Zobrazeno 1 - 10
of 42
pro vyhledávání: '"Hassan Benameur"'
Autor:
Erin Tay, Tri-Hung Nguyen, Leigh Ford, Hywel D. Williams, Hassan Benameur, Peter J. Scammells, Christopher J. H. Porter
Publikováno v:
Pharmaceutics, Vol 12, Iss 1, p 17 (2019)
Lipid based formulations (LBFs) are commonly employed to enhance the absorption of highly lipophilic, poorly water-soluble drugs. However, the utility of LBFs can be limited by low drug solubility in the formulation. Isolation of ionizable drugs as l
Externí odkaz:
https://doaj.org/article/074cf2e8c38941079d00125509fd46b4
Publikováno v:
Oral Drug Delivery for Modified Release Formulations. :235-252
Autor:
Colin W. Pouton, Shadabul Haque, Endri Kastrati, Vincent Jannin, Mitchell P. McInerney, David K. Chalmers, Karen M. Corbett, Christopher J.H. Porter, Leigh Ford, Hassan Benameur, Hywel David Williams, Dallas B. Warren
Publikováno v:
Pharmaceutical Research. 38:1531-1547
Molecular dynamics (MD) simulations provide an in silico method to study the structure of lipid-based formulations (LBFs) and the incorporation of poorly water-soluble drugs within such formulations. In order to validate the ability of MD to effectiv
Autor:
Philip E. Thompson, Hywel David Williams, Peter J. Scammells, Shadabul Haque, Mitchell P. McInerney, Peng Li, Hassan Benameur, Vincent Jannin, Christopher J.H. Porter, Colin W. Pouton, Leigh Ford
Publikováno v:
Pharmaceutical Research. 38:1125-1137
Successful oral peptide delivery faces two major hurdles: low enzymatic stability in the gastro-intestinal lumen and poor intestinal membrane permeability. While lipid-based formulations (LBF) have the potential to overcome these barriers, effective
Publikováno v:
Journal of Colloid and Interface Science. 588:257-268
Hypothesis Non-ionic surfactants containing polyethylene oxide (PEO) chains are widely used in drug formulations, cosmetics, paints, textiles and detergents. High quality molecular dynamics models for PEO surfactants can give us detailed, atomic-scal
Autor:
Anthony Lai, Nathania Leong, Dan Zheng, Leigh Ford, Tri-Hung Nguyen, Hywel D. Williams, Hassan Benameur, Peter J. Scammells, Christopher J. H. Porter
Publikováno v:
Pharmaceutical research. 39(10)
Purpose The use of ionic liquids (ILs) in drug delivery has focused attention on non-toxic IL counterions. Cationic lipids can be used to form ILs with weakly acidic drugs to enhance drug loading in lipid-based formulations (LBFs). However, cationic
Autor:
Mladen V. Tzvetkov, Aurélien Sivert, Maximilian Sager, Marie-Luise Kromrey, Philipp Schick, Werner Weitschies, Simon Merdivan, Philipp Aude, Hassan Benameur, Mahmoud Hasan, Mirko Koziolek, Michael Grimm
Publikováno v:
Journal of Controlled Release. 313:24-32
The instability of various small molecules, vaccines and peptides in the human stomach is a complex challenge for oral drug delivery. Recently, a novel gastro-resistant capsule - the enTRinsic™ Drug Delivery Technology capsule - has been developed.
Autor:
Colin W. Pouton, Amali G. Guruge, David K. Chalmers, Dallas B. Warren, Hywel David Williams, Vincent Jannin, Hassan Benameur, Leigh Ford
Publikováno v:
Molecular pharmaceutics. 18(12)
Type III lipid-based formulations (LBFs) combine poorly water-soluble drugs with oils, surfactants, and cosolvents to deliver the drugs into the systemic circulation. However, the solubility of the drug can be influenced by the colloidal phases forme
Autor:
Guixian Hu, Annabel Igonin, Leigh Ford, Peter J. Scammells, Paolo Botti, Hywel David Williams, Zhenhua Shan, Michael M. Morgen, Hassan Benameur, Christopher J.H. Porter, Colin W. Pouton
Publikováno v:
Advanced Drug Delivery Reviews. 142:75-90
Lipid-based formulations (LBF) are widely used by industry and accepted by the regulatory authorities for oral drug delivery in the pharmaceutical and consumer healthcare market. Innovation in the LBF field is however needed in order to meet the dema
Autor:
Felix Schneider, Elisabeth Scholz, Marie-Luise Kromrey, Werner Weitschies, Jens-Peter Kühn, Katharina Ball, Michael Grimm, Hassan Benameur, Aurélien Sivert
Publikováno v:
European Journal of Pharmaceutical Sciences. 129:163-172
The application areas of hard capsules are currently widened by the introduction of acid-resistant capsule shells. In this study, the gastrointestinal behavior of acid-resistant hard capsule formulations as well as the influence of their density on t