The Effect of KATP Channel Blocker Glibenclamide on CGRP-Induced Headache and Hemodynamic in Healthy Volunteers

Autor: Hande Coskun, Fatima Azzahra Elbahi, Mohammad Al-Mahdi Al-Karagholi, Hashmat Ghanizada, Majid Sheykhzade, Messoud Ashina

Publikováno v: Frontiers in Physiology, Vol 12 (2021)

BackgroundCalcitonin gene-related peptide (CGRP) dilates cranial arteries and triggers headache. The CGRP signaling pathway is partly dependent on activation of ATP-sensitive potassium (KATP) channels. Here, we investigated the effect of the KATP cha

Externí odkaz: https://doaj.org/article/ad476ca140d44eaf8cc8efa7acf4ac92

Prolactin in headache and migraine: A systematic review of preclinical studies

Autor: Mohammad Al‐Mahdi Al‐Karagholi, Veberka Kalatharan, Hashmat Ghanizada, Gregory Dussor, Messoud Ashina

Publikováno v: Headache: The Journal of Head and Face Pain. 63:577-584

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::9cf3c653e5bb0f728a16e74ff6bb85ae
https://doi.org/10.1111/head.14412

Early treatment with sumatriptan prevents PACAP38-induced migraine: A randomised clinical trial

Autor: Ditte Georgina Zhang, Hashmat Ghanizada, Nita Katarina Frifelt Wienholtz, Jacob P. Thyssen, Messoud Ashina, Alexander Egeberg, Casper Emil Christensen, Hande Coskun, Jens Hannibal, Mohammad Al-Mahdi Al-Karagholi

Publikováno v: Cephalalgia. 41:731-748

Objective To determine whether early treatment with sumatriptan can prevent PACAP38-induced migraine attacks. Methods A total of 37 patients with migraine without aura were enrolled between July 2018 to December 2019. All patients received an intrave

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4cc6ef8bb210b7309e4e28de8e808567
https://doi.org/10.1177/0333102420975395

Human Cerebral Perfusion, Oxygen Consumption, and Lactate Production in Response to Hypoxic Exposure

Autor: Ulrich Lindberg, Henrik Larsson, Albert Gjedde, Messoud Ashina, Nanna Arngrim, Mark B Vestergaard, Hashmat Ghanizada, Olaf B. Paulson

Publikováno v: Vestergaard, M B, Ghanizada, H, Lindberg, U, Arngrim, N, Paulson, O B, Gjedde, A, Ashina, M & Larsson, H B W 2022, ' Human Cerebral Perfusion, Oxygen Consumption, and Lactate Production in Response to Hypoxic Exposure ', Cerebral cortex (New York, N.Y. : 1991), vol. 32, no. 6, pp. 1295-1306 . https://doi.org/10.1093/cercor/bhab294
Vestergaard, M B, Ghanizada, H, Lindberg, U, Arngrim, N, Paulson, O B, Gjedde, A, Ashina, M & Larsson, H B W 2022, ' Human Cerebral Perfusion, Oxygen Consumption, and Lactate Production in Response to Hypoxic Exposure ', Cerebral Cortex, vol. 32, no. 6, pp. 1295–1306 . https://doi.org/10.1093/cercor/bhab294

Exposure to moderate hypoxia in humans leads to cerebral lactate production, which occurs even when the cerebral metabolic rate of oxygen (CMRO2) is unaffected. We searched for the mechanism of this lactate production by testing the hypothesis of upr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::580e7a6f701bfea98cd5217d65fa2d77
https://pure.au.dk/portal/da/publications/human-cerebral-perfusion-oxygen-consumption-and-lactate-production-in-response-to-hypoxic-exposure(a8569125-4a6c-4336-aec6-ceb0f7989ede).html

Cerebrovascular effects of glibenclamide investigated using high-resolution magnetic resonance imaging in healthy volunteers

Autor: Mohammad Al-Mahdi Al-Karagholi, Hashmat Ghanizada, Cherie Amalie Waldorff Nielsen, Assan Ansari, Christian Gram, Samaria Younis, Mark B Vestergaard, Henrik BW Larsson, Lene Theil Skovgaard, Faisal Mohammad Amin, Messoud Ashina

Publikováno v: J Cereb Blood Flow Metab

Glibenclamide inhibits sulfonylurea receptor (SUR), which regulates several ion channels including SUR1-transient receptor potential melastatin 4 (SUR1-TRPM4) channel and ATP-sensitive potassium (KATP) channel. Stroke upregulates SURl-TRPM4 channel,

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2d3a600fe4a85791d1aa78038b312c95
https://doi.org/10.1177/0271678x20959294