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pro vyhledávání: '"Hasnain A. Malik"'
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Autor:
Jack C. Sharland, David Dunstan, Dyuti Majumdar, Jinhai Gao, Kian Tan, Hasnain A. Malik, Huw M. L. Davies
Publikováno v:
ACS Catalysis. 12:12530-12542
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9170650e805c33ef385a0d4ea1edd04a
https://doi.org/10.1021/acscatal.2c03909
https://doi.org/10.1021/acscatal.2c03909
Autor:
Huw M. L. Davies, Jacob N. Sanders, Christian M. Gampe, Zachary J. Garlets, K. N. Houk, Hasnain A. Malik
Publikováno v:
Nature Catalysis. 3:351-357
Bicyclo[1.1.1]pentanes (BCPs) are highly strained carbocycles that have fascinated the chemical community for decades because of their unique structure. Despite the immense interest in this scaffold and extensive synthetic efforts, the construction o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::399ef9383f47ad1774f1e19bf0e2b2cd
https://doi.org/10.1038/s41929-019-0417-1
https://doi.org/10.1038/s41929-019-0417-1
Autor:
Noel Marie-France Thomsen, Simone Bonazzi, Stephanie M. McTighe, Guiqing Liang, Danuta Lubicka, Sarah Salas, Jill Nunez, Franco Lombardo, Rajeshri Ganesh Karki, Audrey Gray, Stefan Peukert, Doug Burdette, Jean-Cosme Dodart, Leon Murphy, Grazia Piizzi, Carleton Goold, Labbe-Giguere Nancy, Erin P. Keaney, Jonathan D. Biag, Christine D. Wilson, Aakruti Gorde, Lawrence G. Hamann, Yingchuan Sun, Lin Deng, Hasnain A. Malik, Daniel Curtis, Shanming Liu
Publikováno v:
Journal of medicinal chemistry. 63(3)
Recent clinical evaluation of everolimus for seizure reduction in patients with tuberous sclerosis complex (TSC), a disease with overactivated mechanistic target of rapamycin (mTOR) signaling, has demonstrated the therapeutic value of mTOR inhibitors
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3487e6cec3e46116122d50f027546e53
https://pubmed.ncbi.nlm.nih.gov/31955578
https://pubmed.ncbi.nlm.nih.gov/31955578
Publikováno v:
Journal of the American Chemical Society. 139:9317-9324
An exceptionally hindered class of enantiopure NHC ligands has been developed. While racemic forms had previously been utilized, a scalable and practical route to the enantiopure form of this ligand class is described utilizing a two-directional Buch
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8f8fb34730e9838115b42913b6a1509f
https://doi.org/10.1021/jacs.7b04583
https://doi.org/10.1021/jacs.7b04583
Autor:
Eugen Lounkine, Meir Glick, Hasnain A. Malik, Anne Mai Wassermann, Peter S. Kutchukian, Sandra W. Cowan-Jacob, Tiffany Luethi, Michael Bocker, Jacques Hamon
Publikováno v:
Journal of Medicinal Chemistry. 56:8879-8891
We introduce a novel strategy to sample bioactive chemical space, which follows-up on hits from fragment campaigns without the need for a crystal structure. Our results strongly suggest that screening a few hundred or thousand fragments can substanti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b7c3965e89ac5d7136c48dfe16661bb8
https://doi.org/10.1021/jm401309q
https://doi.org/10.1021/jm401309q
Publikováno v:
ChemInform. 47
A comparative study is disclosed that seeks to highlight the current limitations and challenges that exist in the field of atom-transfer C–H oxidations. State-of-the-art methods are benchmarked in order to showcase clear differences and similaritie
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f7345c94173b5ca8bb983038fbecf87e
https://doi.org/10.1002/chin.201618041
https://doi.org/10.1002/chin.201618041
Publikováno v:
Organic Letters. 14:4806-4809
A diastereoselective approach to isochromans and chromans via Pd(0)-catalyzed carboiodination is reported. The transformations using this methodology display excellent yields and diastereoselectivities as well as broad functional group compatibility.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d340e39094b90402b3707b00f9f5a82c
https://doi.org/10.1021/ol302111y
https://doi.org/10.1021/ol302111y
Publikováno v:
Organic letters. 17(24)
A comparative study is disclosed that seeks to highlight the current limitations and challenges that exist in the field of atom-transfer C–H oxidations. State-of-the-art methods are benchmarked in order to showcase clear differences and similaritie
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::36a9fae68df476eb2d3a9da6ee635148
https://pubmed.ncbi.nlm.nih.gov/26649767
https://pubmed.ncbi.nlm.nih.gov/26649767
Publikováno v:
Organic Letters. 11:5734-5737
The nickel-catalyzed reductive coupling of propargyl alcohols and alkynes proceeds with excellent regiochemical control with an underlying electronic preference that can be supplemented by ligand size effects. The products obtained may be readily con
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c4816b4fcd400f5ef37cdaeaeb31c51b
https://doi.org/10.1021/ol902561r
https://doi.org/10.1021/ol902561r