Multiple roles for hypoxia inducible factor 1-alpha in airway epithelial cells during mucormycosis.

Autor: Kavaliauskas P; Department of Microbiology and Immunology, University of Maryland School of Medicine, Baltimore, MD, 21201, USA., Gu Y; Division of Infectious Diseases, The Lundquist Institute for Biomedical Innovation, Harbor-UCLA Medical Center, Torrance, CA, 90502, USA., Hasin N; Institute for Genome Sciences, University of Maryland School of Medicine, Baltimore, MD, 21201, USA.; Millipore Sigma, 9900 Blackwell Road, Rockville, MD, 20850, USA., Graf KT; Institute for Genome Sciences, University of Maryland School of Medicine, Baltimore, MD, 21201, USA., Alqarihi A; Division of Infectious Diseases, The Lundquist Institute for Biomedical Innovation, Harbor-UCLA Medical Center, Torrance, CA, 90502, USA., Shetty AC; Institute for Genome Sciences, University of Maryland School of Medicine, Baltimore, MD, 21201, USA., McCracken C; Institute for Genome Sciences, University of Maryland School of Medicine, Baltimore, MD, 21201, USA., Walsh TJ; Department of Microbiology and Immunology, University of Maryland School of Medicine, Baltimore, MD, 21201, USA.; Center for Innovative Therapeutics and Diagnostics, 6641 West Broad St., Room 100, Richmond, VA, 23220, USA., Ibrahim AS; Division of Infectious Diseases, The Lundquist Institute for Biomedical Innovation, Harbor-UCLA Medical Center, Torrance, CA, 90502, USA.; David Geffen School of Medicine at UCLA, Los Angeles, CA, 90502, USA., Bruno VM; Department of Microbiology and Immunology, University of Maryland School of Medicine, Baltimore, MD, 21201, USA. vbruno@som.umaryland.edu.; Institute for Genome Sciences, University of Maryland School of Medicine, Baltimore, MD, 21201, USA. vbruno@som.umaryland.edu.

Publikováno v: Nature communications [Nat Commun] 2024 Jun 20; Vol. 15 (1), pp. 5282. Date of Electronic Publication: 2024 Jun 20.

Rare variants implicate NMDA receptor signaling and cerebellar gene networks in risk for bipolar disorder.

Autor: Hasin N; Institute for Genome Sciences, University of Maryland School of Medicine, Baltimore, MD, USA., Riggs LM; Program in Neuroscience and Training Program in Integrative Membrane Biology, University of Maryland School of Medicine, Baltimore, MD, USA.; Department of Psychiatry, University of Maryland School of Medicine, Baltimore, MD, USA., Shekhtman T; Department of Psychiatry, University of California San Diego, La Jolla, CA, USA., Ashworth J; Institute for Systems Biology, Seattle, WA, USA., Lease R; Institute for Genome Sciences, University of Maryland School of Medicine, Baltimore, MD, USA.; Program in Molecular Medicine, University of Maryland School of Medicine, Baltimore, MD, USA., Oshone RT; Institute for Genome Sciences, University of Maryland School of Medicine, Baltimore, MD, USA., Humphries EM; Institute for Genome Sciences, University of Maryland School of Medicine, Baltimore, MD, USA.; Program in Molecular Epidemiology, University of Maryland School of Medicine, Baltimore, MD, USA., Badner JA; Department of Psychiatry, Rush University Medical College, Chicago, IL, USA., Thomson PA; Institute of Genetics and Cancer, University of Edinburgh, Edinburgh, Scotland, UK., Glahn DC; Department of Psychiatry, Boston Children's Hospital, Harvard Medical School, Boston, MA, USA., Craig DW; Department of Translational Genomics, University of Southern California, Los Angeles, CA, USA., Edenberg HJ; Departments of Biochemistry and Molecular Biology and Medical and Molecular Genetics, Indiana University School of Medicine, Indianapolis, IN, USA., Gershon ES; Departments of Psychiatry and Human Genetics, University of Chicago, Chicago, IL, USA., McMahon FJ; Intramural Research Program, National Institute of Mental Health, Bethesda, MD, USA., Nurnberger JI; Department of Psychiatry, Indiana University School of Medicine, Indianapolis, IN, USA., Zandi PP; Department of Psychiatry and Behavioral Sciences, Johns Hopkins School of Medicine, Baltimore, MD, USA., Kelsoe JR; Department of Psychiatry, University of California San Diego, La Jolla, CA, USA., Roach JC; Institute for Systems Biology, Seattle, WA, USA., Gould TD; Department of Psychiatry, University of Maryland School of Medicine, Baltimore, MD, USA.; Departments of Pharmacology and Anatomy and Neurobiology, University of Maryland School of Medicine, Baltimore, MD, USA.; Veterans Affairs Maryland Health Care System, Baltimore, MD, USA., Ament SA; Institute for Genome Sciences, University of Maryland School of Medicine, Baltimore, MD, USA. sament@som.umaryland.edu.; Department of Psychiatry, University of Maryland School of Medicine, Baltimore, MD, USA. sament@som.umaryland.edu.

