Zobrazeno 1 - 10
of 28
pro vyhledávání: '"Hashim Nizar"'
Publikováno v:
Organic Process Research & Development. 18:665-667
An improved process for the preparation of 5-(1-piperazinyl)benzofuran-2-carboxamide, a key intermediate used in the synthesis of antidepressant drug vilazodone is reported.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1a8589eaade6cd281a2db855aa3a36dc
https://doi.org/10.1021/op500070t
https://doi.org/10.1021/op500070t
Publikováno v:
Organic Process Research & Development. 18:662-664
A process impurity, ethoxycarbonylcefprozil (9), formed in the synthesis of cefprozil (1) was controlled with addition of a catalytic amount of methanesulfonic acid.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ac578e1191a4bde46fd81f2ee7425fd1
https://doi.org/10.1021/op5000545
https://doi.org/10.1021/op5000545
Publikováno v:
Synthetic Communications. 36:211-214
An efficient new method for the silylation of p‐nitrobenzyl‐2‐diazoacetoacetate using hexamethyl disilane and iodine is presented.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d3c277e255eb453073f2cf1de5dc5c65
https://doi.org/10.1080/00397910500334520
https://doi.org/10.1080/00397910500334520
Publikováno v:
Tetrahedron Letters. 54:929-931
A simple and convenient method for the N-formylation of primary and secondary amines including amino acids has been developed utilizing formamide and sodium methoxide in moderate to excellent yield. This reagent is also utilized for one pot conversio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::264d4a72c4b7ab2c88ff16310fa0e74f
https://doi.org/10.1016/j.tetlet.2012.12.009
https://doi.org/10.1016/j.tetlet.2012.12.009
Publikováno v:
Organic Process Research & Development. 7:758-761
A process for the synthesis of carbacephem key intermediate (4-nitrophenyl)methyl,7-amino-1-carba(dethia)-3-chloro-3-cephem-4-carboxylate, monohydrochloride (1) via chlorination and deacylation employing chlorotriphenoxyphosphonium chloride [(PhO)3P+
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::823dcc10c7265292357a5d8dabd59b44
https://doi.org/10.1021/op034026x
https://doi.org/10.1021/op034026x
Publikováno v:
Organic Process Research & Development. 16:1566-1568
A novel synthetic route for commercial preparation of cinacalcet hydrochloride (1), a calcimimetic agent and calcium-sensing receptor antagonist, is described. Our synthetic approach involves the preparation of cinacalcet using C–C bond formation c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f5ecf4436624868bdb33db9f6acbcb84
https://doi.org/10.1021/op300164y
https://doi.org/10.1021/op300164y
Autor:
Hashim Nizar, Bishwa Prakash Rai, Shailendra Kumar Singh, Neera Tewari, Vinod George, Mohan Prasad
Publikováno v:
Organic Process Research & Development. 11:773-775
An efficient synthesis of a 1β-methyl carbapenem antibiotic, meropenem, is described. The present process does not involve cryogenic temperatures, chromatographic purification, or reverse osmosis and is amenable to large scale synthesis.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5bf422829328dc1adf44511294b3ec32
https://doi.org/10.1021/op700088y
https://doi.org/10.1021/op700088y
Publikováno v:
Organic Process Research & Development. 9:827-829
An optimized process for the stereoselective synthesis of 1-β-methyl carbapenem key intermediate (3S,4S)-[(R)-1‘-((tert-butyldimethylsilyl)oxy)ethyl]-4-[(R)-1-carboxyethyl]-2-azetidinone (1) and (3R,4R)-4-acetoxy-3-[(R)-1‘-((tert-butyldimethylsi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a827443e6100fecc030c7f3a9713637d
https://doi.org/10.1021/op0501085
https://doi.org/10.1021/op0501085
Publikováno v:
ChemInform. 44
Inexpensive formamide and sodium methoxide are employed for the N-formylation of amines and amino acids.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9a2a37c9eb926772d2c9accb66ba030d
https://doi.org/10.1002/chin.201322039
https://doi.org/10.1002/chin.201322039
Publikováno v:
Organic Process Research & Development. 7:933-935
An optimized process for the stereospecific synthesis of carbacephem key intermediates 3β-[4-(S)-phenoxyacetylamino-4β-[2-(2-furyl)ethyl]azetidin-2-one (1) and 3β-[4-(S)-phenyl-acetylamino-4β-[2(2-furyl)ethyl)]azetidin-2-one] (2) is described. Th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::bbc2e63fe3fccd0c75717828ed870543
https://doi.org/10.1021/op034074h
https://doi.org/10.1021/op034074h