Zobrazeno 1 - 10
of 197
pro vyhledávání: '"Hassan, Jumaa"'
Autor:
Anastasia Iatrou, Palash C Maity, Alexandra Theresa Linder, Andreas Agathangelidis, Michela Frenquelli, Raphael Sandaltzopoulos, Massimo Degano, Anastasia Chatzidimitriou, Paolo Ghia, Hassan Jumaa, Kostas Stamatopoulos
Publikováno v:
HemaSphere, Vol 7, p e8483669 (2023)
Externí odkaz:
https://doaj.org/article/03f3c9c556304d8a81ba8c3cdae75343
Autor:
Edwin Quinten, Julieta H. Sepúlveda-Yáñez, Marvyn T. Koning, Janneke A. Eken, Dietmar Pfeifer, Valeri Nteleah, Ruben A.L. de Groen, Diego Alvarez Saravia, Jeroen Knijnenburg, Hedwig E. Stuivenberg-Bleijswijk, Milena Pantic, Andreas Agathangelidis, Andrea Keppler-Hafkemeyer, Cornelis A. M. van Bergen, Roberto Uribe-Paredes, Kostas Stamatopoulos, Joost S.P. Vermaat, Katja Zirlik, Marcelo A. Navarrete, Hassan Jumaa, Hendrik Veelken
Publikováno v:
Haematologica, Vol 109, Iss 3 (2023)
Clonal expansion of CD5-expressing B cells, commonly designated as monoclonal B lymphocytosis (MBL), is a precursor condition for chronic lymphocytic leukemia (CLL). The mechanisms driving subclinical MBL B-cell expansion and progression to CLL, occu
Externí odkaz:
https://doaj.org/article/dba465a131f946e396c780476e81d2fc
Autor:
Franz Ketzer, Hend Abdelrasoul, Mona Vogel, Ralf Marienfeld, Markus Müschen, Hassan Jumaa, Thomas Wirth, Alexey Ushmorov
Publikováno v:
Oncogenesis, Vol 11, Iss 1, Pp 1-12 (2022)
Abstract The D-type cyclins (CCND1, CCND2, and CCND3) in association with CDK4/6 are known drivers of cell cycle progression. We reported previously that inactivation of FOXO1 confers growth arrest and apoptosis in B-ALL, partially mediated by subseq
Externí odkaz:
https://doaj.org/article/cd3fcf0a0bbb43f9a95cf28d3dfc64d4
Autor:
Mirja Harms, Monica M.W. Habib, Simona Nemska, Antonella Nicolò, Andrea Gilg, Nico Preising, Pandian Sokkar, Sara Carmignani, Martina Raasholm, Gilbert Weidinger, Gönül Kizilsavas, Manfred Wagner, Ludger Ständker, Ashraf H. Abadi, Hassan Jumaa, Frank Kirchhoff, Nelly Frossard, Elsa Sanchez-Garcia, Jan Münch
Publikováno v:
Acta Pharmaceutica Sinica B, Vol 11, Iss 9, Pp 2694-2708 (2021)
Aberrant CXCR4/CXCL12 signaling is involved in many pathophysiological processes such as cancer and inflammatory diseases. A natural fragment of serum albumin, named EPI-X4, has previously been identified as endogenous peptide antagonist and inverse
Externí odkaz:
https://doaj.org/article/877b759cf88f4e9a87e25611fe551bb2
Autor:
Antonella Nicolò, Timm Amendt, Omar El Ayoubi, Marc Young, Stephanie Finzel, Makbule Senel, Reinhard E. Voll, Hassan Jumaa
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
Rheumatoid arthritis is an autoimmune disease characterized by joint inflammation due to autoantibodies targeting multiple self-proteins. Most patients with poor prognosis show elevated titers of IgM antibodies specifically binding to IgG. Such autor
Externí odkaz:
https://doaj.org/article/6859fa3d505e4ce3bf14bb6b4b83ddae
Autor:
