Výsledky vyhledávání - "Hasib Salah-Uddin"

M344 promotes nonamyloidogenic amyloid precursor protein processing while normalizing Alzheimer’s disease genes and improving memory

Autor: Claude-Henry Volmar, Hasib Salah-Uddin, Karolina J. Janczura, Paul Halley, Guerline Lambert, Andrew Wodrich, Sivan Manoah, Nidhi H. Patel, Gregory C. Sartor, Neil Mehta, Nancy T. H. Miles, Sachi Desse, David Dorcius, Michael D. Cameron, Shaun P. Brothers, Claes Wahlestedt

Publikováno v: Proceedings of the National Academy of Sciences of the United States of America

Significance Hundreds of failed clinical trials with Alzheimer’s disease (AD) patients over the last fifteen years demonstrate that the one-target–one-disease approach is not effective in AD. In silico, structure-based, multitarget drug design ap

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3c50407444a518ddbd6df4f5ba402bdd
https://doi.org/10.1073/pnas.1707544114

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Autor: Narendra N. Tandon, Hasib Salah-Uddin, Isobel Ford, Asim K. Duttaroy, Mike Greaves, Margaret Jane Gordon

Publikováno v: Molecular and Cellular Biochemistry. 239:203-211

Increased platelet reactivity has been implicated in the vascular complications of myeloproliferative diseases and diabetes mellitus. The mechanisms of platelet hyperresponsiveness have not been fully explained. Expression of CD36 or fatty acid trans

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::b4a27ba8ceee288714f54f3df1bd827e
https://doi.org/10.1023/a:1020583630536

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Amygdala-Dependent Fear Is Regulated by Oprl1 in Mice and Humans with PTSD

Autor: Kerry J. Ressler, Yen Ting Chen, Thomas D. Bannister, Michael D. Cameron, Bekh Bradley, Lynn M. Almli, Claes Wahlestedt, Elisabeth B. Binder, Rauel Andero, Jennifer S. Stevens, Hasib Salah-Uddin, Tanja Jovanovic

Publikováno v: Science Translational Medicine. 5

The amygdala-dependent molecular mechanisms driving the onset and persistence of posttraumatic stress disorder (PTSD) are poorly understood. Recent observational studies have suggested that opioid analgesia in the aftermath of trauma may decrease the

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e62be07c0fc6ef8a224c196d4c475b84
https://doi.org/10.1126/scitranslmed.3005656

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Regulation of neuronal plasticity and fear by a dynamic change in PAR1-G protein coupling in the amygdala

Autor: R. A. John Challiss, Anna E. Skrzypiec, Rahul S. Shah, Mariusz Mucha, Ian D. Forsythe, Emanuele Schiavon, Julie-Myrtille Bourgognon, Robert Pawlak, Satyam Patel, Hasib Salah-Uddin, Benjamin K. Attwood

Publikováno v: Molecular psychiatry

Fear memories are acquired through neuronal plasticity, an orchestrated sequence of events regulated at circuit and cellular levels. The conventional model of fear acquisition assumes unimodal (for example, excitatory or inhibitory) roles of modulato

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::70475135a5f6166b1e655d79ecc3d4f4
https://pubmed.ncbi.nlm.nih.gov/23032873

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Altered M(1) muscarinic acetylcholine receptor (CHRM1)-Galpha(q/11) coupling in a schizophrenia endophenotype

Autor: R. A. John Challiss, Geoffrey Pavey, Jim J. Hagan, Jeannette M. Watson, Kriss Harris, Elizabeth Scarr, Brian Dean, Hasib Salah-Uddin

Publikováno v: Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. 34(9)

Alterations in muscarinic acetylcholine receptor (CHRM) populations have been implicated in the pathology of schizophrenia. Here we have assessed whether the receptor function of the M(1) subtype (CHRM1) is altered in a sub-population of patients wit

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7ca6b9500301d926f686f7d4e64cda2a
https://pubmed.ncbi.nlm.nih.gov/19404243

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Pharmacological assessment of m1 muscarinic acetylcholine receptor-gq/11 protein coupling in membranes prepared from postmortem human brain tissue

Autor: David R. Thomas, Jim J. Hagan, Jeannette M. Watson, Hasib Salah-Uddin, R. A. John Challiss, Ceri H. Davies, Martyn D. Wood

Publikováno v: The Journal of pharmacology and experimental therapeutics. 325(3)

Using a selective Galpha(q/11) protein antibody capture guanosine 5'-O-(3-[35S]thio)triphosphate ([35S]GTPgammaS) binding approach, it has been possible to perform a quantitative pharmacological examination of the functional activity of the M(1) musc

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fa95d512a265c5464739fc46870c05fb
https://pubmed.ncbi.nlm.nih.gov/18322150

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Surface expression of fatty acid translocase (FAT/CD36) on platelets in myeloproliferative disorders and non-insulin dependent diabetes mellitus: effect on arachidonic acid uptake

Autor: Hasib, Salah-Uddin, Margaret J, Gordon, Isobel, Ford, Narendra N, Tandon, Mike, Greaves, Asim K, Duttaroy

Publikováno v: Molecular and cellular biochemistry. 239(1-2)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::4de757b0025a007807df57fb6ab8b46a
https://pubmed.ncbi.nlm.nih.gov/12479587

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