Correction to Discovery of Novel 3-Quinoline Carboxamides as Potent, Selective, and Orally Bioavailable Inhibitors of Ataxia Telangiectasia Mutated (ATM) Kinase.

Autor: Degorce SL, Barlaam B, Cadogan E, Dishington A, Ducray R, Glossop SC, Hassall LA, Lach F, Lau A, McGuire TM, Nowak T, Ouvry G, Pike KG, Thomason AG

Publikováno v: Journal of medicinal chemistry [J Med Chem] 2018 Jul 26; Vol. 61 (14), pp. 6398. Date of Electronic Publication: 2018 Jul 03.

The Identification of Potent, Selective, and Orally Available Inhibitors of Ataxia Telangiectasia Mutated (ATM) Kinase: The Discovery of AZD0156 (8-{6-[3-(Dimethylamino)propoxy]pyridin-3-yl}-3-methyl-1-(tetrahydro-2 H-pyran-4-yl)-1,3-dihydro-2 H-imidazo[4,5- c]quinolin-2-one).

Autor: Pike KG; Oncology, IMED Biotech Unit , AstraZeneca , Building 310, Cambridge Science Park, 319 Milton Road , Cambridge CB4 0WG , U.K., Barlaam B; Oncology, IMED Biotech Unit , AstraZeneca , Building 310, Cambridge Science Park, 319 Milton Road , Cambridge CB4 0WG , U.K., Cadogan E; Oncology, IMED Biotech Unit , AstraZeneca , Building 310, Cambridge Science Park, 319 Milton Road , Cambridge CB4 0WG , U.K., Campbell A; Pharmaceutical Sciences , AstraZeneca , Silk Road Business Park, Macclesfield SK10 2NA , U.K., Chen Y; Oncology, IMED Biotech Unit , AstraZeneca , 35 Gatehouse Drive , Waltham , Massachusetts 02451 , United States., Colclough N; Oncology, IMED Biotech Unit , AstraZeneca , Building 310, Cambridge Science Park, 319 Milton Road , Cambridge CB4 0WG , U.K., Davies NL; Oncology, IMED Biotech Unit , AstraZeneca , Building 310, Cambridge Science Park, 319 Milton Road , Cambridge CB4 0WG , U.K., de-Almeida C; Oncology, IMED Biotech Unit , AstraZeneca , Building 310, Cambridge Science Park, 319 Milton Road , Cambridge CB4 0WG , U.K., Degorce SL; Oncology, IMED Biotech Unit , AstraZeneca , Building 310, Cambridge Science Park, 319 Milton Road , Cambridge CB4 0WG , U.K.; Oncology, IMED Biotech Unit , AstraZeneca, Centre de Recherches, Z. I. la Pompelle , BP 1050, 51689 Reims Cedex 2 , France., Didelot M; Oncology, IMED Biotech Unit , AstraZeneca, Centre de Recherches, Z. I. la Pompelle , BP 1050, 51689 Reims Cedex 2 , France., Dishington A; Oncology, IMED Biotech Unit , AstraZeneca , Alderley Park , Macclesfield , Cheshire SK10 4TG , U.K., Ducray R; Oncology, IMED Biotech Unit , AstraZeneca, Centre de Recherches, Z. I. la Pompelle , BP 1050, 51689 Reims Cedex 2 , France., Durant ST; Oncology, IMED Biotech Unit , AstraZeneca , Building 310, Cambridge Science Park, 319 Milton Road , Cambridge CB4 0WG , U.K., Hassall LA; Oncology, IMED Biotech Unit , AstraZeneca , Alderley Park , Macclesfield , Cheshire SK10 4TG , U.K., Holmes J; Oncology, IMED Biotech Unit , AstraZeneca , Alderley Park , Macclesfield , Cheshire SK10 4TG , U.K., Hughes GD; Oncology, IMED Biotech Unit , AstraZeneca , Building 310, Cambridge Science Park, 319 Milton Road , Cambridge CB4 0WG , U.K., MacFaul PA; Oncology, IMED Biotech Unit , AstraZeneca , Alderley Park , Macclesfield , Cheshire SK10 4TG , U.K., Mulholland KR; Chemical Development , AstraZeneca , Silk Road Business Park , Macclesfield SK10 2NA , U.K., McGuire TM; Oncology, IMED Biotech Unit , AstraZeneca , Building 310, Cambridge Science Park, 319 Milton Road , Cambridge CB4 0WG , U.K., Ouvry G; Oncology, IMED Biotech Unit , AstraZeneca, Centre de Recherches, Z. I. la Pompelle , BP 1050, 51689 Reims Cedex 2 , France., Pass M; Oncology, IMED Biotech Unit , AstraZeneca , Building 310, Cambridge Science Park, 319 Milton Road , Cambridge CB4 0WG , U.K., Robb G; Oncology, IMED Biotech Unit , AstraZeneca , Building 310, Cambridge Science Park, 319 Milton Road , Cambridge CB4 0WG , U.K., Stratton N; Discovery Sciences , AstraZeneca , Alderley Park , Macclesfield , Cheshire SK10 4TG , U.K., Wang Z; Pharmaron Beijing Co., Ltd. , 6 Taihe Road BDA , Beijing 100176 , P.R. China., Wilson J; Oncology, IMED Biotech Unit , AstraZeneca , Building 310, Cambridge Science Park, 319 Milton Road , Cambridge CB4 0WG , U.K., Zhai B; Pharmaron Beijing Co., Ltd. , 6 Taihe Road BDA , Beijing 100176 , P.R. China., Zhao K; Pharmaron Beijing Co., Ltd. , 6 Taihe Road BDA , Beijing 100176 , P.R. China., Al-Huniti N; Oncology, IMED Biotech Unit , AstraZeneca , 35 Gatehouse Drive , Waltham , Massachusetts 02451 , United States.

Publikováno v: Journal of medicinal chemistry [J Med Chem] 2018 May 10; Vol. 61 (9), pp. 3823-3841. Date of Electronic Publication: 2018 May 02.

Preparation of 1-Substituted Tetrahydro-β-carbolines by Lithiation-Substitution.

Autor: Cochrane EJ; †Department of Chemistry, University of Sheffield, Sheffield S3 7HF, United Kingdom., Hassall LA; ‡AstraZeneca, Alderley Park, Macclesfield, Cheshire SK10 4TG, United Kingdom., Coldham I; †Department of Chemistry, University of Sheffield, Sheffield S3 7HF, United Kingdom.

Publikováno v: The Journal of organic chemistry [J Org Chem] 2015 Jun 05; Vol. 80 (11), pp. 5964-9. Date of Electronic Publication: 2015 May 22.

DNA damage repair in glioblastoma: current perspectives on its role in tumour progression, treatment resistance and PIKKing potential therapeutic targets.

Autor: Lozinski, Mathew^1,2,3 (AUTHOR), Bowden, Nikola A.^2,3,4 (AUTHOR), Graves, Moira C.^2,3,4 (AUTHOR), Fay, Michael^2,3,5 (AUTHOR), Tooney, Paul A.^1,2,3 (AUTHOR) paul.tooney@newcastle.edu.au

Publikováno v: Cellular Oncology (2211-3428). Oct2021, Vol. 44 Issue 5, p961-981. 21p.

Association Des Physiologistes: Travaux divers présentés en 1986-1987.

Publikováno v: Archives Internationales de Physiologie et de Biochimie; 1988, Vol. 96 Issue 2, pA1-A26, 26p