Zobrazeno 1 - 10
of 78
pro vyhledávání: '"Hasmik Keshishian"'
Autor:
Sameer Aryal, Kevin Bonanno, Bryan Song, D.R. Mani, Hasmik Keshishian, Steven A. Carr, Morgan Sheng, Borislav Dejanovic
Publikováno v:
Cell Reports, Vol 42, Iss 5, Pp 112497- (2023)
Summary: Synaptic dysfunction is implicated in the pathophysiology of schizophrenia (SCZ) and bipolar disorder (BP). We use quantitative mass spectrometry to carry out deep, unbiased proteomic profiling of synapses purified from the dorsolateral pref
Externí odkaz:
https://doaj.org/article/0709b3c745bc4d1e9ed02f715192f2bd
Autor:
Prasidda Khadka, Zachary J. Reitman, Sophie Lu, Graham Buchan, Gabrielle Gionet, Frank Dubois, Diana M. Carvalho, Juliann Shih, Shu Zhang, Noah F. Greenwald, Travis Zack, Ofer Shapira, Kristine Pelton, Rachel Hartley, Heather Bear, Yohanna Georgis, Spandana Jarmale, Randy Melanson, Kevin Bonanno, Kathleen Schoolcraft, Peter G. Miller, Alexandra L. Condurat, Elizabeth M. Gonzalez, Kenin Qian, Eric Morin, Jaldeep Langhnoja, Leslie E. Lupien, Veronica Rendo, Jeromy Digiacomo, Dayle Wang, Kevin Zhou, Rushil Kumbhani, Maria E. Guerra Garcia, Claire E. Sinai, Sarah Becker, Rachel Schneider, Jayne Vogelzang, Karsten Krug, Amy Goodale, Tanaz Abid, Zohra Kalani, Federica Piccioni, Rameen Beroukhim, Nicole S. Persky, David E. Root, Angel M. Carcaboso, Benjamin L. Ebert, Christine Fuller, Ozgun Babur, Mark W. Kieran, Chris Jones, Hasmik Keshishian, Keith L. Ligon, Steven A. Carr, Timothy N. Phoenix, Pratiti Bandopadhayay
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-18 (2022)
Abstract The role of PPM1D mutations in de novo gliomagenesis has not been systematically explored. Here we analyze whole genome sequences of 170 pediatric high-grade gliomas and find that truncating mutations in PPM1D that increase the stability of
Externí odkaz:
https://doaj.org/article/05d88dcae9c94b0ba00bbf84c4d8c770
A bidirectional switch in the Shank3 phosphorylation state biases synapses toward up- or downscaling
Autor:
Chi-Hong Wu, Vedakumar Tatavarty, Pierre M Jean Beltran, Andrea A Guerrero, Hasmik Keshishian, Karsten Krug, Melanie A MacMullan, Li Li, Steven A Carr, Jeffrey R Cottrell, Gina G Turrigiano
Publikováno v:
eLife, Vol 11 (2022)
Homeostatic synaptic plasticity requires widespread remodeling of synaptic signaling and scaffolding networks, but the role of post-translational modifications in this process has not been systematically studied. Using deep-scale quantitative analysi
Externí odkaz:
https://doaj.org/article/62dee5cecd974444b9a59db1da6ab44d
Autor:
Hasmik Keshishian, E Robert McDonald III, Filip Mundt, Randy Melanson, Karsten Krug, Dale A Porter, Luke Wallace, Dominique Forestier, Bokang Rabasha, Sara E Marlow, Judit Jane‐Valbuena, Ellen Todres, Harrison Specht, Margaret Lea Robinson, Pierre M Jean Beltran, Ozgun Babur, Meagan E Olive, Javad Golji, Eric Kuhn, Michael Burgess, Melanie A MacMullan, Tomas Rejtar, Karen Wang, DR Mani, Shankha Satpathy, Michael A Gillette, William R Sellers, Steven A Carr
Publikováno v:
Molecular Systems Biology, Vol 17, Iss 9, Pp n/a-n/a (2021)
Abstract Reliable methods to quantify dynamic signaling changes across diverse pathways are needed to better understand the effects of disease and drug treatment in cells and tissues but are presently lacking. Here, we present SigPath, a targeted mas
Externí odkaz:
https://doaj.org/article/8c21ac714ff142d89c9c58dde8847a35
Autor:
Yejin Lee, Hyeongju Kim, Douglas Barker, Ravi Vijayvargia, Ranjit Singh Atwal, Harrison Specht, Hasmik Keshishian, Steven A Carr, Ramee Lee, Seung Kwak, Kyung-gi Hyun, Jacob Loupe, Marcy E MacDonald, Ji-Joon Song, Ihn Sik Seong
Publikováno v:
Human Molecular Genetics. 32:30-45