Publikováno v: Molecular psychiatry [Mol Psychiatry] 2022 Sep; Vol. 27 (9), pp. 3842-3856. Date of Electronic Publication: 2022 May 11.

Acetylation of the yeast Hsp40 chaperone protein Ydj1 fine-tunes proteostasis and translational fidelity.

Autor: Omkar, Siddhi¹ (AUTHOR), Mitchem, Megan M.¹ (AUTHOR), Hoskins, Joel R.² (AUTHOR), Shrader, Courtney¹ (AUTHOR), Kline, Jake T.³ (AUTHOR), Nitika¹ (AUTHOR), Fornelli, Luca³ (AUTHOR), Wickner, Sue² (AUTHOR), Truman, Andrew W.¹ (AUTHOR) a.truman@charlotte.edu

Publikováno v: PLoS Genetics. 12/9/2024, Vol. 20 Issue 12, p1-22. 22p.

The prototypical interferonopathy: Aicardi-Goutières syndrome from bedside to bench.

Autor: Hofer MJ; Charles Perkins Centre and School of Life and Environmental Sciences, The University of Sydney, New South Wales, Australia., Modesti N; Division of Neurology, Department of Pediatrics, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, USA., Coufal NG; Department of Pediatrics, University of California, San Diego, California, USA.; Rady Children's Hospital, San Diego, California, USA.; Sanford Consortium for Regenerative Medicine, San Diego, California, USA., Wang Q; Department of Surgery, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA., Sase S; Division of Neurology, Department of Pediatrics, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, USA., Miner JJ; Department of Medicine and Microbiology, RVCL Research Center, and Colton Center for Autoimmunity, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania, USA., Vanderver A; Division of Neurology, Department of Pediatrics, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, USA.; Department of Neurology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA., Bennett ML; Division of Neurology, Department of Pediatrics, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, USA.; Department of Neurology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA.

Publikováno v: Immunological reviews [Immunol Rev] 2024 Oct; Vol. 327 (1), pp. 83-99. Date of Electronic Publication: 2024 Oct 29.

Two RNase H2 Mutants with Differential rNMP Processing Activity Reveal a Threshold of Ribonucleotide Tolerance for Embryonic Development.

Autor: Uehara R; SFR, Division of Intramural Research, Eunice Kennedy Shriver National Institute of Child Health and Human Development, NIH, Bethesda, MD, USA., Cerritelli SM; SFR, Division of Intramural Research, Eunice Kennedy Shriver National Institute of Child Health and Human Development, NIH, Bethesda, MD, USA., Hasin N; SFR, Division of Intramural Research, Eunice Kennedy Shriver National Institute of Child Health and Human Development, NIH, Bethesda, MD, USA., Sakhuja K; SFR, Division of Intramural Research, Eunice Kennedy Shriver National Institute of Child Health and Human Development, NIH, Bethesda, MD, USA., London M; SFR, Division of Intramural Research, Eunice Kennedy Shriver National Institute of Child Health and Human Development, NIH, Bethesda, MD, USA., Iranzo J; NCBI, National Library of Medicine, Bethesda, MD, USA., Chon H; SFR, Division of Intramural Research, Eunice Kennedy Shriver National Institute of Child Health and Human Development, NIH, Bethesda, MD, USA., Grinberg A; Mouse Core, Division of Intramural Research, Eunice Kennedy Shriver National Institute of Child Health and Human Development, NIH, Bethesda, MD, USA., Crouch RJ; SFR, Division of Intramural Research, Eunice Kennedy Shriver National Institute of Child Health and Human Development, NIH, Bethesda, MD, USA. Electronic address: crouchr@mail.nih.gov.

Publikováno v: Cell reports [Cell Rep] 2018 Oct 30; Vol. 25 (5), pp. 1135-1145.e5.