Zobrazeno 1 - 7
of 7
pro vyhledávání: '"Hasim Zecic"'
Autor:
Judy M. Suh, Sandra Frauchiger, Michael Soth, Xiaochun Han, Ronald J. Hill, Buelent Kocer, Taygerly Joshua Paul Gergely, Jaehyeon Park, Hong Jun-Bae, Andreas Kuglstatter, Rama K. Kondru, Tobias Gabriel, Renee Litman, Yan Lou, Zachary Kevin Sweeney, Mcintosh Joel, Nolan James Dewdney, Dana Davis, David Michael Goldstein, Timothy D. Owens, Hasim Zecic, Keshab Sarma
Publikováno v:
Journal of Medicinal Chemistry. 58:512-516
Structure-based drug design was used to guide the optimization of a series of selective BTK inhibitors as potential treatments for Rheumatoid arthritis. Highlights include the introduction of a benzyl alcohol group and a fluorine substitution, each o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b2706725af4b785142b07ad80c3bfd24
https://doi.org/10.1021/jm500305p
https://doi.org/10.1021/jm500305p
Autor:
Mcintosh Joel, Andreas Kuglstatter, Paul Weller, Sarah C. Abbot, David C. Swinney, Brad Loe, Tobias Gabriel, Roland J. Billedeau, Martin Stahl, Hasim Zecic, Nidhi Arora, Eva Papp, Humberto Bartolome Arzeno, Brian Wong, Allassan Abubakari, Nolan James Dewdney, David Michael Goldstein, Man-Ling Sung, Rebecca T Suttman, Michael Soth, Jaehyeon Park, Kieran Durkin, Fujun Li, Manjiri Ghate, Kristen Lynn Mccaleb, Sandra Frauchiger, Ronald J. Hill
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 21:3452-3456
Learnings from previous Roche p38-selective inhibitors were applied to a new fragment hit, which was optimized to a potent, exquisitely selective preclinical lead with a good pharmacokinetic profile.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aa8eb5a3a44a865221a520c55232f9f7
https://doi.org/10.1016/j.bmcl.2011.03.098
https://doi.org/10.1016/j.bmcl.2011.03.098
Autor:
Jaehyeon Park, Harlan F Reese, Yun-Chou Tan, Hasim Zecic, Martin Stahl, Keshab Sarma, Renee Litman, Alejandra Trejo, William Bingenheimer, Michael Soth, David Michael Goldstein, Mary Welch, Eric Brian Sjogren, Man-Ling Sung, Sandra Frauchiger, Nolan James Dewdney, Bong San Pablo, Eva Papp, Daniel McWeeney, Ronald J. Hill, Paul Weller, Manjiri Ghate, JoAnn La Fargue, Brian Wong, Stacie A. Dalrymple, James Patrick Dunn, David Mark Rotstein, Richard T. Roberts, Bradford Graves, Rebecca T Suttman, Mcintosh Joel, Farrell Robert P, Andreas Kuglstatter, Chen Jian Jeffrey, Fujun Li, Humberto Bartolome Arzeno, Brad Loe, Tobias Gabriel
Publikováno v:
Journal of Medicinal Chemistry. 54:2255-2265
The development of a new series of p38α inhibitors resulted in the identification of two clinical candidates, one of which was advanced into a phase 2 clinical study for rheumatoid arthritis. The original lead, an lck inhibitor that also potently in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5bdfa3e0a0a96eaca0eea2feab67e249
https://doi.org/10.1021/jm101423y
https://doi.org/10.1021/jm101423y
Publikováno v:
Tetrahedron Letters. 51:6422-6425
A facile synthesis of a series of 1-alkoxyisoquinolines and (2H)-isoquinolones by an intramolecular 6-endo-dig cyclization of ortho-alkynylbenzonitriles in the presence of a catalytic amount of hydrido(dimethylphosphinous acid-κP)[hydrogen bis(dimet
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2f296a7705d04e6b88e551f2d6c191a0
https://doi.org/10.1016/j.tetlet.2010.09.136
https://doi.org/10.1016/j.tetlet.2010.09.136
Autor:
David M, Goldstein, Michael, Soth, Tobias, Gabriel, Nolan, Dewdney, Andreas, Kuglstatter, Humberto, Arzeno, Jeffrey, Chen, William, Bingenheimer, Stacie A, Dalrymple, James, Dunn, Robert, Farrell, Sandra, Frauchiger, JoAnn, La Fargue, Manjiri, Ghate, Bradford, Graves, Ronald J, Hill, Fujun, Li, Renee, Litman, Brad, Loe, Joel, McIntosh, Daniel, McWeeney, Eva, Papp, Jaehyeon, Park, Harlan F, Reese, Richard T, Roberts, David, Rotstein, Bong, San Pablo, Keshab, Sarma, Martin, Stahl, Man-Ling, Sung, Rebecca T, Suttman, Eric B, Sjogren, Yunchou, Tan, Alejandra, Trejo, Mary, Welch, Paul, Weller, Brian R, Wong, Hasim, Zecic
Publikováno v:
Journal of medicinal chemistry. 54(7)
The development of a new series of p38α inhibitors resulted in the identification of two clinical candidates, one of which was advanced into a phase 2 clinical study for rheumatoid arthritis. The original lead, an lck inhibitor that also potently in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::cda31600d6054cc75ed83ea768d5f392
https://pubmed.ncbi.nlm.nih.gov/21375264
https://pubmed.ncbi.nlm.nih.gov/21375264
Publikováno v:
ChemInform. 42
1-Alkoxyisoquinolines as major products can be easily converted into isoquinolines by dealkylation with HBr in acetic acid.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::54005b68923c1737b8a404824493a5be
https://doi.org/10.1002/chin.201112148
https://doi.org/10.1002/chin.201112148
Autor:
Teresa Alejandra Trejo-Martin, Roland J. Billedeau, Hasim Zecic, Nolan James Dewdney, Michael Soth, Tobias Gabriel, David Michael Goldstein, Kristen Lynn Mccaleb, Sarah C. Abbot
Publikováno v:
ChemInform. 41
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::678907f8a87bf8fade9ab79cb7f743de
https://doi.org/10.1002/chin.201013129
https://doi.org/10.1002/chin.201013129