Lennart Lenk, Dorothee Winterberg, Fotini Vogiatzi, Anna Laqua, Lea Spory, Ahmad Mayar, Anna Dietterle, Gina Münch, Christian Vokuhl, Julia Richter, Andrew G. Polson, Thomas Schüler, Ulf D. Kahlert, Matthias Peipp, Thomas Valerius, Martin Schrappe, Gunnar Cario, Hassan Jumaa, Elias Hobeika, Monika Brüggemann, Ameera Alsadeq, Denis M. Schewe
Publikováno v:
HemaSphere, Vol 6, Iss 8, p e754 (2022)
Externí odkaz:
https://doaj.org/article/ee2a0191775641108c609751c3210508
Autor:
Lennart Lenk, Michela Carlet, Fotini Vogiatzi, Lea Spory, Dorothee Winterberg, Antony Cousins, Michaela Vossen-Gajcy, Olta Ibruli, Christian Vokuhl, Gunnar Cario, Omar El Ayoubi, Lisa Kramer, Matthias Ritgen, Monika Brüggemann, Robert Häsler, Martin Schrappe, Stephan Fuhrmann, Christina Halsey, Irmela Jeremias, Elias Hobeika, Hassan Jumaa, Ameera Alsadeq, Denis M. Schewe
Publikováno v:
Communications Biology, Vol 4, Iss 1, Pp 1-6 (2021)
Lenk et al find that the preB cell receptor (preBCR) is associated with infiltration and relapse of acute lymphoblastic leukemia in the central nervous system (CNS). They also show that downregulation of preBCR component CD79a reduces the engraftment
Externí odkaz:
https://doaj.org/article/45d481a21f3e44e49b4f84076c7e9181
Autor:
Anila Vadakumchery, Hemin Faraidun, Omar El Ayoubi, Issame Outaleb, Vera Schmid, Hend Abdelrasoul, Timm Amendt, Ahmad Khadour, Corinna Setz, Katharina Göhring, Karoline Lodd, Christoffer Hitzing, Alabbas Alkhatib, Mayas Bilal, Julian Benckendorff, Abdul Kader Al Shugri, Cord Herbert Brakebusch, Niklas Engels, Moumita Datta, Elias Hobeika, Ameera Alsadeq, Hassan Jumaa
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
The generation, differentiation, survival and activation of B cells are coordinated by signals emerging from the B cell antigen receptor (BCR) or its precursor, the pre-BCR. The adaptor protein SLP65 (also known as BLNK) is an important signaling fac
Externí odkaz:
https://doaj.org/article/bba221cfcb304def8ce9db2a80eaa6fd
Autor:
Hend Abdelrasoul, Anila Vadakumchery, Markus Werner, Lennart Lenk, Ahmad Khadour, Marc Young, Omar El Ayoubi, Fotini Vogiatzi, Markus Krämer, Vera Schmid, Zhengshan Chen, Yasar Yousafzai, Gunnar Cario, Martin Schrappe, Markus Müschen, Christina Halsey, Medhanie A. Mulaw, Denis M. Schewe, Elias Hobeika, Ameera Alsadeq, Hassan Jumaa
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-12 (2020)
Emergence of ABL1 kinase inhibitor resistant clones may cause disease relapse in Philadelphia chromosome-positive acute lymphoblastic leukemia. Here, the authors show interleukin 7 receptor (IL7R) signaling to contribute to this resistance mechanism,
Externí odkaz:
https://doaj.org/article/a25003f7a49e4b7f9022e8001e0418c9
Autor:
Vera Kristin Schmid, Ahmad Khadour, Nabil Ahmed, Carolin Brandl, Lars Nitschke, Klaus Rajewsky, Hassan Jumaa, Elias Hobeika
Publikováno v:
Haematologica, Vol 107, Iss 8 (2022)
Chronic lymphocytic leukemia (CLL) is a frequent lymphoproliferative disorder of B cells. Although inhibitors targeting signal proteins involved in B-cell antigen receptor (BCR) signaling constitute an important part of the current therapeutic protoc
Externí odkaz:
https://doaj.org/article/e5c0a11a07cd48aebe8e319f62fac762