://doi.org/10.1021/acs.jmedchem.7b00701
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4
Abstract A119: Inhibition of IRE1-mediated pro-tumorigenic responses enhances the sensitivity of MDA-MB-231 cells to the novel arylurea-fatty acid CTU
Autor: Charlotte Smith, Khalilur Rahman, Yongjuan Chen, Stanton Tam, Hassan Choucair, Yassir Al-Zubaidi, Tristan Rawling, Michael Murray, Kirsi Bourget, Bala Umashankar
Publikováno v: Molecular Cancer Therapeutics. 18:A119-A119
There is an unmet need for new agents with low toxicity for treatment of triple-negative breast cancer (TNBC) because current approaches are limited to toxic drug combinations of low efficacy. We recently identified an aryl-substituted fatty acid ana
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::68c16d5a09e7b07aa3725ef16c413677
https://doi.org/10.1158/1535-7163.targ-19-a119
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5
Aryl-urea fatty acids that activate the p38 MAP kinase and down-regulate multiple cyclins decrease the viability of MDA-MB-231 breast cancer cells
Autor: Michael Murray, Hassan Choucair, Khalilur Rahman, Yongjuan Chen, Nooshin Koolaji, Curtis Pazderka, Kirsi Bourget, Bala Umashankar, Yassir Al-Zubaidi, Tristan Rawling
Publikováno v: European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences. 129
© 2019 Elsevier B.V. We recently developed a novel aryl-urea fatty acid (CTU; 16({[4-chloro-3-(trifluoromethyl)phenyl]carbamoyl}amino)hexadecanoic acid) that impaired the viability of MDA-MB-231 breast cancer cells in vitro and in mouse xenograft mo
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::73e64fd992459afa5028d914dbe8a114
https://pubmed.ncbi.nlm.nih.gov/30597206
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7
O25 A novel synthetic ω-3 fatty acid epoxide analogue activates breast cancer cell killing in vitro and in vivo
Autor: Sarah E. Allison, Tristan Rawling, Colin R. Dunstan, Yongjuan Chen, Hassan Choucair, Michael Murray, Kirsi Bourget
Publikováno v: Biochemical Pharmacology. 139:117
Triple-negative breast cancer (TNBC) has a poor prognosis and new drugs are urgently needed. The CYP-derived ω-3 epoxyeicosapentaenoic acid and its saturated analogues were found to activate apoptosis in MDA-MB-231 TNBC cells [1] , [2] , but in vivo
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::7b342772ed559b09420ff4ab06325354
https://doi.org/10.1016/j.bcp.2017.06.090
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9
Analyzing Field Failures of Engine Valve Springs in Presence of Non Metallic Inclusions by Applying Statistical and Fracture Mechanics Models
Autor: Hassan Choucair, Badih Jawad
Publikováno v: Volume 4: Design and Manufacturing.
An Engine valve spring, which is made of high strength, clean steel, is a very important component in an engine for controlling the movement of exhaust and the intake valve. It is designed to survive an infinite life under high cyclic stress. Hence,
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::07673617b75406720a56366a018ca92d
https://doi.org/10.1115/imece2009-10060
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