Zobrazeno 1 - 10
of 13
pro vyhledávání: '"Hasna Maachi"'
Autor:
Sapna Puri, Hasna Maachi, Gopika Nair, Holger A. Russ, Richard Chen, Pamela Pulimeno, Zachary Cutts, Vasilis Ntranos, Matthias Hebrok
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-17 (2024)
Abstract Despite significant research, mechanisms underlying the failure of islet beta cells that result in type 2 diabetes (T2D) are still under investigation. Here, we report that Sox9, a transcriptional regulator of pancreas development, also func
Externí odkaz:
https://doaj.org/article/78e918df306c49569dad84919d98da27
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-15 (2021)
Abstract The potential to treat diabetes by increasing beta-cell mass is driving a major effort to identify beta-cell mitogens. Demonstration of mitogen activity in human beta cells is frequently performed in ex vivo assays. However, reported dispari
Externí odkaz:
https://doaj.org/article/0c5672ccf4384164a7461795c4eafad4
Autor:
Kevin Vivot, Valentine S. Moullé, Bader Zarrouki, Caroline Tremblay, Arturo D. Mancini, Hasna Maachi, Julien Ghislain, Vincent Poitout
Publikováno v:
Molecular Metabolism, Vol 5, Iss 10, Pp 988-996 (2016)
Objective: G protein-coupled receptor (GPCR) signaling regulates insulin secretion and pancreatic β cell-proliferation. While much knowledge has been gained regarding how GPCRs are activated in β cells, less is known about the mechanisms controllin
Externí odkaz:
https://doaj.org/article/ad1ede006bf142c780de5ff77a012db7
Autor:
Hasna Maachi, Isabelle Chenier, Muhammad Abdul Lateef, Shao-Ling Zhang, Janos G. Filep, John S. D. Chan, Julie R. Ingelfinger, Chao-Sheng Lo, Shuiling Zhao, Shaaban Abdo, Anindya Ghosh
Publikováno v:
Scientific Reports, Vol 9, Iss 1, Pp 1-16 (2019)
Scientific Reports
Scientific Reports
We investigated the molecular mechanism(s) by which insulin prevents Bcl2-modifying factor (Bmf)-induced renal proximal tubular cell (RPTC) apoptosis and loss in diabetic mice. Transgenic mice (Tg) mice specifically overexpressing human BMF in RPTCs
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dd0398058c28df0e8899a8bf6ab1d558
http://link.springer.com/article/10.1038/s41598-019-43218-2
http://link.springer.com/article/10.1038/s41598-019-43218-2
Publikováno v:
Scientific Reports
Scientific Reports, Vol 11, Iss 1, Pp 1-15 (2021)
Scientific Reports, Vol 11, Iss 1, Pp 1-15 (2021)
The potential to treat diabetes by increasing beta-cell mass is driving a major effort to identify beta-cell mitogens. Demonstration of mitogen activity in human beta cells is frequently performed in ex vivo assays. However, reported disparities in t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7a6e1098ce7701d4e9052388bd7fe42b
https://doi.org/10.1038/s41598-021-90643-3
https://doi.org/10.1038/s41598-021-90643-3
Combined Deletion of Free Fatty-Acid Receptors 1 and 4 Minimally Impacts Glucose Homeostasis in Mice
Autor:
Julien Ghislain, Mélanie Ethier, Scott A. Campbell, Marine L. Croze, Hasna Maachi, Caroline Tremblay, Grace Fergusson, Arthur Guillaume, Vincent Poitout
Publikováno v:
Endocrinology. 162
The free fatty-acid receptors FFAR1 (GPR40) and FFAR4 (GPR120) are implicated in the regulation of insulin secretion and insulin sensitivity, respectively. Although GPR120 and GPR40 share similar ligands, few studies have addressed possible interacti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cd7594cb4f437a24aee9efda4bb826b0
https://doi.org/10.1210/endocr/bqab002
https://doi.org/10.1210/endocr/bqab002
Autor:
Mélanie Ethier, Liora S. Katz, Lee B Honig, Donald K. Scott, Mallikarjuna R. Metukuri, Vincent Poitout, Gabriel Brill, Julien Ghislain, Hasna Maachi, Grace Fergusson
Publikováno v:
Diabetes
The molecular mechanisms of β-cell compensation to metabolic stress are poorly understood. We previously observed that nutrient-induced β-cell proliferation in rats is dependent on Epidermal Growth Factor Receptor (EGFR) signaling. The aim of this
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7941aefe05cb3971db47282c6ab6fc95
https://doi.org/10.1101/683003
https://doi.org/10.1101/683003
Publikováno v:
Diabetes. 68
Background: Glucose is a major β-cell mitogen. Despite recent progress, the underlying mechanisms remain unclear. In a rat model of nutrient excess we previously showed that nutrient-induced β-cell proliferation is blocked when either EGF receptor
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3dbfd4ae1d84cc7ab4b24bf0603dbf01
https://doi.org/10.2337/db19-2196-p
https://doi.org/10.2337/db19-2196-p
Autor:
Valentine S. Moullé, Caroline Tremblay, Hasna Maachi, Julien Ghislain, Bader Zarrouki, Arturo Mancini, Kevin Vivot, Vincent Poitout
Publikováno v:
Molecular Metabolism
Molecular Metabolism, Vol 5, Iss 10, Pp 988-996 (2016)
Molecular Metabolism, Vol 5, Iss 10, Pp 988-996 (2016)
Objective G protein-coupled receptor (GPCR) signaling regulates insulin secretion and pancreatic β cell-proliferation. While much knowledge has been gained regarding how GPCRs are activated in β cells, less is known about the mechanisms controlling
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::34bdd484cef678d9612521e4be2c9885
http://europepmc.org/articles/PMC5034687
http://europepmc.org/articles/PMC5034687
Autor:
John S. D. Chan, Isabelle Chenier, Chao-Sheng Lo, Yixuan Shi, Shao-Ling Zhang, János G. Filep, Hasna Maachi, Julie R. Ingelfinger
Publikováno v:
American Journal of Physiology-Renal Physiology. 304:F1335-F1346
We investigated the relationship among oxidative stress, hypertension, renal injury, and angiotensin-converting enzyme-2 (ACE2) expression in type 1 diabetic Akita mice. Blood glucose, blood pressure, and albuminuria were monitored for up to 5 mo in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f82f3b507a7d4275b8fb7d5a0653a724
https://doi.org/10.1152/ajprenal.00405.2012
https://doi.org/10.1152/ajprenal.00405.2012