Huntington’s disease (HD) is a neurodegenerative disorder caused by an inherited unstable HTT CAG repeat that expands further, thereby eliciting a disease process that may be initiated by polyglutamine-expanded huntingtin or a short polyglutamine-p
Autor:
Dos D. Sarbassov, David M. Sabatini, Mark A. Magnuson, Steven A. Carr, Hasmik Keshishian, Terri A. Addona, Timothy R. Peterson, Nitin K. Agarwal, Tattym Shaikenov, Chien-Hung Chen, Delphine Boulbes
Supplementary Data from Rictor Phosphorylation on the Thr-1135 Site Does Not Require Mammalian Target of Rapamycin Complex 2
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::23659829f88e380f269558fffa09aa25
https://doi.org/10.1158/1541-7786.22519155.v1
https://doi.org/10.1158/1541-7786.22519155.v1
Autor:
Dos D. Sarbassov, David M. Sabatini, Mark A. Magnuson, Steven A. Carr, Hasmik Keshishian, Terri A. Addona, Timothy R. Peterson, Nitin K. Agarwal, Tattym Shaikenov, Chien-Hung Chen, Delphine Boulbes
In animal cells, growth factors coordinate cell proliferation and survival by regulating the phosphoinositide 3-kinase/Akt signaling pathway. Deregulation of this signaling pathway is common in a variety of human cancers. The PI3K-dependent signaling
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c5107286051fc5b6ea843edffc7b7045
https://doi.org/10.1158/1541-7786.c.6542322.v1
https://doi.org/10.1158/1541-7786.c.6542322.v1
Autor:
Carla F. Kim, Tyler Jacks, Steven A. Carr, Lee Zou, Kwok-Kin Wong, Aaron N. Hata, Alice T. Shaw, Roderick T. Bronson, Angeliki Karatza, Hai Hu, Fei Li, Audris Oh, Chendi Li, D.R. Mani, Monica Schenone, Caroline R. Stanclift, Mary C. Beytagh, Margherita Paschini, Antoine Simoneau, Jonathan Y. Kim, Patrizia Pessina, Francisco J. Sanchez-Rivera, Christine F. Brainson, Arjun Bhutkar, Hasmik Keshishian, Caroline G. Fahey, Carla P. Concepcion, Manav Gupta
Figure S1 shows detailed RNA-sequencing analysis of patient samples as well as murine isogenic cell lines. Also presented here is further characterization of human isogenic models of BRG1 loss.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ba123dd21772c1f92dce43113c871efc
https://doi.org/10.1158/0008-5472.22425849
https://doi.org/10.1158/0008-5472.22425849
Autor:
Carla F. Kim, Tyler Jacks, Steven A. Carr, Lee Zou, Kwok-Kin Wong, Aaron N. Hata, Alice T. Shaw, Roderick T. Bronson, Angeliki Karatza, Hai Hu, Fei Li, Audris Oh, Chendi Li, D.R. Mani, Monica Schenone, Caroline R. Stanclift, Mary C. Beytagh, Margherita Paschini, Antoine Simoneau, Jonathan Y. Kim, Patrizia Pessina, Francisco J. Sanchez-Rivera, Christine F. Brainson, Arjun Bhutkar, Hasmik Keshishian, Caroline G. Fahey, Carla P. Concepcion, Manav Gupta
Differential RNA-seq analysis and list of all gene ontology and cancer reactome pathways found for top differentially upregulated genes in BRG1 mutant lung cancer patients compared to BRG1 wildtype patients, in the TCGA, PanCancer databases.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::06e71f348ecd52e0d7c476c872d37492
https://doi.org/10.1158/0008-5472.22425828
https://doi.org/10.1158/0008-5472.22425828
Autor:
Carla F. Kim, Tyler Jacks, Steven A. Carr, Lee Zou, Kwok-Kin Wong, Aaron N. Hata, Alice T. Shaw, Roderick T. Bronson, Angeliki Karatza, Hai Hu, Fei Li, Audris Oh, Chendi Li, D.R. Mani, Monica Schenone, Caroline R. Stanclift, Mary C. Beytagh, Margherita Paschini, Antoine Simoneau, Jonathan Y. Kim, Patrizia Pessina, Francisco J. Sanchez-Rivera, Christine F. Brainson, Arjun Bhutkar, Hasmik Keshishian, Caroline G. Fahey, Carla P. Concepcion, Manav Gupta
All figure legends for supplementary figures included here.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::19b650f31ead1dbbe16ff34a0dd49eb8
https://doi.org/10.1158/0008-5472.22425831
https://doi.org/10.1158/0008-5472.22425831